1,355,362 research outputs found
Akula Dream (The Mindset Suite)
No full textAn old Russian Akula submarine gets a new captain. But Captain Pavel seems to care very little about the navy or war. Indeed, he prefers to lead group discussions about spiritual matters and dresses in a cassock; his favourite pastime is shamanic drumming. The more traditional sailors begin to have doubts. The Captain believes the Earth is calling us and that we need to answer.
Formally, the work is unusual in that it successfully blends a narrative drama with an experimental video approach. The artist was featured in a 6 page interview in Art Monthly Issue 390 in 2015 where the mixture of genres was discussed.
The research question in ‘Akula Dream’ is; Can video art also contain a narrative plot? The distinctions between artist’s film and artist’s video have all softened in recent years. Barber’s research is to propose and test a kind of hybrid, multi-form that recognises the de-historicising that has taken place and thus there is a new space to be researched. The film uses well-established actors and was shot on a real Soviet submarine. In common with the other works in Barber’s Mindset Suite, e.g. ‘Dude Down’ or ‘The Freestone Drone’, ‘Akula Dream’ references the ubiquity of military thinking and the state of constant war that we find ourselves in. Additionally, interweaves ecological concerns but re-stages them within a submarine thriller genre. The works are in the tradition of Godardian essay films but again audiences view moving image differently and are not so invested in categories or traditions. Lastly, Barber’s unusual writing style, and plot about a Russian sub Captain getting into shamanic drumming, again both reconfigure genres and make a case for a ‘third space’ that has elements of mainstream production but is also clearly video art.
As research, ‘Akula Dream has been successful; the traditional film crowd like it as it is genre-pushing by their standards, and the art crowd like it because it has pace and a plot, something of a respite in their world. It received a standing ovation at Oberhausen, Germany’s oldest film festival
Cell therapy for hemophilia A
No full textHemophilia A (HA) is a X-bleeding disorder caused by mutations in the FVIII gene, leading to deficient coagulation factor VIII activity. Current treatment entails repeated infusions of exogenous FVIII, which is frequently hampered by the formation of neutralising antibodies. This study investigates the efficacy of fetal liver (FL) and juvenile bone marrow (JBM) cells for HA cell therapy, with an emphasis on engraftment and FVIII production in neonatal and adult HA mice. We show that FL cells, particularly those from embryonic day (E) 13, can engraft and produce FVIII in HA newborn mice even without preconditioning, greatly improving the bleeding phenotype. Adult bone marrow (ABM) cells, on the other hand, require busulfan (BU) preconditioning in order to engraft and correct phenotypes in neonatal HA mice. Furthermore, we study the transplantation kinetics of JBM cells, finding that they outperform ABM cells in terms of engraftment, particularly in adult HA mice preconditioned with BU. Notably, the use of granulocyte colony-stimulating factor (G-CSF) as a mobilisation agent improves JBM cell engraftment, suggesting a feasible technique for reducing reliance on hazardous preconditioning regimens. These findings indicate FL and JBM cells as feasible sources for HSC transplantation in HA treatment, providing insights into their varying engraftment efficiencies and the function of mobilisation agents in improving transplantation outcomes. This study paves the way for new HA treatment techniques, highlighting the importance of cell source selection and mobilisation tactics in obtaining effective and long-term therapeutic effects
Essays on Life, Science and Society [electronic resource] : The World through the Eyes of a Life Scientist /
No full textThis collection of nine essays provides an entertaining and thoughtful glimpse into trending topics in our lives. The author, Dr. Akula, tackles questions on life, science, and society from a biologist’s perspective. The book covers a broad range of topics, including common questions with complex answers intermixed with some religion and humor, making it a great read to give your brain cells a boost. The field of Science is massive - in fact, it’s the size of the universe, which means picking just a few topics to discuss is no mean feat. This book is a start, but there is more to come as Dr. Akula explores various subjects to discuss and shed new light on. This collection of essays will appeal to scientists, and to lay readers with an interest in the natural sciences. Its goal is to ensure that science isn’t accessible to only a few people, but is instead disseminated to many. After all, a Smart World is the key to a Better Tomorrow and a Brighter Future.Chapter 1. Understanding Order in the disorder -- Chapter 2. Einstein’s theory of relativity borrowed from the spice rack of Hinduism? -- Chapter 3. Flu or a bug? -- Chapter 4. Why I chose evolution over religion! -- Chapter 5. It is mi(y) RNA! -- Chapter 6. A morons footnote to controlling human brain -- Chapter 7. An insiders’ view! -- Chapter 8. Down the Line -- Chapter 9: What is intelligence?This collection of nine essays provides an entertaining and thoughtful glimpse into trending topics in our lives. The author, Dr. Akula, tackles questions on life, science, and society from a biologist’s perspective. The book covers a broad range of topics, including common questions with complex answers intermixed with some religion and humor, making it a great read to give your brain cells a boost. The field of Science is massive - in fact, it’s the size of the universe, which means picking just a few topics to discuss is no mean feat. This book is a start, but there is more to come as Dr. Akula explores various subjects to discuss and shed new light on. This collection of essays will appeal to scientists, and to lay readers with an interest in the natural sciences. Its goal is to ensure that science isn’t accessible to only a few people, but is instead disseminated to many. After all, a Smart World is the key to a Better Tomorrow and a Brighter Future
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
NOC Arctic Carbon Research Expedition Report No 87. 2025 MY Akula: Greenland fjords. 15th to 29th August 2025.
No full textThe purpose of the Greenland research cruise on board MY Akula was to investigate the interactions between DOC concentration and composition and the phytoplankton and bacterioplankton communities in Greenland fjords and coastal seas. The MY Akula cruise departed from Kulusuk-Tasilaq on the 15th August 2025 and arrived at Qaqortoq on 27th August 2025 when the science finished. Onboard there were two research scientists from the National Oceanography Centre, two members of Augmentum, and 14 crew members.
The cruise consisted of the sampling of one fjord on the East coast of Greenland (Sermilik fjord) and two fjords on the Southwest coast of Greenland (Iterdlak and Tunulluarfjik fjords). Each station comprised a series of observations of water column properties (temperature, salinity, photosynthetic active radiation, fluorescence and coloured organic matter), nutrients, dissolved organic carbon and its fluorescence, chlorophyll biomass as an indicator of phytoplankton abundance, phytoplankton imaging and eDNA samples for eukaryote and prokaryote plankton composition
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
No full textThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
Do the retinal abnormalities in X-linked juvenile retinoschisis include impaired phototransduction?
No full text: X-linked juvenile retinoschisis (XLRS), a hereditary retinal disorder primarily affecting males, is characterized by the formation of cystic spaces between the outer plexiform layer and outer nuclear layer of the retina. Mutations in the RS1 gene, which encodes the extracellular binding protein retinoschisin, are responsible for XLRS pathogenesis. While the role of retinoschisin in maintaining retinal integrity is well established, there is growing evidence suggesting compromised photoreceptor function in XLRS. To investigate the molecular pathways affected by RS1 deficiency, particularly in phototransduction, we performed electroretinographic (ERG) and proteomic analyses on retinae from Rs1 knockout mice, a model of human XLRS. The Rs1 knockout mice had reduced ERG a-wave amplitudes. Correspondingly, differential expression analysis revealed downregulation of proteins crucial for phototransduction, with Ingenuity Pathway Analysis (IPA) highlighting "phototransduction" as the most significantly downregulated biological theme. Compensatory mechanisms were also observed in the IPA, including upregulation of synaptic remodeling, inflammation, cell adhesion, and G-protein signaling. These findings strongly implicate an underrecognized role of photoreceptor dysfunction in XLRS pathology. We speculate that entrapment of mutant retinoschisin protein within photoreceptor inner segments as well as disrupted reciprocal regulation between L-type voltage-gated calcium channels and retinoschisin contribute to the dysfunction in photoreceptors
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