106,914 research outputs found
Genotoxicity of food preservative sodium sorbate in human lymphocytes in vitro
No full textThe genotoxic effects of antimicrobial food additive sodium sorbate (SS) was assessed by using chromosome aberrations (CAs), sister-chromatid exchanges (SCEs), and micronucleus (MN) in cultured human lymphocytes and comet assay in isolated human lymphocytes. Lymphocytes were treated with four concentrations (100, 200, 400 and 800 mu g/ml) of SS as well as a negative (sterile distilled water) and a positive control (Mitomycin-C: MMC for cultured lymphocytes and H2O2 for isolated lymphocytes). The result of this study indicated that SS increased the frequency of CAs at both 24 and 48 h period compared to control. When gaps were included, this increase was significant at 200, 400 and 800 mu g/ml concentrations at 24 h and, at all concentrations at 48 h treatment time. When gaps were excluded, this increase was significant at only 800 mu g/ml concentration at both 24 and 48 h treatments. In addition, SS increased SCEs/cell and MN frequency at 400 and 800 mu g/ml concentrations at both 24 and 48 h compared to negative control. Furthermore, this additive caused DNA damage at all concentrations in isolated human lymphocytes after 1 h in vitro exposure. The present results show that SS is genotoxic to the human peripheral blood lymphocytes in vitro at the highest concentrations
Köprü heißt Brücke. Warum die Türkei Europa braucht und Europa die Türkei
No full textSchmuhl H-W. Köprü heißt Brücke. Warum die Türkei Europa braucht und Europa die Türkei. In: Aksoy M, ed. Die türkisch-deutschen Beziehungen. Eine unendliche Geschichte. Frankfurt; 2010: 141-144
Story of Benzene and Leukemia: Epidemiologic Approach of Muzaffer Aksoy
No full textIn 1974, Professor Muzaffer Aksoy established a link to leukemia in humans as a result of occupational exposure to benzene. The aim of this study is to evaluate his epidemiological approach for his investigation on the effects of benzene and to bring attention to the benzene problem in Turkey. Dr. Aksoy observed that a large group of leukemic patients were shoemakers, or they worked in leather manufacturing. In the 1960s, benzene was a popular solvent in the leather industry. Dr. Aksoy conducted a field investigation in Gedikpasa-Istanbul, where the shoemakers worked so that he could draw his key observations from actual environmental conditions. With a gas detector, he found the concentration of benzene in these work places to be 150-210 ppm and up to 650 ppm on rare occasions. He performed an epidemiological study and health education among 28,500 shoe, slipper and handbag workers during the period from 1967 to 1974. He published these data, establishing an association between benzene and leukemia. The incidence of leukemia among the shoe workers was decreased by screening, health education, and legislative actions in Turkey, but it began to increase again because of lack of an occupational health policy and underestimation of the problem. These results suggest the importance of primary prevention of occupational cancers. Dr. Aksoy's epidemiologic approach may highlight the necessity for detailed investigations of the occupational status of patients who need medical aid in order to diagnose the real underlying factor
Clastogenic effects of food additive citric acid in human peripheral lymphocytes
No full textClastogenic properties of the food additive citric acid, commonly used as an antioxidant, were analysed in human peripheral blood lymphocytes. Citric acid induced a significant increase of chromosomal aberrations (CAs) at all the concentrations and treatment periods tested. Citric acid significantly decreased mitotic index (MI) at 100 and 200 mu g ml(-1) concentrations at 24 h, and in all concentrations at 48 h. However, it did not decrease the replication index (RI) significantly. Citric acid also significantly increased sister chromatid exchanges (SCEs) at 100 and 200 mu g ml(-1) concentrations at 24 h, and in all concentrations at 48 h. This chemical significantly increased the micronuclei frequency (MN) compared to the negative control. It also decreased the cytokinesis-block proliferation index (CBPI), but this result was not statistically significant
Genotoxicity assessment of vaccine adjuvant squalene
No full textThe genotoxic potential of the vaccine adjuvant Squalene was assessed by the chromosomal aberrations (CAs), sister chromatid exchanges (SCEs) and micronucleus (MNs) tests in human lymphocytes and comet assay in both human and rat lymphocytes. Five different concentrations of squalene (1250-20,000 mu g/ml for human lymphocytes and 0.07-1.12 mg/kg for rat lymphocytes) were studied. Squalene did not affect the CAs and MN frequency, in all treatments in vitro. A significant increase in SCEs was observed in almost all concentrations at 24 h treatment. Squalene did not affect significantly the comet tail length (CTL) (except 2500 mu g/ml) and comet tail intensity (CTI) at all treatments in vitro. In rats, squalene significantly increased and decreased CTL and CTI in some doses. Although there are increasing and reduction in the effect, squalene cannot be regarded as genotoxic in human lymphocytes. However, further in vivo studies are required to be sure on the effect. (C) 2013 Elsevier Ltd. All rights reserved
Centaurea yaltirikii subsp dumanii subsp nov (C. sect. Pseudoseridia, Asteraceae) in Marmara region of Turkey
No full textA new subspecies of Centaurea yaltirikii N. Aksoy, H. Duman and A. Efe subsp. dumanii N. Aksoy and A. Efe (C. sect. Pseudoseridia Wagenitz, Asteraceae), is described and illustrated with diagnostic characters and taxonomic comments. The characteristics of the new subspecies are compared with those of the type subspecies from which it differs mainly in the hair of the leaves, stomata types, length and width of the pappus and surface of achene. In addition, the geographic distribution of the new subspecies is mapped
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Genotoxic Effects of Electromagnetic Fields from High Voltage Power Lines on Some Plants
No full textAllium cepa bulbs were germinated in pots for three days on treatment area on which 380 kV high voltage power lines are passing. Ten bulbs were set up for each treatment area (0 m (meter), 10 m, 25 m, 50 m and 100+ m for control from power lines). Triticum baeoticum Boiss. subsp. baeoticum seeds were collected at same distance from power lines on planted field. Ten seeds from each area were germinated in Petri dishes for three days in laboratory. The treatment groups were compared with the control group for mitotic index and chromosome aberrations. Data obtained showed that electromagnetic fields from high voltage power lines increased the mitotic index and chromosome aberrations
Preface: HS01 – Changes in Flood Risk and Perception in Catchments and Cities
No full textNo abstract available
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