136 research outputs found
Supplemental material for Prognostic factors for survival in patients with metastatic malign melanoma treated with ipilimumab: Turkish Oncology Group study
No full textSupplemental material for Prognostic factors for survival in patients with metastatic malign melanoma treated with ipilimumab: Turkish Oncology Group study by Yuksel Urun, H Arzu Yasar, Hande Turna, Ece Esin, A Murat Sedef, Ali Alkan, Berna Oksuzoglu, Nuriye Ozdemir, MA Nahit Sendur, Ahmet Sezer, Saadettin Kılıckap, Gungor Utkan, Tulay Akman, Hakan Akbulut, Ismail Celik and Huseyin Abalı in Journal of Oncology Pharmacy Practice</p
The preventive effect of oxytocin to cisplatin-induced neurotoxicity: An experimental rat model
No full textPeripheral neurotoxicity is a frequent dose-limiting side effect of the chemotherapeutic agent cisplatin. This study was conducted to investigate the preventive effect of oxytocin (OT) on cisplatin-induced neurotoxicity in rats. Forty-four adult female rats were included in the study. Thirty-six rats were administered intraperitoneally (i.p.) single dose cisplatin 10 mg/kg and divided in to 3 groups. The first group (n=12) received saline i.p., whereas the second group (n=12) and the third group (n=12) were injected with 80 µg/kg and 160 µg/kg OT, respectively, for 10 days. The remaining 8 rats served as the control group. Electromyography (EMG) studies were recorded and blood samples were collected for the measurement of plasma lipid peroxidation (malondialdehyde; MDA), tumor necrosis factor (TNF)-?, and glutathione (GSH) levels. EMG findings revealed that compound muscle action potential amplitude was significantly decreased and distal latency was prolonged in the nontreated cisplatin-injected rats compared with the control group (P<0.005). Also, nontreated cisplatin-injected rats showed significantly higher TNF-? and MDA levels and lower GSH level than control group. The administration of OT significantly ameliorated the EMG alterations, suppressed oxidative stress and inflammatory parameters, and increased antioxidative capacity. We suggest that oxytocin may have beneficial effects against cisplatin-induced neurotoxicity. © 2015 Tulay Akman et al
metastatik kolorektal kanserli hastalarda kras mutasyon durumunun klinikopatolojik özellikler, sağkalım süreleri ve tedavi yanıtları ile ilişkisinin retrospektif olarak değerlendirilmesi
No full textImpact of Accompanying Comorbidities on Survival in Patients with Stage IIIB- IV Non-Small-Cell Lung Cancer
No full textDouble skew cyclic codes over Fq + vFq
No full textIn order to get a better code rate, this study focuses on the construction of double skew cyclic codes over the ring R = F-q + v(q) with v(2) = v , where q is a prime power. We investigate the generator polynomials, minimal spanning sets, generator matrices, and the dual codes over the ring R . As an implementation, the obtained results are illustrated with some suitable examples. Here, we introduce a construction for new generator matrices and thus achieve codes with improved parameters compared to those available in the existing literature. Finally, we tabulate our obtained codes over the ring R .Council of Scientific & Industrial Research (CSIR), Govt. of India [09/1023(0027)/2019-EMR-1]; Scientific and Technological Research Council of Turkey (TUBITAK) ARDEB 1002-A [123F286]In this research, the author Ashutosh Singh is thankful to the Council of Scientific & Industrial Research (CSIR), Govt. of India under File No. 09/1023(0027)/2019-EMR-1 and the author Tulay Yildirim is thankful to the Scientific and Technological Research Council of Turkey (TUBITAK) ARDEB 1002-A Grant No 123F286 for the financial support
Prevention of Pazopanib-Induced Prolonged Cardiac Repolarization and Proarrhythmic Effects
No full textBackground: Pazopanib (PZP) may induce prolonged cardiac repolarization and proarrhythmic effects, similarly to other tyrosine kinase inhibitors. Objectives: To demonstrate PZP-induced prolonged cardiac repolarization and proarrhythmic electrophysiological effects and to investigate possible preventive effects of metoprolol and diltiazem on ECG changes (prolonged QT) in an experimental rat model. Methods: Twenty-four Sprague-Dawley adult male rats were randomly assigned to 4 groups (n = 6). The first group (normal group) received 4 mL of tap water and the other groups received 100 mg/kg of PZP (Votrient® tablet) perorally, via orogastric tubes. After 3 hours, the following solutions were intraperitoneally administered to the animals: physiological saline solution (SP), to the normal group and to the second group (control-PZP+SP group); 1 mg/kg metoprolol (Beloc, Ampule, AstraZeneca), to the third group (PZP+metoprolol group); and 1mg/kg diltiazem (Diltiazem, Mustafa Nevzat), to the fourth group (PZP+diltiazem group). One hour after, and under anesthesia, QTc was calculated by recording ECG on lead I. Results: The mean QTc interval values were as follows: normal group, 99.93 ± 3.62 ms; control-PZP+SP group, 131.23 ± 12.21 ms; PZP+metoprolol group, 89.36 ± 3.61 ms; and PZP+diltiazem group, 88.86 ± 4.04 ms. Both PZP+metoprolol and PZP+diltiazem groups had significantly shorter QTc intervals compared to the control-PZP+SP group (p < 0.001). Conclusion: Both metoprolol and diltiazem prevented PZP-induced QT interval prolongation. These drugs may provide a promising prophylactic strategy for the prolonged QTc interval associated with tyrosine kinase inhibitor use
RISK FACTORS FOR EARLY WEANING AMONG BABIES FOLLOWED-UP IN A BABY-FRIENDLY PRIMARY CARE UNIT IN ISTANBUL
No full textObjective: This study aims to explore the breast-feeding profiles and the factors that affect breast-feeding and weaning attitudes among mothers of 0-12 month old babies in a baby-friendly primary care unit. Material and Method: The study was conducted in a Mother and Child Health Centre in Istanbul in May-October 2006. All 364 mothers who were registered in the health centre were enrolled. A total of 358 mothers were included in the study. Results: The frequencies of breastfeeding initiation and of breastfeeding within the first hour were 98.9% and 62.3% respectively. Among the babies older than 6 months (n=200), 52.5% were weaned before 6 months. Pacifier use (OR: 3.01, 95% CI: 1.35-6.69), being preterm (OR: 3.36, 95% CI: 1.04-10.79), having a job (OR: 2.83, 95% CI: 1.14-7.04) or smoking (OR: 2.27, 95% CI: 1.01-5.14) were found to be risk factors for early weaning. Conclusion: Although the frequency of initiating breastfeeding is very high, the continuation duration is below the World Health Organization (WHO)'s recommendations. Physicians and other health workers should strongly recommend against smoking during prenatal and postnatal visits. Physicians should not support pacifiers, until we have sufficient data to support its benefits. In order to increase the duration of breast feeding, health professionals should focus on preterm babies, smoking or working mothers
Perspectives and practical applications of medical oncologists on defensive medicine (SYSIPHUS study): a study of the Palliative Care Working Committee of the Turkish Oncology Group (TOG)
No full textDefensive medicine occasionally indulges unnecessary treatment requests to defend against lawsuits for medical errors and the use of unapproved medical applications. This study determines the attitudes and orientations of medical oncologists on defensive medicine. A cross-sectional survey was sent by e-mail to medical oncologists. The survey was designed to determine the participants' demographic characteristics and defensive medicine practices. The survey measured the attitudes about defensive medicine practices of the oncologists based on a five-point Likert scale (never, rarely, sometimes, often, and always). One hundred and forty-six of a total of 402 physicians serving in oncology were fully filled, and the rate of return invitation was 36 %. The majority of participants were male, with a duration of between 7 and 9 years of work as university hospital officials, and the mean age was 46 +/- 9 (years). International guidelines were followed in the most common is NCCN, and the majority of respondents felt that the application of these guidelines improves their defensive medicine. All participants of defensive medicine who stand on the basis of the definition were found to be more afraid of complaints by patients' relatives. Physicians of 45 % was noted that applying defensive medicine. Among the participants were the most frequent checkups of positive defensive approach is defined as increasing or shortening the follow-up period, while avoiding high-risk patients were detected as described in the definition of negative defensive medicine. Both professional groups in both the positive and negative defensive medicine approach defensive medicine approach, academic tasks, work experience and job time, there was a significant correlation between the location. Made in single-and multivariable analyses, positions were identified both positive and negative defensive medicine is an independent risk factor for direction. Improving the working conditions of young physicians to protect against medical error may require additional educational opportunities
Erythrocyte Deformability and Oxidative Stress in Inflammatory Bowel Disease
No full textOxidative stress and reduced microvascular flow are important factors in the pathogenesis of inflammatory bowel disease (IBD). The increased oxidative stress reduces the eriytrocyte deformability. However, in IBD, there are no studies in the literature which evaluate erythrocyte deformability
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