1,721,057 research outputs found
Mastocytosis: Overview of Diagnosis and Classification
No full textMastocytosis is defined as a heterogeneous group of disorders characterized by clonal expansion and aberrant activation of mast cells. Most cases are associated with gain-of-function mutations in KIT, the receptor for stem cell factor, the major cytokine involved in mast cell growth and differentiation. While a rare disease, it is increasingly diagnosed due to the refinements in diagnostic criteria and increased physician and patient awareness. Novel therapeutic approaches targeting mast cell survival and activation makes it important to correctly diagnosing the disease. This chapter serves as an introduction on the symptomatology, diagnostic criteria, classification, and treatment of mastocytosis, which are discussed in more detail in other chapters of the book.Mastocytosis is defined as a heterogeneous group of disorders characterized by clonal expansion and aberrant activation of mast cells. Most cases are associated with gain-of-function mutations in KIT, the receptor for stem cell factor, the major cytokine involved in mast cell growth and differentiation. While a rare disease, it is increasingly diagnosed due to the refinements in diagnostic criteria and increased physician and patient awareness. Novel therapeutic approaches targeting mast cell survival and activation makes it important to correctly diagnosing the disease. This chapter serves as an introduction on the symptomatology, diagnostic criteria, classification, and treatment of mastocytosis, which are discussed in more detail in other chapters of the book
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Skin Disease in Mastocytosis
No full textThe hallmark of mastocytosis is the pathological accumulation of mast cells in various tissues. The skin is the most frequently affected organ, followed by bone marrow. Cutaneous mast cell infiltration is usually associated with typical skin lesions. According to the morphology of the lesions, three subforms are distinguished, namely maculopapular cutaneous mastocytosis, diffuse cutaneous mastocytosis and cutaneous mastocytoma. Maculopapular cutaneous mastocytosis is further subdivided into a monomorphic and a polymorphic variant. An important diagnostic feature of all subforms is a positive Darier’s sign. There are significant clinical differences in skin lesions based on the age of disease onset. Paediatric patients often show cutaneous mastocytoma or the polymorphic variant of maculopapular cutaneous mastocytosis, normally without systemic involvement, and a transient disease course with spontaneous remission after several years. By contrast, adults typically present with the monomorphic variant of maculopapular cutaneous mastocytosis, usually associated with systemic mastocytosis and a chronic or progressive course. Patients with skin lesions, regardless of whether bone marrow and other organs are involved, can experience mast cell mediator symptoms such as pruritus, anaphylaxis, flushing and diarrhoea. The current treatment mainly aims at reducing mediator symptoms using antihistamines and, if indicated, also adrenaline, corticosteroids, sodium cromoglycate, specific immunotherapy and omalizumab. Preliminary study results indicate that specific tyrosine kinase inhibitors will soon also become relevant in the treatment of skin involvement in mastocytosis
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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