4,263 research outputs found
Evidence and prospective of plant derived flavonoids as antiplatelet agents: Strong candidates to be drugs of future
No full textPlatelets are involved in hemostasis, inflammation, and thrombosis processes. Following a vascular damage, the endothelium releases protein factors, allowing the adhesion of subendothelium to platelets. Then platelets are activated, leading to the secretion of biologically-active ligands including thromboxane A2, adenosine diphosphate and serotonin. Aspirin, clopidogrel and warfarin are the most common drugs used to meet the challenges of platelet aggregation. However, these agents face issues with aspirin resistance and bleeding. New therapeutically effective and safe agents are therefore strongly needed, and natural substances could be ideal candidates. Flavonoids, a chemically diverse group of polyphenols, might be important in this regard. Consumption of flavonoids is responsible for several health-promoting properties. A number of flavonoids have shown outstanding preclinical antiplatelet effects through various mechanisms. Flavonoids could provide an ideal approach as templates for new, clinically-effective and safe antiplatelet agents due to their inherent safety and multiple useful pharmacological hits. This review aims to report data from literature regarding flavonoids with antiplatelet activity, with a particular focus on possible mechanisms of action, pharmacokinetic profiles and overall safety, thus providing a strong rationale for the design of selective and well-directed antiplatelet agents of natural origin
Mathematics, Logic, and their Philosophies:Essays in Honour of Mohammad Ardeshir
No full textThis volume is a collection of essays in honour of Professor Mohammad Ardeshir. It examines topics which, in one way or another, are connected to the various aspects of his multidisciplinary research interests. Based on this criterion, the book is divided into three general categories. The first category includes papers on non-classical logics, including intuitionistic logic, constructive logic, basic logic, and substructural logic. The second category is made up of papers discussing issues in the contemporary philosophy of mathematics and logic. The third category contains papers on Avicenna’s logic and philosophy.Mohammad Ardeshir is a full professor of mathematical logic at the Department of Mathematical Sciences, Sharif University of Technology, Tehran, Iran, where he has taught generations of students for around a quarter century. Mohammad Ardeshir is known in the first place for his prominent works in basic logic and constructive mathematics. His areas of interest are however much broader and include topics in intuitionistic philosophy of mathematics and Arabic philosophy of logic and mathematics. In addition to numerous research articles in leading international journals, Ardeshir is the author of a highly praised Persian textbook in mathematical logic. Partly through his writings and translations, the school of mathematical intuitionism was introduced to the Iranian academic community
Mathematics, Logic, and their Philosophies:Essays in Honour of Mohammad Ardeshir
No full textThis volume is a collection of essays in honour of Professor Mohammad Ardeshir. It examines topics which, in one way or another, are connected to the various aspects of his multidisciplinary research interests. Based on this criterion, the book is divided into three general categories. The first category includes papers on non-classical logics, including intuitionistic logic, constructive logic, basic logic, and substructural logic. The second category is made up of papers discussing issues in the contemporary philosophy of mathematics and logic. The third category contains papers on Avicenna’s logic and philosophy.Mohammad Ardeshir is a full professor of mathematical logic at the Department of Mathematical Sciences, Sharif University of Technology, Tehran, Iran, where he has taught generations of students for around a quarter century. Mohammad Ardeshir is known in the first place for his prominent works in basic logic and constructive mathematics. His areas of interest are however much broader and include topics in intuitionistic philosophy of mathematics and Arabic philosophy of logic and mathematics. In addition to numerous research articles in leading international journals, Ardeshir is the author of a highly praised Persian textbook in mathematical logic. Partly through his writings and translations, the school of mathematical intuitionism was introduced to the Iranian academic community
Mathematics, Logic, and their Philosophies:Essays in Honour of Mohammad Ardeshir
No full textThis volume is a collection of essays in honour of Professor Mohammad Ardeshir. It examines topics which, in one way or another, are connected to the various aspects of his multidisciplinary research interests. Based on this criterion, the book is divided into three general categories. The first category includes papers on non-classical logics, including intuitionistic logic, constructive logic, basic logic, and substructural logic. The second category is made up of papers discussing issues in the contemporary philosophy of mathematics and logic. The third category contains papers on Avicenna’s logic and philosophy.Mohammad Ardeshir is a full professor of mathematical logic at the Department of Mathematical Sciences, Sharif University of Technology, Tehran, Iran, where he has taught generations of students for around a quarter century. Mohammad Ardeshir is known in the first place for his prominent works in basic logic and constructive mathematics. His areas of interest are however much broader and include topics in intuitionistic philosophy of mathematics and Arabic philosophy of logic and mathematics. In addition to numerous research articles in leading international journals, Ardeshir is the author of a highly praised Persian textbook in mathematical logic. Partly through his writings and translations, the school of mathematical intuitionism was introduced to the Iranian academic community
Mathematics, Logic, and their Philosophies:Essays in Honour of Mohammad Ardeshir
No full textThis volume is a collection of essays in honour of Professor Mohammad Ardeshir. It examines topics which, in one way or another, are connected to the various aspects of his multidisciplinary research interests. Based on this criterion, the book is divided into three general categories. The first category includes papers on non-classical logics, including intuitionistic logic, constructive logic, basic logic, and substructural logic. The second category is made up of papers discussing issues in the contemporary philosophy of mathematics and logic. The third category contains papers on Avicenna’s logic and philosophy.Mohammad Ardeshir is a full professor of mathematical logic at the Department of Mathematical Sciences, Sharif University of Technology, Tehran, Iran, where he has taught generations of students for around a quarter century. Mohammad Ardeshir is known in the first place for his prominent works in basic logic and constructive mathematics. His areas of interest are however much broader and include topics in intuitionistic philosophy of mathematics and Arabic philosophy of logic and mathematics. In addition to numerous research articles in leading international journals, Ardeshir is the author of a highly praised Persian textbook in mathematical logic. Partly through his writings and translations, the school of mathematical intuitionism was introduced to the Iranian academic community
Mathematics, Logic, and their Philosophies:Essays in Honour of Mohammad Ardeshir
No full textThis volume is a collection of essays in honour of Professor Mohammad Ardeshir. It examines topics which, in one way or another, are connected to the various aspects of his multidisciplinary research interests. Based on this criterion, the book is divided into three general categories. The first category includes papers on non-classical logics, including intuitionistic logic, constructive logic, basic logic, and substructural logic. The second category is made up of papers discussing issues in the contemporary philosophy of mathematics and logic. The third category contains papers on Avicenna’s logic and philosophy.Mohammad Ardeshir is a full professor of mathematical logic at the Department of Mathematical Sciences, Sharif University of Technology, Tehran, Iran, where he has taught generations of students for around a quarter century. Mohammad Ardeshir is known in the first place for his prominent works in basic logic and constructive mathematics. His areas of interest are however much broader and include topics in intuitionistic philosophy of mathematics and Arabic philosophy of logic and mathematics. In addition to numerous research articles in leading international journals, Ardeshir is the author of a highly praised Persian textbook in mathematical logic. Partly through his writings and translations, the school of mathematical intuitionism was introduced to the Iranian academic community
'Fatherless' of Mohammad Mosavat: The cultural event of the Iranian spring
No full textThe following is a psychoanalytic commentary about a play recently performed in Tehran (Iran) followed by an interview with its author, Mohammad Mosavat. The co-signatories both attended a performance of this play. Invited by Shahid Behesti, Alzahra, and Shiraz Universities for many public lectures and supervisions, the French psychoanalyst Jean-Luc Vannier signs the commentary while the interview and the translation were conducted by the Iranian psychoanalyst in training at the Freudian Group of Tehran, Mahyar Ali Naghi
Optimizing Maize Productivity and Soil Fertility: Insights from Tillage, Nitrogen Management, and Hydrochar Applications
No full textEnhancing soil fertility and maize productivity is crucial for sustainable agriculture. This study aimed to evaluate the effects of tillage practices, nitrogen management strategies, and acidified hydrochar on soil fertility and maize productivity. The experiment used a randomized complete block design with split-split plot arrangement and four replications. Main plots received shallow tillage and deep tillage. Subplots were treated with nitrogen (120 kg ha−1) from farmyard manure (FYM) and urea, including control, 33% FYM + 67% urea (MU), and 80% FYM + 20% urea (MF). Acidified hydrochar treatments H0 (no hydrochar) and H1 (with hydrochar, 2 t ha−1) were applied to sub-sub plots. Deep tillage significantly increased plant height, biological yield, grain yield, ear length, grains ear−1, thousand-grain weight, and nitrogen content compared to shallow tillage. MU and MF improved growth parameters and yield over the control. Hydrochar effects varied; H1 enhanced yield components and soil properties such as soil organic matter and nitrogen availability compared to H0. Canonical discriminant analysis linked deep tillage and MU/MF nitrogen management with improved yield and soil characteristics. In conclusion, deep tillage combined with integrated nitrogen management enhances maize productivity and soil properties. These findings highlight the importance of selecting appropriate tillage and nitrogen strategies for sustainable maize production along with hydrochar addition. These insights guide policymakers, agronomists, and agricultural extension services in adopting evidence-based strategies for sustainable agriculture, enhancing food production, and mitigating environmental impacts. The implication of this study suggests to undertake long-term application of hydrochar for further clarification and validation
RoMEO Studies 4: An analysis of Journal publishers' Copyright Agreements
Full text linkThis article is the fourth in a series of six emanating from the UK JISC-funded RoMEO Project (Rights Metadata for Open archiving). It describes an analysis of 80 scholarly journal publishers’ copyright agreements with a particular view to their effect on author self-archiving. 90% of agreements asked for copyright transfer and 69% asked for it prior to refereeing the paper. 75% asked authors to warrant that their work had not been previously published although only two explicitly stated that they viewed self-archiving as prior publication. 28.5% of agreements provided authors with no usage rights over their own paper. Although 42.5% allowed self-archiving in some format, there was no consensus on the conditions under which self-archiving could take place. The article concludes that author-publisher copyright agreements should be reconsidered by a working party representing the needs of both partie
Author Correction: Smartphone‑based device for point‑of‑care diagnostics of pulmonary infammation using convolutional neural networks (CNNs)
Full text linkCorrection to: Scientific Reportshttps://doi.org/10.1038/s41598-024-54939-4, published online 22 March 2024 The original version of this Article contained an error in the author name S. Mohammad-Reza Taheri which was incorrectly given as Seyed Mohammad Reza Taheri. In addition, an affiliation was omitted for S. Mohammad-Reza Taheri. The correct affiliations for S. Mohammad-Reza Taheri are listed below. Groningen University, University Medical Center groningen, Antonius Deusinglaan 1, 9713AW Groningen, the Netherlands. Condensed Matter National Laboratory, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran. Moreover, Hossein Simaee was incorrectly affiliated with ‘Institute of Biochemistry and Biophysics, University of Tehran, Tehran 1417614335, Iran’ and ‘Integrated Biophysics and Bioengineering Lab (iBL), Institute of Biochemistry and Biophysics, University of Tehran, Tehran 1417614335, Iran’. The correct affiliation for Hossein Simaee is listed below. Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. The original Article has been corrected.</p
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