740 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Cell Biology, Protein Processing, and Cell Signaling
No full textIn order to perform their multiple functions, eukaryotic cells have evolved an internal structural organization that consists of several organelles and an intricate network of protein filaments, called the cytoskeleton, which determines cell shape and regulates its dynamic changes. Organelles are membrane-bound compartments that play fundamental functions in cellular physiology. The nucleus hosts the DNA and is the site where the genetic information is transcribed into RNA molecules that are processed, transported to the cytoplasm and translated into proteins, the final executers of the genetic program of a cell. The mitochondria are numerous in a cell and responsible of the production of most of the ATP molecules derived from the catabolism of organic compounds but are also involved in Ca++ signalling and cell death pathways. Lysosomes and peroxisomes play specialized functions in the digestion of macromolecules and oxidative and detoxifying reactions. The endoplasmic reticulum (ER) is the site for the synthesis of lipids and proteins destined to be part of the cell membranes or secreted into the extracellular space. Proteins exit the ER and enter the Golgi apparatus that is a central sorting and processing station where proteins are packaged into vesicles for transport to their final destination.
Due to the complexity of such an internal organization, the elucidation of the molecular mechanisms regulating the synthesis, processing and transport of proteins to the various intracellular compartments has fascinated cell biologists for years. Studies on protein secretion have taken advantage of the powerful genetic approaches applied to yeast, a lower eukaryote. A striking evolutionary conservation in the basic components of protein trafficking and processing was found between yeast and mammalian cells.
This chapter will summarize the basic principles of mammalian protein synthesis and processing with a focus on the secretory pathway. Many human proteins that circulate in the blood are secreted and extensively modified by specialized cells and play important functions in human physiology. The findings of many years of research provide the basis for our understanding of the molecular mechanisms of cell biology and how malfunctioning of these processes contributes to human diseases including some haematological disorders
Living green: Conference proceedings of the living green scientific conference
No full textPresentaties van Livinggreen Scientific Conference: Stimulating energy efficiency in households - Comparison of the Livinggreen.eu methods to theory – Daphne Geelen Engaging households in sustainable renovation – Exploration of a complementary approach - Meijer, S.A., Geelen, D.V., Franken, V., Kersten, W.C., Crul. M.R.M From community resilience towards urban resilience: exploring the grassroot initiatives’ role in cities - Meijer, S.A., van Timmeren, A., Crul, M.R.M., Brezet, H.C. Sense of history: capturing and utilizing immaterial values for sustainable heritage protection - Franken, V., Meijer, S.A.Design EngineeringIndustrial Design Engineerin
The New Grand Balloon
No full textArticle about the ascent of Charles Green's balloon on September 23, 1836 from Vauxhall Gardens. Includes an account written by one of the passengers and an account written by Green. An accompanying illustration shows the balloon in the air with the ten passengers and spectators watching from a tower window.For more information about this item, visit https://archivesspace.mit.edu/repositories/2/digital_objects/74
The New Grand Balloon
No full textArticle published in the Weekly Chronicle about the ascent of Charles Green's balloon on September 23, 1836 from Vauxhall Gardens. From an account written by one of the passengers and an account written by Green. An accompanying illustration shows the balloon in the air with the ten passengers and spectators watching from a tower window.For more information about this item, visit https://archivesspace.mit.edu/repositories/2/digital_objects/68
Mayor W.C. Donahue
No full textPhotograph - A member of the Order of the Royal Purple presents a cheque to Mayor William Clifford Donahue for the skating rink fund. Athabasca, Alberta. April 15, 196
The Mosaical account of creation from a strictly scientific standpoint.
No full textWelles, W.C., ex. cl. of 1860.Cover-title.Mode of access: Internet.Copy 1 unbound
Modelonderzoek "Dikke Kop", golfonderzoek haven "Ras Lanuf"
No full textHet is bekend dat de toepassing van een dikke kop aan een golfbreker met verticale wanden invloed heeft op de golfhoogteverdeling achter de golfbreker. Dit onderzoek is verricht om een methode te vinden om deze invloed te bepalen en tevens te verklaren. Nadat dit vooronderzoek is afgerond is er begonnen met een zo economisch mogelijk ontwerp van de haven van Ras Lanuf.Hydraulic EngineeringCivil Engineering and Geoscience
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