53 research outputs found
Gastric antral vascular ectasia: a case report
No full textGastric antral vascular ectasia is a vascular gastric malformation which represents a rare cause of upper gastrointestinal system bleeding. It is usually presented with a significant anemia and it is diagnosed with an endoscopic examination of the upper gastrointestinal system. It is often associated with other chronic illnesses such as liver cirrhosis, sclerodermia, diabetes mellitus and arterial hypertension. It is treated symptomatically in terms of anemia correction with blood transfusions and iron supplements, proton pump inhibitors, beta-blockers and endoscopic procedures such as argon plasma coagulation which currently represents the treatment of choice in Sy. GAVE cases
Increased serum-soluble interleukin-5 receptor alpha level precedes the development of eczema in children
No full textInterleukin-5 receptor alpha-subunit expression may be implicated in the development of allergic diseases. In a population-based birth cohort, we investigated the relationship between IL-5R alpha and the development of allergic phenotypes in childhood, using soluble IL-5R alpha (s-IL-5R alpha) as a marker. Children (n = 510) were followed from birth and assessed at age 3, 5 and 8. Based on the onset and resolution of symptoms, we assigned children into the following wheeze and eczema phenotypes: never, transient, persistent, intermittent and late-onset. Specific IgE to common allergens, s-IL-5R alpha (ELISA) and urinary eosinophilic protein X (U-EPX) levels was measured at age 5. s-IL-5R alpha was significantly higher among atopic compared to non-atopic children (pg/ml, geometric means [95% CI], 152.4 [126.0-184.5] vs. 103.4 [94.0-113.9], p < 0.0001). While we found no association between s-IL-5R alpha and current eczema at age 5, there was a significant association between eczema phenotypes and s-IL-5R alpha (multiple anova model adjusted for gender and atopy, F = 2.56, p = 0.04). After adjustment for multiple comparisons, we found that children with late-onset eczema had significantly higher s-IL-5R alpha compared to those who have never had eczema (mean difference [95% CI], 2.41 [1.03-5.62], p = 0.04) and those with intermittent eczema (2.63 [1.08-6.41], p = 0.02), with no difference between children who have never had eczema and other eczema phenotypes. We found no such association for wheeze phenotypes. There was a weak correlation between s-IL-5R alpha and U-EPX (r = 0.16, p < 0.0001). Increased serum s-IL-5R alpha level at age 5 was associated with contemporaneous atopic sensitization and with subsequent development of eczema by age 8
A polymorphism in gasdermin B (GSDMB) gene is associated with severe asthma exacerbations in childhood: A population-based birth cohort study
No full textRationale. Markers on chromosome 17q12 have been associated withchildhood asthma in genome-wide association studies. Objective.We investigated the association of a single nucleotide polymorphism(SNP) in GSDMB (rs7216389) on 17q12 with asthma presence andseverity in a population-based birth cohort study. Methods. Childrenwere followed from birth to age 8 years. Data on parentally-reportedsymptoms were collected using an interviewer-administered questionnaire at age 1, 3, 5 and 8 years. Atopy was assessed by skin testing at age 3, 5 and 8 years. Information on asthma/wheeze hospital admissions and severe asthma exacerbations was collected from child’s primary care medical record. Data were analyzed as a recessive genetic model, with T-allele homozygotes as the risk group. Results. Compared to C allele carriers, T-allele homozygotes of rs7216389 were significantly more likely to: wheeze at age 3, 5 and 8 years; have persistent wheeze (OR 1.69, 95% CI 1.05-2.71, p=0.03); have frequent episodes of wheezing and be on asthma medication. In a multiple logistic regression model adjusted for gender, atopic sensitisation and maternal smoking, T allele homozygotes were significantly more likely to be hospitalized (aOR 2.20 [1.22-3.99], p=0.0009) with Cox regression hazard ratio for T-allele homozygotes of 1.94 [1.13-3.33], p=0.016. Results of Cox regression analysis investigating the eff ect of genotype on the age of first severe exacerbation of asthma indicated an overall hazard ratio of severe asthma exacerbation among T-allele homozygotes of 1.53 [1.04-2.27], p=0.03. Conclusions. Th is is the fi rst population-based birth cohort study to confirm that the risk of childhood wheeze and severe asthma/wheeze exacerbations is increased among rs7216389 TT homozygotes
O16 - Children with asthma and rhinitis are at a higher risk of asthma exacerbations than children with asthma only: longitudinal analysis
No full textO16 ‐ Children with asthma and rhinitis are at a higher risk of asthma exacerbations than children with asthma only: longitudinal analysis
No full textBreastfeeding and the Development of Asthma and Atopy during Childhood: a Birth Cohort Study.
No full textObjective. Within the context of a population based-birth
cohort, we investigated the association between breastfeeding
and development of asthma and atopy in childhood. Methods. Children (n=1072) were followed from birth and reviewed at age one, three, five and eight years. Based on the onset and resolution of symptoms, we assigned children into the wheeze phenotypes (never, transient, intermittent, lateonset and persistent). Atopy was determined by skin testing and specific IgE measurement. According to the duration of breastfeeding, participants were assigned as not breastfed, breastfed ≤ four months and breastfed > four months. Results. In a multinomial regression model adjusted for gender, we found that breastfeeding > four months was protective of transient early wheeze (aOR: 0.61, 95% CI 0.41-0.90, p=0.01), with no significant association between breastfeeding and other wheeze phenotypes. In a multivariate model, we found a significant protective effect of breastfeeding >four months on doctor-diagnosed asthma by age eight (aOR 0.59, 95% CI 0.39-0.88, p=0.01). However, we observed a strong trend which failed to reach statistical significance for breastfeeding >four months to increase the risk of atopy at age one year (aOR 2.41, 95% CI 0.94-6.14, p=0.07). There was no significant association between breastfeeding and atopy at any other time point. Conclusion. Breastfeeding may prevent viral-infection induced wheezing illnesses in early childhood (transient early wheezing)
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