1,720,998 research outputs found
Nutations in growing plant shoots as a morphoelastic flutter instability
No full textGrowing plant shoots exhibit spontaneous oscillations that Darwin observed, and termed ‘circumnutations’. Recently, they have received renewed attention for the design and optimal actuation of bioinspired robotic devices. We discuss a possible interpretation of these spontaneous oscillations as a Hopf-type bifurcation in a growing morphoelastic rod. Using a three-dimensional model and numerical simulations, we analyse the salient features of this flutter-like phenomenon (e.g. the characteristic period of the oscillations) and their dependence on the model details (in particular, the impact of choosing different growth models) finding that, overall, these features are robust with respect to changes in the details of the growth model adopted
Reazioni indesiderate da anestetici locali: esperienza personale e proposta di un protocollo diagnostico
No full textThe morphological role of ligand inhibitors in blocking receptor- and clathrin-mediated endocytosis
No full textCells often internalize particles through endocytic pathways that involve the binding between cell receptors and particle ligands, which drives the cell membrane to wrap the particle into a delivery vesicle. Previous findings showed that receptor-mediated endocytosis is impossible for spherical particles smaller than a minimum size because of the energy barrier created by membrane bending. In this study, we investigate the morphological role of ligand inhibitors in blocking endocytosis, inspired by antibodies that inhibit virus ligands to prevent infection. While ligand inhibitors have the obvious effect of reducing the driving force due to adhesion, they also have a nontrivial (morphological) impact on the entropic and elastic energy of the system. We determine the necessary conditions for endocytosis by considering the additional energy barrier due to the membrane bending to wrap the inhibiting protrusions. We find that inhibitors increase the minimum radius previously reported, depending on their density and size. In addition, we extend this result to the case of clathrin-mediated endocytosis, which is the most common pathway for virus entry. The assembly of a clathrin coat with a spontaneous curvature increases the energy barrier and sets a maximum particle size (in agreement with experimental observations on spherical particles). Our investigation suggests that morphological considerations can inform the optimal design of neutralizing viral antibodies and new strategies for targeted nanomedicine
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Nickel Allergy: Epidemiology, Pathomechanism, Clinical Patterns, Treatment, and Prevention Programs.
No full textCross-reattività a cefalosporine in soggetti con ipersensibilità “immediata” a amoxicillina: dai test cutanei a testi di scatenamento
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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