91 research outputs found
Bioetica e diritti dell'uomo nella prospettiva del diritto internazionale e comunitario
No full textIl volume espone e commenta le tappe principali della riflessione intrapresa in seno alla Comunità internazionale allo scopo di promuovere una più efficace tutela dell'essere umano nei confronti delle potenzialità applicative delle nuove tecnologie biomediche. La riflessione così avviata ha condotto all'adozione di importanti atti e documenti che, pur dotati di differente forza giuridica, forniscono risposta ai problemi suscitati, nella prospettiva del diritto internazionale e comunitario, dal progresso della tecno-scienza contemporanea
Characterization and comparison of rabbit blastokinin produced under various physiological and experimental conditions
No full textN/
In vitro biosynthesis of rabbit blastokinin
No full textThe authors have incubated, in vitro, estrous rabbit endometrium with 3H-leucine and pseudopregnant rabbit endometrium with 14C-leucine. By the double-labeling technique and the use of the 14C:3H ratio, it was shown that blastokinin (BKN) is neosynthesized in vitro and that this neosynthesis probably also affects other protein components. By ion exchange chromatography of the supernatant of the pseudopregnant endometrium and previously purified BKN, it was possible to confirm the in vitro biosynthesis and to exclude interfering phenomena. Time dynamics showed that biosynthesis was more marked between the 18th and 24th hours of incubation
Clonazione
No full textIl saggio considera le implicazione bioetiche e biogiuridiche del ricorso alle clonazione animale, sottolineando gli aspetti problematici di questa pratica alla luce dell'evoluzione della disciplina italiana e comunitaria in materia e dell'evoluzione delle tecniche utilizzate
[Study and clinical significance of lipid metabolism in pregnancy].
No full text[Study and clinical significance of lipid metabolism in pregnancy]
Common criteria among States for storage and use of dried blood spot specimens after newborn screening
No full textBiological samples collected in biobanks are a resource with significant research potential. The Italian Joint Group cNB - cNBBSV (National committee of Bioethics - National committee for Biosecurity, Biotechnologies and Life Sciences) published a document reporting recommendations on storage and use of dried blood spot (DBS) and on the development of a National Network of Regional Newborn Screening Repositories for collection of residual DBS. Several ethical questions (about consent, possible use of genetic information, unanticipated possible usages for research purposes) rise from residual newborn screening specimens collections. Moreover, legal and ethical controversies are accentuated by the conflicts between the interests of sample donors, biobank holders, researchers and the public. To overcome these difficulties the identification of a few criteria for storage and research usage of DBS is crucial
Human embryo is a human embryo, not a pre-embryo
No full textObjectives: The aim of the study was to investigate the scientific evidence underlying the progressive introduction of the new term “preembryo” in the literature concerning in vitro fertilization and applied preimplantation genetics.
Study Methods: Four approaches to the study of the developing human embryo were considered: genomics, DNA expression, cytologyicytogenetics, and cell differentiation. The relevant recent biomedical literature (1985.1999) was collected and critically examined for the presence of molecular, cytological or hystological data suggesting a documented discontinuity in the development’s process or a significant biological novelty concerning the identity of the newly generated organism. A comparative approach (non-human mammalian development) was also adopted to fill the gap in some investigations concerning the human embryo. Results: No relevant data were found supporting the hypothesis of a genomical or cytological discontinuity between the embryo’s organism at any stage of preimplantation development and the same embryo’s organism during or after the implantation process. Unless the exceptional case of monozygotic twinning, in which a new organism is generated from an existing one, any single formed human embryonic organism is genomically and cytologically related to the same organism
through the cell cycle events. Since the fusion of the two gametes, the zygote is no more cytogenetically working as a maternal cell, even is some time is required before the full expression of the new genome takes place. This temporal condition appears to be the genetic rule of any development during the life of the human organism, and does not represent a characteristic of the early embryo. Conclusions: The distinction between a stage of human development called “pre-embryo” and a stage called “embryo” (proper) is surreptitious since it does not rest on solid scientific evidence of any kind. Therefore it should be dropped out
Ethinylestradiol-chlormadinone acetate combination for the treatment of hirsutism and hormonal alterations of normal-weight women with polycystic ovary syndrome: evaluation of the metabolic impact
No full textThis is the first study evaluating the clinical, metabolic, and hormonal effects of the ethinylestradiol-chlormadinone acetate (EECMA) combination in hirsute women with polycystic ovary syndrome (PCOS). Ultrasonographic pelvic examination, hirsutism score, and hormone profile evaluation were performed at baseline and after 3 and 6 cycles of treatment. Oral glucose tolerance test, euglycemic-hyperinsulinemic clamp, and assessment of lipid profile were carried out at baseline and after 6 cycles of treatment. A significant improvement in hirsutism was evident at the end of treatment. From the third cycle onward, plasma levels of sex hormone binding globulin significantly increased when compared to baseline. Free androgen index, androstenedione, and 17-hydroxyprogesterone significantly decreased after 6 cycles. The treatment did not affect glucose and insulin homeostasis. Total cholesterol, triglycerides, and high-density lipoprotein (HDL) plasma levels remained unvaried, whereas low-density lipoprotein (LDL) concentrations showed a significant reduction. A significant increase in very-low-density lipoprotein (VLDL) levels was seen at the sixth cycle of therapy. In conclusion, EE-CMA combination ameliorates clinical and hormonal features of PCOS women, with no detrimental effects on glucose, insulin, and lipid metabolism
The Publisher and the Author: Valentino Bompiani and Libero Bigiaretti with Unpublished Correspondence
No full textIl presente contributo si propone di ricostruire il sodalizio Fra valentino bompiani e libero bigiaretti, sulla base del carteggio inedito, desunto dall'archivio personale dell'editore e dall'archivio della casa editrice. Nella personlaità dei due protagonisti, e nelle ragioni insite nella rispettiva opera intellettuale, trova adeguata valorizzazione lo scambio umano e professionale intercorso fra l'autore e il suo editore, a partire dai primissimi anni sessanta, in un periodo di importanti cambiamenti dal punto di vista dell'assetto aziendale, che culminerà nel 1973 con la vendita del marchio. Si deve all'indiscusso "protagonismo" dell'editore la peculiarietà del legame con lo scrittore marchigiano (all'amico Valentino questi affidò la ristampa di molte sue opere passate, nonché l'edizione di quelle future), il quale aggiunge tasselli importanti alla ricostruzione di numerosi aspetti: in particolare, trapelano dalle lettere, fra gioie e delusioni, umori e confessioni che bene motivano l'evoluzione creativa e interiore di Bigiaretti nella fase più matura della propria esperienza narrativa, con esiti nuovi soprattutto dal punto di vista espressivo. I numerosi riferimenti, nel carteggio, alla scrittura e alla poetica Bigiarettiana - in un continuo confronto con Bompiani, fido confidente e affascinato lettore - trovano rispondenza nelle stesure autografe dei romanzi in oggetto, comprovando, al contempo, il faticoso labora limae dell'autore.The aim of this work is to rebuild the fellowship between Valentino Bompiani and Libero Bigiaretti on the basis of the unpublished correspondence found in publisher's private archives and publishing house's ones. In the two protagonists' personality, and in the reasons implied in their intellectual work, there is a fair appreciation of the human and professional relationship passed between the author and his publisher starting from the early 70's, a time of important changes in the company structure, which ends with the sell of the brand name in 1973.
It's due to the publisher's undisputed desire to be the centre of attention the peculiarity of the relationship with the author form the Marche (to his friend Valentino he entrusted the reprint of his past works and also the print of the future ones), a relationship that adds important particulars to the reconstruction of many aspects; the letters show especially, among joys and disillusions, moods and confessions that explain, in a clear way, Bigiaretti's creative and inner development in the more mature phase oh his narrative experience, that led to new results above all from the expressive point of view. The large number of references, in the exchange of letters, to Bigiaretti's writing and poetics – in a continuous comparison with Bompiani, faithful confidant and charmed reader – find a correspondence in the drafts (in Bigiaretti's own hand) of the analyzed novels, proving, at the same time, the author's strenuous labour limae
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