441 research outputs found
A genome-wide search replicates evidence of a quantitative trait locus for circulating angiotensisn l-converting enzyme (ACE) unlinked to the ACE gene
No full textBackground: angiotensin I-converting enzyme (ACE) plays an important role in cardiovascular homeostasis. There is evidence from different ethnic groups that circulating ACE levels are influenced by a quantitative trait locus (QTL) at the ACE gene on chromosome 17. The finding of significant residual familial correlations in different ethnic groups, after accounting for this QTL, and the finding of support for linkage to a locus on chromosome 4 in Mexican-American families strongly suggest that there may well be QTLs for ACE unlinked to the ACE gene.Methods: a genome-wide panel of microsatellite markers, and a panel of biallelic polymorphisms in the ACE gene were typed in Nigerian families. Single locus models with fixed parameters were used to test for linkage to circulating ACE with and without adjustment for the effects of the ACE gene polymorphisms.Results: strong evidence was found for D17S2193 (Zmax = 3.5); other nearby markers on chromosome 17 also showed modest support. After adjustment for the effects of the ACE gene locus, evidence of "suggestive linkage" to circulating ACE was found for D4S1629 (Zmax = 2.2); this marker is very close to a locus previously shown to be linked to circulating ACE levels in Mexican-American families.Conclusion: in this report we have provided further support for the notion that there are QTLs for ACE unlinked to the ACE gene; our findings for chromosome 4, which appear to replicate the findings of a previous independent study, should be considered strong grounds for a more detailed examination of this region in the search for genes/variants which influence ACE levels.
The poor yields, thus far, in defining the genetic determinants of hypertension risk suggest a need to look beyond simple relationships between genotypes and the ultimate phenotype. In addition to incorporating information on important environmental exposures, a better understanding of the factors which influence the building blocks of the blood pressure homeostatic network is also required. Detailed studies of the genetic determinants of ACE, an important component of the renin-angiotensin system, have the potential to contribute to this strategic objectiv
sj-docx-1-cpc-10.1177_10556656211036316 - Supplemental material for Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P)
No full textSupplemental material, sj-docx-1-cpc-10.1177_10556656211036316 for Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P) by Lord J. J. Gowans, Carissa L. Comnick, Peter A. Mossey, Mekonen A. Eshete, Wasiu L. Adeyemo, Thirona Naicker, Waheed A. Awotoye, Aline Petrin, Chinyere Adeleke, Peter Donkor, Tamara D. Busch, Olutayo James, Mobolanle O. Ogunlewe, Mary Li, Joy Olotu, Mohaned Hassan, Oluwole A. Adeniyan, Solomon Obiri-Yeboah, Fareed K. N. Arthur, Pius Agbenorku, Alexander A. Oti, Olubukola Olatosi, Olawale O. Adamson, Azeez A. Fashina, Erliang Zeng, Mary L. Marazita, Adebowale A. Adeyemo, Jeffrey C. Murray and Azeez Butali in The Cleft Palate-Craniofacial Journal</p
sj-docx-2-cpc-10.1177_10556656211036316 - Supplemental material for Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P)
No full textSupplemental material, sj-docx-2-cpc-10.1177_10556656211036316 for Genome-Wide Scan for Parent-of-Origin Effects in a sub-Saharan African Cohort With Nonsyndromic Cleft Lip and/or Cleft Palate (CL/P) by Lord J. J. Gowans, Carissa L. Comnick, Peter A. Mossey, Mekonen A. Eshete, Wasiu L. Adeyemo, Thirona Naicker, Waheed A. Awotoye, Aline Petrin, Chinyere Adeleke, Peter Donkor, Tamara D. Busch, Olutayo James, Mobolanle O. Ogunlewe, Mary Li, Joy Olotu, Mohaned Hassan, Oluwole A. Adeniyan, Solomon Obiri-Yeboah, Fareed K. N. Arthur, Pius Agbenorku, Alexander A. Oti, Olubukola Olatosi, Olawale O. Adamson, Azeez A. Fashina, Erliang Zeng, Mary L. Marazita, Adebowale A. Adeyemo, Jeffrey C. Murray and Azeez Butali in The Cleft Palate-Craniofacial Journal</p
Diversion, not detention
No full textThe growing consensus in the UK is that offenders with mental health disorders should be diverted away from custody and into alternatives. Victor Adebowale makes suggestions for a more coherent policy of diversion. Copyright (c) 2010 The Author. Public Policy Research (c) 2010 ippr.
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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
No full textGenome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape
sj-docx-1-cpc-10.1177_10556656221135926 - Supplemental material for Damaging Mutations in <b><i>AFDN</i></b> Contribute to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate
No full textSupplemental material, sj-docx-1-cpc-10.1177_10556656221135926 for Damaging Mutations in AFDN Contribute
to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate by Waheed Awotoye, Peter A Mossey, Jacqueline B Hetmanski, Lord J J Gowans, Mekonen A Eshete and
Wasiu L Adeyemo, Azeez Alade, Erliang Zeng, Olawale Adamson, Olutayo James,
Azeez Fashina, Modupe O Ogunlewe,
Thirona Naicker, Chinyere Adeleke, Tamara Busch,
Mary Li, Aline Petrin, Abimbola Oladayo, Sami Kayali, Joy Olotu, Veronica Sule, Mohaned Hassan, John Pape, Emmanuel T Aladenika, Peter Donkor, Fareed K N Arthur, Solomon Obiri-Yeboah, Daniel K Sabbah, Pius Agbenorku, Debashree Ray,
Gyikua Plange-Rhule, Alexander Acheampong Oti,
Daniah Albokhari, Nara Sobreira, Martine Dunnwald, Terri H Beaty, Margaret Taub, Mary L Marazita,
Adebowale A Adeyemo, Jeffrey C Murray, Azeez Butali in The Cleft Palate-Craniofacial Journal</p
A Preliminary Result of Implementing a Deep Learning-Based Earthquake Early Warning System in Italy
No full textIn this paper we present the preliminary results of a study using a deep-learning tool named LSTM (Long Short-Term Memory) network, to classify seismic events as near-source and far-source, with the final purpose of developing efficient earthquake early warning systems. We use a similar approach as in [15], applied to a database, named Instance, containing information about 54,008 earthquakes that occurred in Italy. Although these are preliminary results, the method shows a good ability to detect far-source events with an accuracy of about 67 %. For near-source events, the method shows an improvable result with an accuracy of 57 %. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG
NMR LABORATORY Introduction with a Time Lapse and Tilt-shift Video
No full textOulu University of Applied Sciences
Degree Programme in Information Technology
Author: Adebowale Babatunde Adejuwon
Title of Bachelor’s thesis: NMR- Laboratory, introduction with a Time Lapse and Tilt-shift video.
Supervisor: Juha Räty
Term and year of completion: Spring 2012 Number of pages: 38
This thesis was based on a very demanding video project for University of Oulu Physic Laboratory NMR group. The objective of the thesis was to make a video to introduce the NMR group in the Physics department at the University of Oulu to young and prospective students. This video editing project was not just about editing, I had to study a lot of very new and demanding programmes that combine video, time lapse and tilt-shift techniques as the aim was to produce a Multimedia style of an interesting video for YouTube and other sources in order to make this NMR laboratory look interesting among young people.
The main video editing tools used in this thesis were Adobe Premiere Pro CS5 for a Windows 64-bit operating system and Adobe After Effects to make time lapse and tilt-shift. Also used was Goldwave which is a digital audio editing software with advanced audio restoration effects and processing tools.
I also learnt how to record videos and deal with robot cameras. The whole process was not just about editing, because it involved writing what happens in the film, some programming, handling both video cameras and time lapse cam-eras, combining audio and video tracks, learning how to take away noises (sur-rounds) from audio tracks, choosing the format suitable for the Internet, a DVD, or whatever sources needed here in the NMR laboratory.
As a result, I made a video about these video effects in DVD and Internet forms for NMR laboratory.Oulun seudun ammattikorkeakoulu
Tietotekniikan koulutusohjelma
Tekijä: Adebowale Babatunde Adejuwon
Opinnäytetyön nimi: NMR-laboratorio, esittely timelapse- ja tilt-shift-tekniikoilla
Työn ohjaaja: Juha Räty
Työn valmistumislukukausi ja -vuosi: Kevät 2012 Sivumäärä: 38
Tämä opinnäytetyö perustuu vaativaan Oulun yliopiston fysiikan laitoksen NMR-laboratorion videoprojektiin. Opinnäytetyön tavoite on luoda esittelyvideo NMR-tutkimuksesta Oulun yliopiston fysiikan laitoksen nuorille ja lupaaville opiskelijoille. Saadaksemme NMR-laboratoriosta kiinnostavan nuorille, tämä videoprojekti ei ollut vain videon editointia. Siihen liittyi uusien ja vaikeiden muokkausohjelmien hallinta yhdistämällä video-, timelapse- ja tilt-shift-liiketekniikoita multimediavideon tuottamiseksi nuorille sopiviin formaatteihin, mm. Youtube-palveluun.
Pääeditointiohjelmina tässä projektissa käytettiin Adobe Premiere Pro CS5 -ohjelmistoa 64-bittiselle Windowsin käyttöjärjestelmälle sekä timelapse- ja tilt-shift-tekniikan toteutukseen Adobe After Effects -ohjelmaa. Lisäksi käytimme Goldwave-nimistä ohjelmaa. Goldwave on digitaalisen äänen muokkausohjelma, josta löytyy edistyneitä äänenkorjaus- ja käsittelytyökaluja.
Työssä perehdyttiin myös videoiden taltiointiin ja robottikameran käyttöön. Projekti ei ole vain videon muokkaamista, koska siihen liittyy myös muistiinpanojen ottamista filmistä, ohjelmointia kuinka hallita videokameraa ja aikavälikameraa yhtäaikaisesti, video- ja ääniraitojen liittämistä, melun erottelemista ääniraidoista ja videon saattamista valmiiksi DVD-, Internet- ja NMR-laboratoriossa tarvittaviin formaatteihin.
Lopputuloksena saatiin paljon videoita DVD:n ja nettivideoiden muodossa NMR-laboratorion käyttöön.
Asiasanat
NMR-laboratorio, Adobe Premiere CS5, videoeditointi, tilt-shift-tekniikka, timelaps
A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus
No full textAbstract Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with variable clinical presentation frequently affecting the skin, joints, haemopoietic system, kidneys, lungs and central nervous system. It can be life threatening when major organs are involved. The full pathological and genetic mechanisms of this complex disease are yet to be elucidated; although roles have been described for environmental triggers such as sunlight, drugs and chemicals, and infectious agents. Cellular processes such as inefficient clearing of apoptotic DNA fragments and generation of autoantibodies have been implicated in disease progression. A diverse array of disease-associated genes and microRNA regulatory molecules that are dysregulated through polymorphism and copy number variation have also been identified; and an effect of ethnicity on susceptibility has been described.</p
Characterization of bacterium types isolated from commercial laying hen farms in Ogun State Nigeria
No full textThis study investigated the distribution of bacterium categories isolated from poultry feces and litters on commercial laying hen farms in Remo and Egba local government areas, Ogun State, Nigeria. In total 29 species of lactose and non-lactose fermenters were recovered. Bacteria isolated from feces included Aeromonas hydrophila (27.5%), Providencia stuartii (15.5%), Actinobacillus sp. (9.1%), Burkholderia cepacia (7.7%), Serratia marcescens (4.9%), Citrobacter diversus (4.9%), Klebsiella oxytoca (4.2%), and Enterobacter gergoviae (4.2%). Others were Escherichia coli (2.1%), Plesiomonas shigelloides (2.1%), Vibrio alginolyticus (2.1%), Morganella morganii (2.1%), Pantoea agglomerans (1.4%), Vibrio mimicus (1.4%), Pseudomonas aeruginosa (1.4%), Burkholderia pseudomallei (1.4%), Salmonella arizonae (0.7%), Klebsiella pneumonia (0.7%), Acinetobacter iwoffii (0.7%), Vibrio vulnificus (0.7%), Shewanella putrefaciens (0.7%), Proteus mirabilis (0.7%) and Proteus vulgaris (0.7%). There was 66.7% similarity between the bacterium profile of litters and that of feces; some additional strains were identified in the litters. No variation (p = 0.64) was observed in the number of isolated bacterium types from feces and litter samples. However, the number of bacterium types isolated from fecal samples differed (p = 0.002) between the two studied areas. Results suggest that there is a potential risk of wide-range bacterial transmission within poultry populations, and to humans in close contact with them
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