654 research outputs found
Reducing the burden of tuberculosis and sepsis in Gabon:Clinical and epidemiological investigations for improved control
No full textEach year, an estimated 1.5 and 11 million people died of tuberculosis and sepsis, respectively. Most cases occur in Low and Middle-Income Countries (LMICs). Gabon is listed in the top 30 tuberculosis/HIV high-burden countries. Studies performed for this thesis investigated the contributors to the burden of tuberculosis and sepsis in Gabon and suggested actions for improved control. Several research designs including a pragmatic clinical trial, systematic review and meta-analysis, cross-sectional, operational and qualitative studies have been combined to generate the outcomes reported in this thesis. The main findings were the following. There is a high prevalence of smoking in tuberculosis patients in Gabon (30%) and smoking is associated with diagnostic delay. Forty-six per cent (46%) of the tuberculosis patients had at least either dyslipidaemia, hypertension, diabetes, or obesity with a majority of newly-diagnosed hypertension and diabetes. One patient out of three with drug-resistant tuberculosis has never been treated for tuberculosis before, highlighting the urgent need to improve drug-resistant tuberculosis case-finding strategies at the community level for early diagnosis and treatment. Almost 64% of HIV-negative patients with tuberculosis sepsis died, and the diagnosis was obtained for 85% of them only post-mortem. Individual sepsis predicting scores such as qSOFA, SIRS, MEWS, and UVA, could not identify sepsis patients with accuracy but should be combined for better performance. Sepsis is a silent killer in many countries. Future research should be designed to provide the evidence needed to engage health policy stakeholders to consider sepsis as a global health priority
MANOVA modelling of a chiropractic longitudinal study using multiple imputation
No full textThe purpose of this report is to present the detailed statistical analysis of a randomised, placebo-controlled trial comparing two different treatment modalities to an intervention of no known benefit for people with acute or subacute thoracic spine pain.
The therapy arms consist of Spinal Manipulative Therapy (SMT) and Graston Technique (GT) and the placebo is a non-functional ultrasound. A placebo group was utilised because at present there are no proven treatments for non-specific thoracic pain. This trial is registered with the Australia and New Zealand Clinical Trials Registry. Ethics approval has been granted by Murdoch University Human Research and Ethics Committee, number 2007/274.
The aim of this three arm trial was to test the efficacy of SMT and GT as independent modalities compared to detuned ultrasound for the outcomes of pain and disability. The latter were measured using the Visual Analogue Scale (VAS) and a modified Oswestry Back Pain Disability Index. The study was conducted at the Murdoch University Chiropractic student clinic in Perth, Australia, and the protocol published in Crothers et al (2008).
In this report, Section 2 provides an initial exploratory analysis of the data, Section 3 outlines the statistical models used in the final analysis, Section 4 defines these models in mathematical terms, Section 5 discusses the management of missing values via multiple imputation and Section 6 presents the results of the statistical modelling and hypothesis tests. The clinical study will be published in full elsewhere
Reducing the burden of tuberculosis and sepsis in Gabon:Clinical and epidemiological investigations for improved control
No full textEach year, an estimated 1.5 and 11 million people died of tuberculosis and sepsis, respectively. Most cases occur in Low and Middle-Income Countries (LMICs). Gabon is listed in the top 30 tuberculosis/HIV high-burden countries. Studies performed for this thesis investigated the contributors to the burden of tuberculosis and sepsis in Gabon and suggested actions for improved control. Several research designs including a pragmatic clinical trial, systematic review and meta-analysis, cross-sectional, operational and qualitative studies have been combined to generate the outcomes reported in this thesis. The main findings were the following. There is a high prevalence of smoking in tuberculosis patients in Gabon (30%) and smoking is associated with diagnostic delay. Forty-six per cent (46%) of the tuberculosis patients had at least either dyslipidaemia, hypertension, diabetes, or obesity with a majority of newly-diagnosed hypertension and diabetes. One patient out of three with drug-resistant tuberculosis has never been treated for tuberculosis before, highlighting the urgent need to improve drug-resistant tuberculosis case-finding strategies at the community level for early diagnosis and treatment. Almost 64% of HIV-negative patients with tuberculosis sepsis died, and the diagnosis was obtained for 85% of them only post-mortem. Individual sepsis predicting scores such as qSOFA, SIRS, MEWS, and UVA, could not identify sepsis patients with accuracy but should be combined for better performance. Sepsis is a silent killer in many countries. Future research should be designed to provide the evidence needed to engage health policy stakeholders to consider sepsis as a global health priority
Reducing the burden of tuberculosis and sepsis in Gabon: Clinical and epidemiological investigations for improved control
No full textEach year, an estimated 1.5 and 11 million people died of tuberculosis and sepsis, respectively. Most cases occur in Low and Middle-Income Countries (LMICs). Gabon is listed in the top 30 tuberculosis/HIV high-burden countries. Studies performed for this thesis investigated the contributors to the burden of tuberculosis and sepsis in Gabon and suggested actions for improved control. Several research designs including a pragmatic clinical trial, systematic review and meta-analysis, cross-sectional, operational and qualitative studies have been combined to generate the outcomes reported in this thesis. The main findings were the following. There is a high prevalence of smoking in tuberculosis patients in Gabon (30%) and smoking is associated with diagnostic delay. Forty-six per cent (46%) of the tuberculosis patients had at least either dyslipidaemia, hypertension, diabetes, or obesity with a majority of newly-diagnosed hypertension and diabetes. One patient out of three with drug-resistant tuberculosis has never been treated for tuberculosis before, highlighting the urgent need to improve drug-resistant tuberculosis case-finding strategies at the community level for early diagnosis and treatment. Almost 64% of HIV-negative patients with tuberculosis sepsis died, and the diagnosis was obtained for 85% of them only post-mortem. Individual sepsis predicting scores such as qSOFA, SIRS, MEWS, and UVA, could not identify sepsis patients with accuracy but should be combined for better performance. Sepsis is a silent killer in many countries. Future research should be designed to provide the evidence needed to engage health policy stakeholders to consider sepsis as a global health priority
Reducing the burden of tuberculosis and sepsis in Gabon: Clinical and epidemiological investigations for improved control
No full textEach year, an estimated 1.5 and 11 million people died of tuberculosis and sepsis, respectively. Most cases occur in Low and Middle-Income Countries (LMICs). Gabon is listed in the top 30 tuberculosis/HIV high-burden countries. Studies performed for this thesis investigated the contributors to the burden of tuberculosis and sepsis in Gabon and suggested actions for improved control. Several research designs including a pragmatic clinical trial, systematic review and meta-analysis, cross-sectional, operational and qualitative studies have been combined to generate the outcomes reported in this thesis. The main findings were the following. There is a high prevalence of smoking in tuberculosis patients in Gabon (30%) and smoking is associated with diagnostic delay. Forty-six per cent (46%) of the tuberculosis patients had at least either dyslipidaemia, hypertension, diabetes, or obesity with a majority of newly-diagnosed hypertension and diabetes. One patient out of three with drug-resistant tuberculosis has never been treated for tuberculosis before, highlighting the urgent need to improve drug-resistant tuberculosis case-finding strategies at the community level for early diagnosis and treatment. Almost 64% of HIV-negative patients with tuberculosis sepsis died, and the diagnosis was obtained for 85% of them only post-mortem. Individual sepsis predicting scores such as qSOFA, SIRS, MEWS, and UVA, could not identify sepsis patients with accuracy but should be combined for better performance. Sepsis is a silent killer in many countries. Future research should be designed to provide the evidence needed to engage health policy stakeholders to consider sepsis as a global health priority
Reducing the burden of tuberculosis and sepsis in Gabon:Clinical and epidemiological investigations for improved control
No full textEach year, an estimated 1.5 and 11 million people died of tuberculosis and sepsis, respectively. Most cases occur in Low and Middle-Income Countries (LMICs). Gabon is listed in the top 30 tuberculosis/HIV high-burden countries. Studies performed for this thesis investigated the contributors to the burden of tuberculosis and sepsis in Gabon and suggested actions for improved control. Several research designs including a pragmatic clinical trial, systematic review and meta-analysis, cross-sectional, operational and qualitative studies have been combined to generate the outcomes reported in this thesis. The main findings were the following. There is a high prevalence of smoking in tuberculosis patients in Gabon (30%) and smoking is associated with diagnostic delay. Forty-six per cent (46%) of the tuberculosis patients had at least either dyslipidaemia, hypertension, diabetes, or obesity with a majority of newly-diagnosed hypertension and diabetes. One patient out of three with drug-resistant tuberculosis has never been treated for tuberculosis before, highlighting the urgent need to improve drug-resistant tuberculosis case-finding strategies at the community level for early diagnosis and treatment. Almost 64% of HIV-negative patients with tuberculosis sepsis died, and the diagnosis was obtained for 85% of them only post-mortem. Individual sepsis predicting scores such as qSOFA, SIRS, MEWS, and UVA, could not identify sepsis patients with accuracy but should be combined for better performance. Sepsis is a silent killer in many countries. Future research should be designed to provide the evidence needed to engage health policy stakeholders to consider sepsis as a global health priority
Reducing the burden of tuberculosis and sepsis in Gabon:Clinical and epidemiological investigations for improved control
No full textEach year, an estimated 1.5 and 11 million people died of tuberculosis and sepsis, respectively. Most cases occur in Low and Middle-Income Countries (LMICs). Gabon is listed in the top 30 tuberculosis/HIV high-burden countries. Studies performed for this thesis investigated the contributors to the burden of tuberculosis and sepsis in Gabon and suggested actions for improved control. Several research designs including a pragmatic clinical trial, systematic review and meta-analysis, cross-sectional, operational and qualitative studies have been combined to generate the outcomes reported in this thesis. The main findings were the following. There is a high prevalence of smoking in tuberculosis patients in Gabon (30%) and smoking is associated with diagnostic delay. Forty-six per cent (46%) of the tuberculosis patients had at least either dyslipidaemia, hypertension, diabetes, or obesity with a majority of newly-diagnosed hypertension and diabetes. One patient out of three with drug-resistant tuberculosis has never been treated for tuberculosis before, highlighting the urgent need to improve drug-resistant tuberculosis case-finding strategies at the community level for early diagnosis and treatment. Almost 64% of HIV-negative patients with tuberculosis sepsis died, and the diagnosis was obtained for 85% of them only post-mortem. Individual sepsis predicting scores such as qSOFA, SIRS, MEWS, and UVA, could not identify sepsis patients with accuracy but should be combined for better performance. Sepsis is a silent killer in many countries. Future research should be designed to provide the evidence needed to engage health policy stakeholders to consider sepsis as a global health priority
Experimental characterisation of self-healing in reconstituted Boom Clay
No full textGreen Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Geo-engineerin
The Methodological Reflection about the Criticism to Hu Hong in The Doubt of Zhi Yan by Zhu Hsi
No full text本文討論《知言疑義》中朱熹對胡宏的批評意見，企圖澄清兩造思路的差異，從而各自呈現兩家思維的特色與要點。《知言疑義》中胡宏的文句多半是本體工夫論合構的發言，因此語多跳躍，致引朱熹之批評。朱熹即由性善論的本體論立場批評胡宏有「性無善惡」之說，及由存有論思路的「心統性情說」批評胡宏的心性相關語句之不佳，以及由「未發涵養已發察識」的工夫次第思路批評胡宏並未重視平日涵養一節。本文將藉由作者所提之「實踐哲學的解釋架構」，以及「存有論哲學」的問題意識分析，以澄清兩造哲學問題意識的不同，因而並未形成真正的衝突，從而亦藉此說明朱熹與胡宏各自論學之重點意旨。The discussion in this article is about the criticism to Hu Hong in The doubt of Zhi yan Proposed by Zhu Hsi. The author is aiming to clear the dissimilar way of thinking between the two philosophers to the effect that both their significant theory could be appeared. Hu Hong’s philosophical announcement always integrates the ontological and practical theory, which results to the ambiguity and give rise to the criticism from Zhu Hsi. Zhu Hsi possessed the position of the goodness of nature to query Hu Hong about his no good and no evil opinion toward the theory of the human nature. In the definition of the mind and nature, master Zhu Hsi proposed the mind comprise the nature and the felling and argued with Hu Hong’s different opining. Concerning about the practical procedure theory, Zhu Hsi insist the cultivation should be built on daily life, and critic Hu Hong’s philosophy being short of this understanding. In this article the author will use the interpretational structure of the practical theory and the theory of being to analyze the different consciousness in these two systems and suggest that there exist no real conflict between them so as to explain both their philosophical thinking
St. Scholastica's interactive timeline exhibition
No full textCurrently, the information on the history of the Benedictine Sisters and St. Scholastica's College is scattered around in various PowerPoint presentations, websites, and off course books and other analog media. For the Museum Archives, a more structured exhibition is aimed for, allowing visitors to browse the history of the Philippines, the Benedictine sisters and St. Scholastica's College in the past 100 years. This interactive exhibit will be the center piece of the Museum Archives of the Missionary Benedictine Sisters in the Philippines. We are to design such a system, and start to implement it. Also, we should ensure continuity of the project by making the staff familiar with the system. This way they can take it along after we are gone, maintaining it as its database growsElectrical Engineering, Mathematics and Computer Scienc
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