1,720,969 research outputs found
Effect of exercise-induced muscle damage on vascular function and skeletal muscle microvascular deoxygenation
Get PDFCitation: Caldwell, J. T., Wardlow, G. C., Branch, P. A., Ramos, M., Black, C. D., & Ade, C. J. (2016). Effect of exercise-induced muscle damage on vascular function and skeletal muscle microvascular deoxygenation. Physiological Reports, 4(22), 12. doi:10.14814/phy2.13032This paper investigated the effects of unaccustomed eccentric exercise-induced muscle damage (EIMD) on macro-and microvascular function. We tested the hypotheses that resting local and systemic endothelial-dependent flow-mediated dilation (FMD) and microvascular reactivity would decrease, (V) over dotO(2max) would be altered, and that during ramp exercise, peripheral O-2 extraction, evaluated via near-infrared-derived spectroscopy (NIRS) derived deoxygenated hemoglobin + myoglobin ([HHb]), would be distorted following EIMD. In 13 participants, measurements were performed prior to (Pre) and 48 h after a bout of knee extensor eccentric exercise designed to elicit localized muscle damage (Post). Flow-mediated dilation and postocclusive reactive hyperemic responses measured in the superficial femoral artery served as a measurement of local vascular function relative to the damaged tissue, while the brachial artery served as an index of nonlocal, systemic, vascular function. During ramp-incremental exercise on a cycle ergometer, [HHb] and tissue saturation (TSI%) in the m. vastus lateralis were measured. Superficial femoral artery FMD significantly decreased following EIMD (pre 6.75 +/- 3.89%; post 4.01 +/- 2.90%; P 0.05). At each progressive increase in workload (i.e., 0-100% peak), the [HHb] and TOI% responses were similar pre-and 48 h post-EIMD (P > 0.05). Additionally, (V) over dotO(2max) was similar at pre-(3.0 +/- 0.67 L min(-1)) to 48 h post (2.96 +/- 0.60 L min(-1))-EIMD (P > 0.05). Results suggest that moderate eccentric muscle damage leads to impaired local, but not systemic, macrovascular dysfunction
W ' expenditure and reconstitution during severe intensity constant power exercise: mechanistic insight into the determinants of W '
No full textCitation: Broxterman, R. M., Skiba, P. F., Craig, J. C., Wilcox, S. L., Ade, C. J., & Barstow, T. J. (2016). W ' expenditure and reconstitution during severe intensity constant power exercise: mechanistic insight into the determinants of W '. Physiological Reports, 4(19), 9. doi:10.14814/phy2.12856The sustainable duration of severe intensity exercise is well-predicted by critical power (CP) and the curvature constant (W'). The development of the W-BAL' model allows for the pattern of W' expenditure and reconstitution to be characterized and this model has been applied to intermittent exercise protocols. The purpose of this investigation was to assess the influence of relaxation phase duration and exercise intensity on W' reconstitution during dynamic constant power severe intensity exercise. Six men (24.6 +/- 0.9 years, height: 173.5 +/- 1.9 cm, body mass: 78.9 +/- 5.6 kg) performed severe intensity dynamic handgrip exercise to task failure using 50% and 20% duty cycles. The W-BAL' model was fit to each exercise test and the time constant for W' reconstitution (tau(W)') was determined. The sW' was significantly longer for the 50% duty cycle (1640 +/- 262 sec) than the 20% duty cycle (863 +/- 84 sec, P = 0.02). Additionally, the relationship between sW' and CP was well described as an exponential decay (r(2) = 0.90, P < 0.0001). In conclusion, the W-BAL' model is able to characterize the expenditure and reconstitution of W' across the contraction-relaxation cycles comprising severe intensity constant power handgrip exercise. Moreover, the reconstitution of W' during constant power severe intensity exercise is influenced by the relative exercise intensity, the duration of relaxation between contractions, and CP
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Altered Blood Flow Response to Small Muscle Mass Exercise in Cancer Survivors Treated With Adjuvant Therapy
Get PDFCitation: Didier, K. D., Ederer, A. K., Reiter, L. K., Brown, M., Hardy, R., Caldwell, J., . . . Ade, C. J. (2017). Altered Blood Flow Response to Small Muscle Mass Exercise in Cancer Survivors Treated With Adjuvant Therapy. Journal of the American Heart Association, 6(2), 9. doi:10.1161/jaha.116.004784Background-Adjuvant cancer treatments have been shown to decrease cardiac function. In addition to changes in cardiovascular risk, there are several additional functional consequences including decreases in exercise capacity and increased incidence of cancer-related fatigue. However, the effects of adjuvant cancer treatment on peripheral vascular function during exercise in cancer survivors have not been well documented. We investigated the vascular responses to exercise in cancer survivors previously treated with adjuvant cancer therapies. Methods and Results-Peripheral vascular responses were investigated in 11 cancer survivors previously treated with adjuvant cancer therapies (age 58 +/- 6 years, 34 +/- 30 months from diagnosis) and 9 healthy controls group matched for age, sex, and maximal voluntary contraction. A dynamic handgrip exercise test at 20% maximal voluntary contraction was performed with simultaneous measurements of forearm blood flow and mean arterial pressure. Forearm vascular conductance was calculated from forearm blood flow and mean arterial pressure. Left ventricular ejection time index (LVETi) was derived from the arterial pressure wave form. Forearm blood flow was attenuated in cancer therapies compared to control at 20% maximal voluntary contraction (189.8 +/- 53.8 vs 247.9 +/- 80.3 mL.min (1), respectively). Forearm vascular conductance was not different between groups at rest or during exercise. Mean arterial pressure response to exercise was attenuated in cancer therapies compared to controls (107.8 +/- 10.8 vs 119.2 +/- 16.2 mm Hg). LEVTi was lower in cancer therapies compared to controls. Conclusions-These data suggest an attenuated exercise blood flow response in cancer survivors approximate to 34 months following adjuvant cancer therapy that may be attributed to an attenuated increase in mean arterial pressure
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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