4,709 research outputs found
Depressive disorders co-existing with Addison–Biermer anemia – case report
No full textMark Jean Just,1 Mariusz Kozakiewicz2 1Department of General and Endocronological Surgery, Piekary Medical Centre, Piekary Slaskie, 2Department of Food Chemistry Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Torun, Poland Background: Anemia is a disease that can co-exist with depression, other mental disorders, or somatic diseases. Anemia can imitate symptoms of depression, while depression symptoms can mask concurring symptoms of anemia.Case presentation: I am presenting a case of a 48-year-old woman with Addison–Biermer anemia, with co-existing mood disorders. The clinical analysis of the presented patient’s history indicates diagnostic problems and a need for a detailed analysis of drug-related complications that occurred during previous treatment, eg, in the form of neuroleptic malignant syndrome.Conclusion: The presented case report contains valuable guidelines that can be of assistance in diagnostics and treatment of patients treated for mental disorders, who are also diagnosed with somatic diseases. Keywords: anemia, autoimmune diseases, depression, neuroleptic malignant syndrom
Self-compression of 4.9 µm pulses to sub-40 fs with 2 mJ energy in Zinc Sulfide
No full textNonlinear self-compression of few-cycle multi-mJ pulses at 4.9 µm in ZnS is presented. 80 fs input pulses are compressed to 37 fs with 2.1 mJ energy at a 1 kHz repetition rate. © 2024 The Author(s
Correction to: Chamoun et al., Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection
No full textChamoun MN, Blumenthal A, Sullivan MJ, Schembri MA, Ulett GC. 2018. Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection. Critical Reviews in Microbiology. https://doi.org/10.1080/1040841X.2018.1426556.
When the above article was first published online, the below three corrections were missed.
The author ‘Antje Blumenthal’ was wrongly affiliated to the affiliation “cSchool of Chemistry and Molecular Biosciences, and Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, Australia”. Now this affiliation has been removed for this author.
The affiliation ‘bTranslational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia’ of the author ‘Antje Blumenthal’ should read ‘bThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia’.
In Table 3, the sentence ‘Benefit of manipulating IL-17 levels to improve immunization strategies M. tuberculosis’ should read “Benefit of manipulating IL-17 levels to improve immunization strategies against M. tuberculosis”.No Full Tex
Generation of 22-mJ, 2.0-ps Pulses from a 1-kHz Ho:YLF Regenerative Chirped Pulse Amplifier
No full textWe report a CW-pumped Ho:YLF regenerative amplifier (RA) delivering pulses with 22.5-mJ energy and 2.0-ps duration at 1 kHz. The RA emitting at 2051 nm is broadband-seeded and implemented in a chirped pulse amplification system. © 2024 The Author(s
Design for manufacture: a methodology to evaluate an aircraft design in order to ensure its manufacturability
No full textThe aim of the research is to develop a methodological analysis of problems in the
area of design for manufacture in low volume high complex products found in the
writer’s workplace. The majority of research in this area has been around high
volume products, such as automotive products and little consideration has been given
to designing complex products from industries like aircraft manufacture.
This research evaluates design for manufacture (DFM) information in the design lifecycle
(DLC). The author’s research introduces a unique DLC process, one which
structures decisions and data transfer through the DLC. The research also looks at
current academic work and introduces industrial issues present in today’s
environment.
It is crucial to the design of a product to select the appropriate design environment in
which it operates, as it will structure the way the engineering activities are established
and developed. It is also important for the organisation to decide on the environment
in which the design definition should evolve. Therefore the research reviews the
different design definition environments, these were carefully analysed by the author.
The evaluation of a design to ensure its manufacturability is a major element in the
research, a review of previous work has highlighted that within current publications
there has been little work in this area. The research has developed a methodology to
evaluate the robustness of a design. It not only looks at the engineering design but
also evaluates its adherence to customer requirements and the effect on cost for the
overall product life-cycle. It also considers industrial needs for a reduction in the
length of design life-cycle, while ensuring a reduction in manufacturing costs. There
are two main contributors to this, firstly the use of key characteristics and secondly,
the ability to control the manufacturability of a design. The author has developed a
novel software tool enabling efficient evaluation of a design.
The author discusses his contribution to existing knowledge in three main areas of the
research. The most significant being the introduction of a tool to evaluate a design
early in the design life-cycle to ensure manufacturability. To validate the research the
author introduces the reader to three experimental phases. He validates his
methodology by analysing the design of various aircraft assemblies discussing his
findings of how manufacturable the designs are. This leads to the conclusion that the
author’s research adds substantial knowledge to the area of design for manufacture
arules - A Computational Environment for Mining Association Rules and Frequent Item Sets
No full textMining frequent itemsets and association rules is a popular and well researched approach for discovering interesting relationships between variables in large databases. The R package arules presented in this paper provides a basic infrastructure for creating and manipulating input data sets and for analyzing the resulting itemsets and rules. The package also includes interfaces to two fast mining algorithms, the popular C implementations of Apriori and Eclat by Christian Borgelt. These algorithms can be used to mine frequent itemsets, maximal frequent itemsets, closed frequent itemsets and association rules.
Pure-rotational 1D-CARS spatiotemporal thermometry with a single regenerative amplifier system
No full textWe report spatiotemporal pure-rotational coherent anti-Stokes Raman spectroscopy (CARS) in a one-dimensional imaging arrangement obtained with a single ultrafast regenerative amplifier system. The femtosecond pump/Stokes photon pairs, used for impulsive excitation, are delivered by an external compressor operating on a ∼35% beam split of the uncompressed amplifier output (2.5 mJ/pulse). The picosecond 1.2 mJ probe pulse is produced via the second-harmonic bandwidth compression (SHBC) of the ∼65% remainder of the amplifier output (4.5 mJ/pulse), which originates from the internal compressor. The two pump/Stokes and probe pulses are spatially, temporally, and repetition-wise correlated at the measurement, and the signal generation plane is relayed by a wide-field coherent imaging spectrometer onto the detector plane, which is refreshed at the same repetition rate as the ultrafast regenerative amplifier system. We demonstrate 1 kHz cinematographic 1D-CARS gas-phase thermometry across an unstable premixed methane/air flame-front, achieved with a single-shot precision <1% and accuracy <3%, 1.4 mm field of view, and an excellent <20 µm line-spread function.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Flight Performance and Propulsio
arules - A Computational Environment for Mining Association Rules and Frequent Item Sets
No full textMining frequent itemsets and association rules is a popular and well researched approach
for discovering interesting relationships between variables in large databases. The
R package arules presented in this paper provides a basic infrastructure for creating and
manipulating input data sets and for analyzing the resulting itemsets and rules. The package
also includes interfaces to two fast mining algorithms, the popular C implementations
of Apriori and Eclat by Christian Borgelt. These algorithms can be used to mine frequent
itemsets, maximal frequent itemsets, closed frequent itemsets and association rules. (authors' abstract
MOA-2007-BLG-197 : exploring the brown dwarf desert
No full textA.C. acknowledges financial support from the Emergence UPMC 2012 grant. Work by C.H. was supported by Creative Research Initiative Program (2009-0081561) of National Research Foundation of Korea. K.H., M.D. and M.H. are supported by NPRP grant NPRP-09-476-1-78 from the Qatar National Research Fund (a member of Qatar Foundation). M.H. acknowledges support from the Villum foundation. S.D. is supported by “the Strategic Priority Research Program- The Emergence of Cosmological Structures” of the Chinese Academy of Sciences (grant No. XDB09000000).We present the analysis of MOA-2007-BLG-197Lb, the first brown dwarf companion to a Sun-like star detected through gravitational microlensing. The event was alerted and followed-up photometrically by a network of telescopes from the PLANET, MOA, and μFUN collaborations, and observed at high angular resolution using the NaCo instrument at the VLT. From the modelling of the microlensing light curve, we derived basic parameters such as, the binary lens separation in Einstein radius units (s ≃ 1.13), the mass ratio q = (4.732 ± 0.020) × 10-2 and the Einstein radius crossing time (tE ≃ 82 d). Because of this long time scale, we took annual parallax and orbital motion of the lens in the models into account, as well as finite source effects that were clearly detected during the source caustic exit. To recover the lens system’s physical parameters, we combined the resulting light curve best-fit parameters with (J,H,Ks) magnitudes obtained with VLT NaCo and calibrated using IRSF and 2MASS data. From this analysis, we derived a lens total mass of 0.86 ± 0.04 M⊙ and a lens distance of DL = 4.2 ± 0.3 kpc. We find that the companion of MOA-2007-BLG-197L is a brown dwarf of 41 ± 2 MJ observed at a projected separation of a⊥ = 4.3 ± 0.1 AU, and orbits a 0.82 ± 0.04 M⊙ G-K dwarf star. We then placed the companion of MOA-2007-BLG-197L in a mass-period diagram consisting of all brown dwarf companions detected so far through different techniques, including microlensing, transit, radial velocity, and direct imaging (most of these objects orbit solar-type stars). To study the statistical properties of this population, we performed a two-dimensional, non-parametric probability density distribution fit to the data, which draws a structured brown dwarf landscape. We confirm the existence of a region that is strongly depleted in objects at short periods and intermediate masses (P ≲ 30 d, M ∼ 30 − 60 MJ), but also find an accumulation of objects around P ∼ 500 d and M ∼ 20 MJ, as well as another depletion region at long orbital periods (P ≳ 500 d) and high masses (M ≳ 50 MJ). While these data provide important clues on the different physical mechanisms of formation (or destruction) that shape the brown dwarf desert, more data are needed to establish their relative importance, in particular as a function of host star mass. Future microlensing surveys should soon provide more detections, in particular for red dwarf hosts, thus uniquely complementing the solar-type host sample.Peer reviewe
Project: Establishing an accounting outsourcing company "MJ Grāmatvedība" Ltd
No full textProjekta ideja ir izveidot grāmatvedības ārpakalpojumu uzņēmumu SIA „MJ Grāmatvedība”, kurš sniegtu pilna vai daļēja cikla grāmatvedības pakalpojumus, sākot ar pirmreizējo dokumentu apstrādi un beidzot ar visu nepieciešamo atskaišu sagatavošanu, kā arī konsultāciju sniegšanu. Projekta mērķis ir ne tikai sniegt grāmatvedības pakalpojumus, bet arī analizēt uzņēmumu darbību un izstrādāt ieteikumus darbības uzlabošanai. Darba autore uzskata, ka nozares pārstāvjiem ir būtiski jāpierāda sava nozīme un to kādam jābūt mūsdienu grāmatvedim. Grāmatvedis nav tikai persona, kura izdara konkrētus darbus, nodos atskaites, tas ir cilvēks, kuram labi jāpārzina nodokļu sistēma, finanšu vadīšana, jāspēj sniegt padomus uzņēmuma finanšu vadības uzlabošanai, kā arī jāspēj pielāgoties tehnoloģiju radītajām izmaiņām. Maģistra darbs apjoms ir uz 105 lappusēm, kas sastāv no 7 nodaļām, 17 pielikumiem, 22 tabulām un 7 attēliem. Darba izstrādē izmantoti 70 informācijas avoti.The general project idea is to establish the accountancy firm MJ Accountancy Ltd., which would provide full or half-cycle accountancy services including the processing of primary documentation, reports’ preparation, and providing of the accountancy consultations. The aim of the project is not only to provide accountancy consultations but also to deal with firms activity analysis and developing suggestions on their activity improvement. The author of the project supports the idea that the field representatives must constantly sustain the status of the accountant’s profession in current times. The accountant is not only the person who executes one’s regular duties and submits reports, but also the person who is competent in the field of taxes, financial management, able to advise on improvements in financial management, and above all able to adapt to the technological changes. The volume of the project is 105 pages, which includes 7 chapters, 17 appendices, 22 tables, 7 figures. 70 sources of information were used in master’s thesis
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