6,096 research outputs found
Vacuum Insulation Panels Applied in Building Constructions
No full textDue to sustainability and due to international treaties, it is desired and required to reduce greenhouse gas emissions drastically. One contributor to these emissions is the burning of fossil fuels for generating power and electricity to be used in and for buildings. Buildings and building-related processes are responsible for about 40% of the primary energy consumption in the European Union. More than half of this energy is applied for heating systems in dwellings and commercial buildings. The European Union therefore has laid down new energy performance requirements for buildings in the European Directive on the Energy Performance of Buildings. Moreover, a reduction of energy losses of buildings during their occupational phase is important for facilitating the implementation of sustainable energy sources in the built environment. Increasing the insulation value of the envelope of buildings may contribute to this reduction of primary energy use. Two strategies can be followed. The first strategy is to increase the thickness of the thermal insulation layer. Until recently, this strategy has primarily been adopted. If, however, German or Swiss Passivhaus standard is applied, the thickness of this insulation layer would increase to beyond 30 cm, resulting in very thick building enclosures. The second, more innovative, strategy for reducing energy losses through the building skin would be the application of more effective thermal insulators. One such more effective thermal insulator is a vacuum insulation panel, abbreviated as VIP. A VIP consists of an open-celled core material which is evacuated and then tightly sealed into a barrier envelope to maintain this vacuum. The vacuum inside the pores of the core material reduces the thermal conductivity of the product significantly, as a result of which the thickness of the insulation layer can be reduced to obtain a certain performance. This reduction of thickness is among the most promising features for large-scale application of VIPs in the building industry. However, integration of VIPs into buildings must be performed very meticulously for several reasons; first, due to its nature a VIP cannot be processed on site and needs careful planning in advance; second, it is very sensitive to mechanical damage thus requiring careful handling; third, thermal bridges along the panel’s edges reduce its performance; fourth, the composite system is highly subjected to aging. This dissertation therefore looks into many of these aspects, presents several calculation tools and shows how VIPs can be applied in façade panels, EPS insulation boards and as under-floor insulation. With the wide-spread proliferation of VIPs in buildings a more sustainable and healthy environment can then be achieved.Building TechnologyArchitectur
A systematic review of evidence for the appropriateness of neonatal screening programmes for inborn errors of metabolism
No full textBackground: developments in screening technology and increased understanding of the natural history and treatment of inborn errors of metabolism (IEMs) have produced pressure to extend neonatal screening programmes. This review aims to assess the evidence for the appropriateness of such programmes. Methods: a formal systematic literature review was conducted. Exclusion and inclusion criteria were used to select papers for critical appraisal by pairs of reviewers. Standard criteria were used to assess the appropriateness of neonatal screening for various IEMs. Site visits were conducted to assess new technologies for newborn screening. Results: a total of 1866 papers were identified and 407 systematically selected for full critical appraisal. Published evidence confirmed that universal newborn screening for phenylketonuria (PKU) meets all of the screening criteria and justifies the expense and infrastructure necessary for the collection and testing of neonatal blood spots. There was insufficient evidence in the literature to assess the cost-effectiveness of screening for any other IEMs. There was reasonable evidence to support inclusion in extended neonatal screening of four other IEMs: biotinidase deficiency, congenital adrenal hyperplasia (CAH), medium-chain acyl CoA dehydrogenase (MCAD) deficiency and glutaric aciduria type 1 (GA1). Conclusions: large-scale trials of screening for biotinidase, CAH, MCAD and GA1 should be conducted, with careful evaluation to establish their clinical effectiveness and cost-effectiveness in practice. Screening for the latter two disorders would be dependent upon the use of tandem mass spectrometry (tandem MS). The application of tandem MS to newborn screening requires further evaluation. The extension of neonatal screening programmes to other IEMs is not currently justifie
Secondary analysis of economic data: a review of cost-benefit studies of neonatal screening for phenylketonuria
No full textStudy objective: to estimate the net financial benefit of neonatal screening for phenylketonuria (PKU): by a simple pooling of cost data from the literature; and by a more complex modelling approach. Design: a systematic literature review was conducted to identify papers containing data on the monetary costs and benefits of neonatal screening for PKU. The methodological quality of the studies was appraised, and data were extracted on resource use and expenditure. Monetary data were converted to common currency units, and standardised to UK incidence rates. Net benefits were calculated for median, best case and worst case scenarios, and the effect of excluding poor quality studies and data was tested. The net benefit was also estimated from a model based on data from the literature and assumptions appropriate for the current UK situation. Extensive sensitivity analysis was conducted.Main results: the direct net benefit of screening based on the median costs and benefits from the 13 studies identified was 143,400 Pounds per case detected and treated (39,000 Pounds and 241,800 Pounds for worst case and best case scenarios respectively). The direct net benefit obtained by the modelling approach was lower at 93,400 Pounds per case detected and treated. Screening remained cost saving under sensitivity analysis, except with low residential care costs (less than 12,300 Pounds per annum), or very low incidence rates (less than 1 in 27,000). Conclusions: the economic literature on PKU screening is of variable quality. The two methods of secondary analysis lead to the same conclusion: that neonatal PKU screening is worthwhile in financial terms alone in the UK, and that it justifies the infrastructure for collecting and testing neonatal blood samples. This result cannot necessarily be extrapolated to other countrie
Predicting grain refinement by cold severe plastic deformation in alloys using volume average dislocation generation
No full textThe grain refinement during severe plastic deformation (SPD) is predicted using volume averaged amount of dislocations generated. The model incorporates a new expansion of a model for hardening in the parabolic hardening regime, in which the work hardening depends on the effective dislocation free path related to the presence of non shearable particles and solute-solute nearest neighbour interactions. These two mechanisms give rise to dislocation multiplication in the form of generation of geometrically necessary dislocations and dislocations induced by local bond energies. The model predicts the volume averaged amount of dislocations generated and considers that they distribute to create cell walls and move to existing cell walls/grain boundaries where they increase in the grain boundary misorientation. The model predicts grain sizes of Al alloys subjected to SPD over 2 orders of magnitude. The model correctly predicts the considerable influence of Mg content and content of non-shearable particles on the grain refinement during SPD
Book Review: Reginald M.J. Oduor’s Introduction to Ethics
No full textTITLE OF BOOK: Introduction to Ethics
AUTHOR: Reginald M.J. Oduor
Nairobi: Sophia Publications Ltd., 2009, 116 pages
COVER: Paperback
ISBN: 9966-7457-0-X
This book is a product of more than a decade of Oduor’s experience in teaching ethics (moral philosophy) at the University of Nairobi. In the course of this introduction, the reader gets to see the techniques of philosophic reflection in action, as they are employed to scrutinise various pertinent moral questions
Newborn screening for inborn errors of metabolism: a systematic review
No full textObjectives: to establish a database of literature and other evidence on neonatal screening programmes and technologies for inborn errors of metabolism. To undertake a systematic review of the data as a basis for evaluation of newborn screening for inborn errors of metabolism. To prepare an objective summary of the evidence on the appropriateness and need for various existing and possible neonatal screening programmes for inborn errors of metabolism in relation to the natural history of these diseases. To identify gaps in existing knowledge and make recommendations for required primary research. To make recommendations for the future development and organisation of neonatal screening for inborn errors of metabolism in the UK. How the research was conducted: there were three parts to the research. A systematic review of the literature on inborn errors of metabolism, neonatal screening programmes, new technologies for screening and economic factors. Inclusion and exclusion criteria were applied, and a working database of relevant papers was established. All selected papers were read by two or three experts and were critically appraised using a standard format. Seven criteria for a screening programme, based on the principles formulated by Wilson and Jungner (WHO, 1968), were used to summarise the evidence. These were as follows. Clinically and biochemically well-defined disorder. Known incidence in populations relevant to the UK. Disorder associated with significant morbidity or mortality. Effective treatment available. Period before onset during which intervention improves outcome. Ethical, safe, simple and robust screening test. Cost-effectiveness of screening. A questionnaire which was sent to all newborn screening laboratories in the UK. Site visits to assess new methodologies for newborn screening. The classical definition of an inborn error of metabolism was used (i.e., a monogenic disease resulting in deficient activity in a single enzyme in a pathway of intermediary metabolism). Research findings: inborn errors of metabolism. Phenylketonuria (PKU) (incidence 1:12,000) fulfilled all the screening criteria and could be used as the 'gold standard' against which to review other disorders despite significant variation in methodologies, sample collection and timing of screening and inadequacies in the infrastructure for notification and continued care of identified patients. Of the many disorders of organic acid and fatty acid metabolism, a case can only be made for the introduction of newborn screening for glutaric aciduria type 1 (GA1; estimated incidence 1:40,000) and medium-chain acyl CoA dehydrogenase (MCAD) deficiency (estimated incidence 1:8000-1:15,000). Therapeutic advances for GA1 offer prevention of neurological damage but further investigation is required into the costs and benefits of screening for this disorder. MCAD deficiency is simply and cheaply treatable, preventing possible early death and neurological handicap. Neonatal screening for these diseases is dependent upon the introduction of tandem mass spectrometry (tandem MS). This screening could however also simultaneously detect some other commonly-encountered disorders of organic acid metabolism with a collective incidence of 1:15,00
Comments on “Precipitation kinetics of Al–1.12Mg2Si–0.35Si and Al–1.07Mg2Si–0.33Cu alloys”
No full textIt is shown that in analysing DSC data of precipitation reactions in Al–1.12Mg2Si–0.35Si, Al–1.07Mg2Si–0.33Cu and Al–1.0Mg2Si–0.5Ag alloys in work by Gaber et al., accurate values for the activation energies are obtained by applying the method derived by the present author (the Type B-1.92 method). Values obtained from other analysis methods reported by Gaber et al. are less accurate. Averaging activation energies obtained by different methods introduces inaccuracies and obscures these inaccuracies, especially if the set of methods applied includes highly inaccurate ones, such as the Ozawa and Takhor methods
Optical Flow Based State Estimation for an Indoor Micro Aerial Vehicle
No full textThis work addresses the problem of indoor state estimation for autonomous flying vehicles with an optic flow approach. The paper discusses a sensor configuration using six optic flow sensors of the computer mouse type augmented by a three-axis accelerometer to estimate velocity, rotation, attitude and viewing distances. It is shown that the problem is locally observable for a moving vehicle. A Kalman filter is used to extract these states from the sensor data. The resulting approach is tested in a simulation environment evaluating the performance of three Kalman filter algorithms under various noise conditions. Finally, a prototype of the sensor hardware has been built and tested in a laboratory setup. Paper published: Verveld, M.J., Chu, Q.P., De Wagter, C. and Mulder, J.A. “Optic Flow Based State Estimation for an Indoor Micro Air Vehicle” AIAA Guidance, Navigation, and Control Conference, August 2010, Toronto, Canada AIAA 2010-8209, DOI: 10.2514/6.2010-8209Aerospace EngineeringControl & Simulatio
Transient time-averaged spectra of rapidly-modulated semiconductor lasers
No full textUsing the computed solution of multimode rate equations, and including wavelength-chirping effects via the dependence of the refractive index on carrier concentration, it is possible to calculate time-averaged spectra of rapidly-modulated lasers. The averaging time may be used to simulate the effects of measuring equipment with a specific time response. The results show a characteristic line structure within the dominant longitudinal mode spectrum, and are in qualitative agreement with experimental measurements reported by other author
Gift inscription in Minions of the Moon: a little book of song and story
No full textThis edition includes a gift inscription possibly penned by the author, Madison Julius Cawein, "Frank on Valentines Day, 1914. M.J." Madison Julius Cawein (1865-1914).Cawein, Madison Julius, 1865-1914
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