203,789 research outputs found
Immunohistochemical Investigations on External Auditory Canal Cholesteatomas
No full textAdamczyk M, Sudhoff H, Jahnke K. Immunohistochemical Investigations on External Auditory Canal Cholesteatomas. Otology & Neurotology. 2003;24(5):705-708
Neurobiology, Molecular Pathways, and Environmental Influences in Antisocial Traits and Personality Disorders.
No full textPersonality disorders (PDs) are psychiatric conditions characterized by enduring patterns of cognition, emotion, and behaviour that deviate significantly from cultural norms, causing distress or impairment. The aetiology of PDs is complex, involving both genetic and environmental factors. Genetic studies estimate the heritability of PDs at 30% to 60%, implicating genes involved in neurotransmitter regulation, such as those for serotonin transporters and dopamine receptors. Environmental factors, including childhood trauma and chronic stress, interact with genetic predispositions to induce epigenetic modifications like DNA methylation and histone modifications, contributing to PD development.
Neurobiological research has identified structural and functional abnormalities in brain regions related to emotional regulation and social cognition, such as the amygdala, prefrontal cortex, and limbic system. These abnormalities are linked to impaired emotion processing and interpersonal functioning in PDs. This review focuses on how environmental factors shape maladaptive behaviours and endophenotypes central to many PDs. It explores the interaction between the Ras-ERK, p38, and mTOR molecular pathways in response to environmental stimuli, and examines the role of oxidative stress and mitochondrial metabolism in these processes.
Also reviewed are various types of PDs and existing animal models that replicate key endophenotypes, highlighting changes in neurotransmitters and neurohormones. Identifying molecular biomarkers can lead to the development of "enviromimetic" drugs, which mimic environmental influences to activate molecular pathways, facilitating targeted, personalized treatments based on the molecular profiles of individuals with PDs. Ultimately, understanding the molecular mechanisms of PDs promises to enhance diagnostic accuracy, prognosis, and therapeutic outcomes for affected individuals
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
Młodzi a świat dorosłych w powieściach dla młodzieży Małgorzaty Gutowskiej-Adamczyk
No full textRecent juvenile fiction, like the popular literature, is much more connected with everyday life of young people than appreciated literary works of the past. In her juvenile novels, M. Gutowska-Adamczyk shows in an interesting way the relations between young people and their parents and grandparents (who are often closer to them than the parents, since they introduce them to unknown family secrets and are the keepers of tradition passed from one generation to another). The family identity built in such way is a fundament of such values as: respect, nobleness, devotion, indness, and the presence of the past in the present gives young people the awareness of one’s own “rootedness”. If these novels allow young people for deeper reflection on the surrounding world, for discourse with the characters and to experience authentic emotions, they will fulfill their task
Hardware-Efficient and Phase Noise Tolerant Digital Synchronous QPSK Receiver Concept
No full textHoffmann S, Pfau T, Adamczyk O, Peveling R, Porrmann M, Noe R. Hardware-Efficient and Phase Noise Tolerant Digital Synchronous QPSK Receiver Concept. In: Proceedings Optical Amplifiers and Their Applications/Coherent Optical Technologies and Applications. Optical Society of America; 2006.Simulation results and a first standard cell CMOS implementation are reported for efficient carrier and data recovery methods in the IF domain of digital I&Q receivers, for synchronous QPSK transmission with standard DFB lasers
sj-pdf-1-cep-10.1177_03331024211060315 - Supplemental material for Psychophysical testing in chronic migraine and chronic tension type headache: An observational study
No full textSupplemental material, sj-pdf-1-cep-10.1177_03331024211060315 for Psychophysical testing in chronic migraine and chronic tension type headache: An observational study by Ignacio Elizagaray-García, Gabriela F Carvalho, Tibor M Szikszay, Waclaw M Adamczyk, Gonzalo Navarro-Fernández, Paula Alvarez-Testillano, Javier Díaz-de-Terán, Kerstin Luedtke and Alfonso Gil-Martínez in Cephalalgia</p
Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses
No full textFollowing an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied
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