279 research outputs found
No i stało się. Szkic do manifestu gnostyka
No full textAnd So it Happened. A Draft of a Gnostic’s Manifesto The text by Janusz Jaroszewski the author of artistic and scientific book THAT THERE… with no name And so it happened is a draft of a manifesto, a critical assessment of all old and present religious as well as political doctrines, that are intersubjective imagined orders, which, in author’s assessment, currently led to very serious crisis of all kinds of values. Jaroszewski strengthens his diagnosis with references to writers, poets and philosophers, who also included these issues in their works – Thomas Bernhard, Yuval Noah Harari, Miguel de Unamuno and Marina Tsvetaeva. And So it Happened. A Draft of a Gnostic’s Manifesto The text by Janusz Jaroszewski the author of artistic and scientific book THAT THERE… with no name And so it happened is a draft of a manifesto, a critical assessment of all old and present religious as well as political doctrines, that are intersubjective imagined orders, which, in author’s assessment, currently led to very serious crisis of all kinds of values. Jaroszewski strengthens his diagnosis with references to writers, poets and philosophers, who also included these issues in their works – Thomas Bernhard, Yuval Noah Harari, Miguel de Unamuno and Marina Tsvetaeva
No i stało się. Szkic do manifestu gnostyka
No full textThe text by Janusz Jaroszewski (the author of artistic and scientific book THAT THERE... with no name) And so it happened is a draft of a manifesto, a critical assessment of all old and present religious as well as political doctrines, that are intersubjective imagined orders, which, in author’s as- sessment, currently led to very serious crisis of all kinds of values. Jaro- szewski strengthens his diagnosis with references to writers, poets and philosophers, who also included these issues in their works – Thomas Bernhard, Yuval Noah Harari, Miguel de Unamuno and Marina Tsvetaeva
Metropolita Jerzy (Jaroszewski) – biskup, intelektualista, człowiek
No full textMetropolita Jerzy (Jaroszewski) jest kluczową postacią w procesie nadania autokefalii Polskiemu Autokefalicznemu Kościołowi Prawosławnemu. Poza działalnością kościelną prowadził także działalność intelektualną. Był autorem artykułów teologicznych i filozoficznych, prac egzegetycznych i apologetycznych. Wiemy o nim jednak stosunkowo niewiele. Zazwyczaj w potocznym myśleniu jawi się nam jako hierarcha, który rozpoczął starania o autokefalię Kościoła prawosławnego w Polsce i który został zamordowany przez przeciwnika tej idei. W niniejszym artykule przedstawiona została syntetycznie ujęta biografia metropolity Jerzego oraz analiza jego wybranych prac naukowych.Metropolitan George (Yaroshevsky) is a key figure in the process of granting autocephaly to the Polish Autocephalous Orthodox Church. In addition to his church activities, he also conducted intellectual activities. He was the author of theological and philosophical articles, exegetical and apologetic works. However, we know relatively little about him. Usually, in common thinking, he appears to us as a hierarch who began efforts to obtain autocephaly and who was murdered for this decision by an opponent of the idea of autocephaly of the Orthodox Church in Poland. This article will provide a synthetic biography of Metropolitan George and an analysis of selected scientific works of this hierarch
FFAS03: a server for profile–profile sequence alignments
No full textThe FFAS03 server provides a web interface to the third generation of the profile-profile alignment and fold-recognition algorithm of fold and function assignment system (FFAS) [L. Rychlewski, L. Jaroszewski, W. Li and A. Godzik (2000), Protein Sci., 9, 232-241]. Profile-profile algorithms use information present in sequences of homologous proteins to amplify the patterns defining the family. As a result, they enable detection of remote homologies beyond the reach of other methods. FFAS, initially developed in 2000, is consistently one of the best ranked fold prediction methods in the CAFASP and LiveBench competitions. It is also used by several fold-recognition consensus methods and meta-servers. The FFAS03 server accepts a user supplied protein sequence and automatically generates a profile, which is then compared with several sets of sequence profiles of proteins from PDB, COG, PFAM and SCOP. The profile databases used by the server are automatically updated with the latest structural and sequence information. The server provides access to the alignment analysis, multiple alignment, and comparative modeling tools. Access to the server is open for both academic and commercial researchers. The FFAS03 server is available at http://ffas.burnham.org
Escaping an aversive context containing suicide-related information
No full textCase control study exploring the association between suicidal thoughts/behaviors and learning and decision-making in an aversive context in the presence of suicide-related information
Revealing aperiodic aspects of solenoid proteins from sequence information.
No full textMotivationRepeat proteins, which contain multiple repeats of short sequence motifs, form a large but seldom-studied group of proteins. Methods focusing on the analysis of 3D structures of such proteins identified many subtle effects in length distribution of individual motifs that are important for their functions. However, similar analysis was yet not applied to the vast majority of repeat proteins with unknown 3D structures, mostly because of the extreme diversity of the underlying motifs and the resulting difficulty to detect those.ResultsWe developed FAIT, a sequence-based algorithm for the precise assignment of individual repeats in repeat proteins and introduced a framework to classify and compare aperiodicity patterns for large protein families. FAIT extracts repeat positions by post-processing FFAS alignment matrices with image processing methods. On examples of proteins with Leucine Rich Repeat (LRR) domains and other solenoids like proteins, we show that the automated analysis with FAIT correctly identifies exact lengths of individual repeats based entirely on sequence information.Availability and implementationhttps://github.com/GodzikLab/FAIT CONTACT: [email protected] informationSupplementary data are available at Bioinformatics online
Discipline and Charity: John Milton\u27s Christian Virtue As Self-Completion
No full textJohn Milton attempted to depict in his epic, Paradise Lost, the story of Adam and Eve. He chose this topic because he understood the mythic significance for human beings of the need for a paradise which they know, and in which they participate, and always, in one way or another, relinquish. This circumstance of existence represents Adam and Eve\u27s predicament which Milton was attempting to portray because it mirrors the profound moral rhythm of life, beginning in idyllic innocence, evolving into moral conflict and temptation, and, ideally, being resolved in mature insight and righteousness. Milton lived in a time of great social, political and moral change: 1608-1674. He participated in, joined forces with, weathered and withdrew from the circumstances of the Puritan Revolution. The establishment of the Commonwealth of Cromwell, and later its failure, with the Restoration of Charles II, is part of his intellectual and emotional development. Disillusionment with public activity led him consequently to a serious focus on his personal situation. He attempted to evaluate his circumstances according to the beliefs he held which had been altered by experience. All variables are meaningful only insofar as they survive the crucible of his poetic honesty and devotion to his faith in God. More specifically, as he matured, the nature of his artistic mission became more subtle and individual, less wildly rebellious, more intellectually and spiritually radical. Throughout his lifetime his activities had involved his own personal struggles with his innate gifts and talents, and the implications of these. His initial academic pursuits, his subsequent individual life circumstances, involving his perception of himself as aspiring poet and revolutionary intellectual, led him to a personal knowledge and belief in the need for an appropriate use of the intellect and emotions. Milton presents the belief in his epic poem, Paradise Lost, that there exist two traits which humans require in order to achieve self-knowledge, or a regained paradise within. These attributes are discipline and charity. Many critics have presented these two characteristics as central to Milton\u27s writing, but they have not demonstrated, as I wish to, that their conjunction, if appropriately mastered and enacted, affords the individual possession of the paramount endowment of existence: Christian virtue. The health and strength of the intellect and emotions make this successful unity possible. Milton utilizes the human myth of the story of Adam and Eve in the Garden of Eden as the means to explain how their improperly moderated discipline and charity are the cause of their fall from grace. In the pre-lapsarian state they are morally similar to children and thus they are susceptible to temptation. The feelings of shame and despair they experience following their fall are part of the natural cycle of movement from ignorance to adult consciousness. The resonance of the Edenic myth consists in the depiction of Adam and Eve as prototypes of male and female beings whose success at the close of Paradise Lost represents the hope for redemption which all humanity shares. As a premier poet, Milton coaxes an attentive reader to discern the manner in which stereotypical patterns of male/female interaction prevent the creation of an emotionally indissoluble bond between two human beings. The portrayal of Adam and Eve touches most seriously on the spiritual saga they undergo, and from which they emerge. Milton believed in the supreme necessity and beauty of the bond between man and woman, which is the basis of personal and social stability and happiness
FFAS server: novel features and applications
No full textThe Fold and Function Assignment System (FFAS) server [Jaroszewski et al. (2005) FFAS03: a server for profile-profile sequence alignments. Nucleic Acids Research, 33, W284-W288] implements the algorithm for protein profile-profile alignment introduced originally in [Rychlewski et al. (2000) Comparison of sequence profiles. Strategies for structural predictions using sequence information. Protein Science: a Publication of the Protein Society, 9, 232-241]. Here, we present updates, changes and novel functionality added to the server since 2005 and discuss its new applications. The sequence database used to calculate sequence profiles was enriched by adding sets of publicly available metagenomic sequences. The profile of a user's protein can now be compared with ∼20 additional profile databases, including several complete proteomes, human proteins involved in genetic diseases and a database of microbial virulence factors. A newly developed interface uses a system of tabs, allowing the user to navigate multiple results pages, and also includes novel functionality, such as a dotplot graph viewer, modeling tools, an improved 3D alignment viewer and links to the database of structural similarities. The FFAS server was also optimized for speed: running times were reduced by an order of magnitude. The FFAS server, http://ffas.godziklab.org, has no log-in requirement, albeit there is an option to register and store results in individual, password-protected directories. Source code and Linux executables for the FFAS program are available for download from the FFAS server
Decision-making under Risk and Ambiguity in People With OCD: The Role of Intolerance of Uncertainty
No full textThis is an analysis of the Risk and Ambiguity Task (Levy et al., 2010) from a dataset originally published by senior author Dr. Ryan J. Jacoby in 2023 (see original pre-registration at https://clinicaltrials.gov/study/NCT03420495?cond=OCD&term=jacoby&rank=1). Here, we compare performance on the R & A task between people with OCD and non-psychiatric controls (NPCs) and examine the relationship between task performance and a number of self-report variables (e.g. intolerance of uncertainty, decision-making styles, OCD symptom severity)
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Examining Affect and Decision-Making in Relation to Suicide
No full textSuicide is one of the most tragic, costly, and perplexing of all human behaviors. Despite millennia of scholarly inquiry and a century of empirical research, we still do not know why people kill themselves. Thus, suicide remains a leading cause of death and burden. Ultimately, each person who attempts or dies by suicide must first make the decision to take their own life, meaning that they must select suicide over alternative options. One reason some people might select suicide is that they view suicide as a relatively good option for escaping extremely aversive contexts. One way to understand how people view an option’s goodness is to assess their affect toward it. In this dissertation I examined whether affect toward suicide differs between people with and without recent suicidal thoughts and behaviors (STB) and whether suicide information influences decision-making in an aversive context.
In Study 1, we developed and evaluated a set of self-relevant suicide pictures depicting suicidal behavior from the participant’s own perspective in order to more validly assess affect and decision-making in relation suicide. Next, we examined explicit affect to these suicide pictures among people with and without STB. Study 1 findings suggest that the suicide pictures we developed are valid and reliable and, as hypothesized, people with STB find these pictures substantially more pleasant/less aversive than people without STB. In study 2, we examined implicit affect toward the suicide pictures among both adults and adolescents with and without STB. Study 2 findings suggest that implicit affect toward suicide is related to STB history; however, contrary to our hypothesis, suicidal participants did not display higher implicit positive affect toward suicide stimuli than nonsuicidal people. In study 3, we used the suicide pictures as cues in a decision-making task among people with and without STB, and we explored whether a computational model could capture latent decision-making biases within task behavior. Study 3 findings suggest that suicide pictures lead to poorer decision-making among suicidal, but not nonsuicidal, people when making decisions to escape an aversive context. Also, the computational model captured a decision-making bias related to the suicide pictures that helped distinguish suicidal from nonsuicidal participants over and above other strong predictors.
Together, these findings suggest that suicidal people view and make decisions in relation to suicide differently than nonsuicidal people. Future studies, particularly those using longitudinal designs, are needed to better understand the directionality of these relationships and determine whether affect toward suicide predicts future STB. Better understanding the decision-making processes driving some people to select suicide could shed light on what we can do to help people select alternative options and, thereby, prevent suicide
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