797 research outputs found
Allgemeine Geschichte der Welt und Natur, der Völker, der Staaten, der Kirche, der Wissenschaften und Künste : Aus den Quellen selbst geschöpft / [Adam Wilhelm Franzen, Johann Christoph Adelung]
No full textIn FrakturLaut WBIS online, GK, Kayser: Teil 1 verfasst von Adam Wilhelm Franzen und Teil 2 von Johann Christoph AdelungVorlageform der Veröffentlichungsangabe: Berlin, ... Bey Christian Friedrich Voß
An exploration of knowledge type and firm performance: A study in the MLB
No full textThere is both theoretical and empirical support for the idea that firm-specific knowledge (FSK) has a greater effect on sustained competitive advantage than general knowledge (GK). However, empirical support suffers from several practical and methodological challenges which suggest that the relationships between FSK, GK, and firm performance are even more nuanced than previously considered. Multilevel modeling techniques (polynomial regression and latent growth modeling) were implemented to test these effects on both short- and long-term performance among MLB teams between 2015-2019. Although the results of the hypothesis tests and post-hoc analyses were largely non-significant, they do provide some information that furthers the research on the resource-based view of the firm (RBV). More specifically, they suggest that both an FSK- and GK-focused approach may create short-term performance advantages for firms, and that firms experiencing the “low/low” condition – low GK and low FSK – may experience consistently low performance as a result. A future research agenda associated with these topics is proposed
NEUERSCHEINUNG: ‘‘The Age of Louis XIV‘‘: Frederick the Great and French Ways of War – Adam L. Storring
No full textJohann Georg Ziesenis: Friedrich der Große, um 1763, Copyright: SPSG, GK I 1216, Foto: Wolfgang Pfauder Dr Adam Storring’s article ‘‘The Age of Louis XIV‘‘: Frederick the Great and French Ways of War, published in German History, demonstrates that the military ideas of King Frederick the Great of Prussia up to the Seven Years War (1756–1763) were primarily inspired by France, and particularly by the towering figure of King Louis XIV. It examines the intellectual inspirations for Frederick’s m..
The onset of large-scale turbulence in the interstellar medium of spiral galaxies
No full textDFG thanks the European Research Council (ADG-2011 ECOGAL), and Brazilian agencies CAPES (3400-13-1) and FAPESP (no.2011/12909-8) for financial support. IB acknowledges the European Research Council (ADG-2011 ECOGAL) for financial support. GK acknowledges support from FAPESP (grants no. 2013/04073-2 and 2013/18815-0).Turbulence is ubiquitous in the interstellar medium (ISM) of the Milky Way and other spiral galaxies. The energy source for this turbulence has been much debated with many possible origins proposed. The universality of turbulence, its reported large-scale driving, and that it occurs also in starless molecular clouds, challenges models invoking any stellar source. A more general process is needed to explain the observations. In this work, we study the role of galactic spiral arms. This is accomplished by means of three-dimensional hydrodynamical simulations which follow the dynamical evolution of interstellar diffuse clouds (similar to 100 cm-3) interacting with the gravitational potential field of the spiral pattern. We find that the tidal effects of the arm's potential on the cloud result in internal vorticity, fragmentation and hydrodynamical instabilities. The triggered turbulence results in large-scale driving, on sizes of the ISM inhomogeneities, i.e. as large as similar to 100 pc, and efficiencies in converting potential energy into turbulence in the range similar to 10-25 per cent per arm crossing. This efficiency is much higher than those found in previous models. The statistics of the turbulence in our simulations are strikingly similar to the observed power spectrum and Larson scaling relations of molecular clouds and the general ISM. The dependence found from different models indicate that the ISM turbulence is mainly related to local spiral arm properties, such as its mass density and width. This correlation seems in agreement with recent high angular resolution observations of spiral galaxies, e.g. M51 and M33.Peer reviewe
Experimental studies on isolated supersonic air-intake models of a typical air-breathing launch vehicle
No full textThe performance of two supersonic air-intake configurations, S1 and S2, has been extensively analyzed through qualitative and quantitative measurements at Mach numbers in the range 1.8 to 3.0. The exit area of the intake was varied during the tests using a butterfly valve, which was controlled using a PC. The performance of S2 was found to be comparable with that of a standard supersonic intake, with characteristic features of supercritical and subcritical behavior, whereas S1 configuration did not indicate any critical condition. The critical condition for S2 was found to occur when the exit area was about 1.24 times the throat area at M = 3.0. The measured total pressure recovery with S2 was found to be marginally higher than that for S1, whereas the mass flow rate through the intake showed considerable improvement (e.g., 11 percent at M = 3.0 and 19 percent at M = 2.0 at maximum pressure recovery condition). Similar improvements were found with the S2 configuration at other Mach numbers also. It is proposed that an Intake Performance Index (product of the pressure recovery and mass flow efficiencies), as a function of the back-pressure, may be used to compare the efficiencies of different intake configurations. (Author
PRECISION MEASUREMENT OF THE IONIZATION ENERGY OF THE STATE OF MOLECULAR HYDROGEN.
No full textAuthor Institution: ETH Zurich, Laboratorium fur Physikalische Chemie, Wolfgang-Pauli-Strasse 10, 8093 Zurich, SwitzerlandThe ionization energy of the state of ortho H has been determined at a precision of 1.2~MHz by near-infrared laser spectroscopy. The measurement was performed by first exciting molecular hydrogen from the state to the state in a resonant two-photon process via the state and then measuring the frequency of the transition between the state and the 56p~ Rydberg state belonging to the series converging on the ground state of ortho H. The ionization energy of the state was obtained by adding this frequency to the binding energy of the 56p~ Rydberg state which has been determined previously by millimeter-wave spectroscopy and multichannel quantum-defect theory \textbf{121} (23), 11810 (2004).} \textbf{150}, 51 (2011).}. For the measurement we used a homebuilt pulsed NIR laser with Fourier-transform-limited linewidth and adjustable pulse duration. To reach the desired accuracy, systematic errors originating from ac and dc Stark shifts, from pressure shifts, and from the frequency shifts and chirps accompanying the generation of the NIR laser pulses were quantified. The ionization energy of the state will be compared with earlier results \textbf{93} (4), 2289 (1990).} \textbf{108} (7-9), 827 (2010).}. New attempts of measuring the binding energy of the state will also be mentioned
Identification and Visualization of Functionally Important Domains and Residues in Herpes Simplex Virus Glycoprotein K(gK) Using a Combination of Phylogenetics and Protein Modeling
No full text© 2019, The Author(s). Alphaherpesviruses are a subfamily of herpesviruses that include the significant human pathogens herpes simplex viruses (HSV) and varicella zoster virus (VZV). Glycoprotein K (gK), conserved in all alphaherpesviruses, is a multi-membrane spanning virion glycoprotein essential for virus entry into neuronal axons, virion assembly, and pathogenesis. Despite these critical functions, little is known about which gK domains and residues are most important for maintaining these functions across all alphaherpesviruses. Herein, we employed phylogenetic and structural analyses including the use of a novel model for evolutionary rate variation across residues to predict conserved gK functional domains. We found marked heterogeneity in the evolutionary rate at the level of both individual residues and domains, presumably as a result of varying selective constraints. To clarify the potential role of conserved sequence features, we predicted the structures of several gK orthologs. Congruent with our phylogenetic analysis, slowly evolving residues were identified at potentially structurally significant positions across domains. We found that using a quantitative measure of amino acid rate variation combined with molecular modeling we were able to identify amino acids predicted to be critical for gK protein structure/function. This analysis yields targets for the design of anti-herpesvirus therapeutic strategies across all alphaherpesvirus species that would be absent from more traditional analyses of conservation
On Type IIA AdS3 solutions and massive GK geometries
No full textWe give necessary and sufficient conditions for warped AdS3 (and Mink3) solutions of Type II supergravities to preserve N= (2, 0) supersymmetry, in terms of geometric conditions on their internal space M7. Such solutions possess a canonical ten-dimensional Killing vector that can be either time-like or null. In this work we classify the null case in massive Type IIA supergravity which necessitates that M7 decomposes as a circle fibration over a six-dimensional base with orthogonal SU(2)-structure containing a complex four-manifold. We narrow our focus to solutions for which M7 becomes T2 fibred over a foliation of a Kähler manifold over an interval. We find a class of solutions which are the massive Type IIA version of GK geometries and present an extremal problem which computes the central charge of the solution using just topology. Finally, we present geometric conditions for AdS3 solutions to preserve arbitrary extended chiral supersymmetry. © 2022, The Author(s)
Prevalence and Factors Associated with Adherence to Iron-Folic Acid Supplementation Among Pregnant Women in Eastern Sudan: A Cross-Sectional Study
No full textMustafa S Saeed,1 Gamal K Adam,2 Samah M Hussein,1 Nadiah AlHabardi,3 Ishag Adam3 1Department of Pharmacy Practice, College of Pharmacy, Qassim University, Buraidah, Qassim, 51452, Saudi Arabia; 2Faculty of Medicine, Gadarif University, Gadarif, Sudan; 3Department of Obstetrics and Gynecology, College of Medicine, Qassim University, Buraidah, Saudi ArabiaCorrespondence: Gamal K Adam, Department of Obstetrics and Gynecology, Faculty of Medicine, Gadarif University, Gadarif, 32211, Sudan, Email [email protected]: The present study was conducted to determine the prevalence and factors associated with adherence to iron-folic acid supplementation (IFAS) among pregnant women in eastern Sudan.Methods: A cross-sectional survey was conducted among pregnant women who obtained antenatal care (ANC) at Gadarif Maternal Hospital in eastern Sudan between May 1 and August 31, 2023. Face-to-face interview questionnaires were used to gather sociodemographic, obstetric, and clinical data (age, parity, education, residence, and previous medical diseases). Knowledge of anemia and IFAS was assessed. Multivariate analysis was performed to adjust for confounders.Results: A total of 568 pregnant women were enrolled in the present study. Among them, 449 (79.0%) adhered to the IFAS. The multivariate analysis showed that the adjusted odds ratio (AOR) of IFAS adherence increased with ANC visits > 4 (AOR = 1.68, 95.0% CI = 1.01– 2.77) and knowledge of anemia (AOR = 2.06, 95.0% CI = 1.437– 3.276). In the univariate analysis, maternal occupation and knowledge of IFAS adherence were the only factors associated with IFAS adherence. Maternal age, parity, gestational age, education, residence, occupation, medical insurance, medical disease, and husband’s occupation were not associated with IFAS. Forgetfulness (71.0%), frustration from taking many drugs (54.6%), and unpleasant tests of the supplement (50.7%) were the main reasons for not taking the IFAS.Conclusion: About four out of five pregnant women adhered to the IFAS, indicating a good level of adherence, especially among women who attended more than four ANC visits and those with good knowledge of anemia. More attention is needed to encourage ANC to increase adherence to IFAS.Keywords: iron, folic acid, pregnancy, age, adherenc
Safety of Artemether-Lumefantrine Exposure in First Trimester of Pregnancy: An Observational Cohort.
No full textThere is limited data available regarding safety profile of artemisinins in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated embryo-foetal toxicity in animal studies. The study assessed birth outcome among pregnant women inadvertently exposed to artemether-lumefantrine (AL) during first trimester in comparison to those of women exposed to other anti-malarial drugs or no drug at all during the same period of pregnancy. Pregnant women with gestational age <20 weeks were recruited from Maternal Health clinics or from monthly house visits (demographic surveillance), and followed prospectively until delivery. 2167 pregnant women were recruited and 1783 (82.3%) completed the study until delivery. 319 (17.9%) used anti-malarials in first trimester, of whom 172 (53.9%) used (AL), 78 (24.4%) quinine, 66 (20.7%) sulphadoxine-pyrimethamine (SP) and 11 (3.4%) amodiaquine. Quinine exposure in first trimester was associated with an increased risk of miscarriage/stillbirth (OR 2.5; 1.3-5.1) and premature birth (OR 2.6; 1.3-5.3) as opposed to AL with (OR 1.4; 0.8-2.5) for miscarriage/stillbirth and (OR 0.9; 0.5-1.8) for preterm birth. Congenital anomalies were identified in 4 exposure groups namely AL only (1/164[0.6%]), quinine only (1/70[1.4%]), SP (2/66[3.0%]), and non-anti-malarial exposure group (19/1464[1.3%]). Exposure to AL in first trimester was more common than to any other anti-malarial drugs. Quinine exposure was associated with adverse pregnancy outcomes which was not the case following other anti-malarial intake. Since AL and quinine were used according to their availability rather than to disease severity, it is likely that the effect observed was related to the drug and not to the disease itself. Even with this caveat, a change of policy from quinine to AL for the treatment of uncomplicated malaria during the whole pregnancy period could be already envisaged.\u
- …
