3,359 research outputs found
Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery
No full textCopyright @ 2014 Booth et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.When the nucleolus disassembles during open mitosis, many nucleolar proteins and RNAs associate with chromosomes, establishing a perichromosomal compartment coating the chromosome periphery. At present nothing is known about the function of this poorly characterised compartment. In this study, we report that the nucleolar protein Ki-67 is required for the assembly of the perichromosomal compartment in human cells. Ki-67 is a cell-cycle regulated protein phosphatase 1-binding protein that is involved in phospho-regulation of the nucleolar protein B23/nucleophosmin. Following siRNA depletion of Ki-67, NIFK, B23, nucleolin, and four novel chromosome periphery proteins all fail to associate with the periphery of human chromosomes. Correlative light and electron microscopy (CLEM) images suggest a near-complete loss of the entire perichromosomal compartment. Mitotic chromosome condensation and intrinsic structure appear normal in the absence of the perichromosomal compartment but significant differences in nucleolar reassembly and nuclear organisation are observed in post-mitotic cells
Inertia emulation control of VSC-HVDC transmission system
No full textThe increasing penetration of power electronics interfaced renewable generation (e.g. offshore wind) has been leading to a reduction in conventional synchronous-machine based generation. Most converter-interfaced energy sources do not contribute to the overall power system inertia; and therefore cannot support the system during system transients and disturbances. It is therefore desirable that voltage-source-converter (VSC) based high voltage direct current (HVDC) interfaces, which play an important role in delivery of renewable power to AC systems, could contribute a virtual inertia and provide AC grid frequency support. In this paper, an inertia emulation control (IEC) system is proposed that allows VSC-HVDC system to perform an inertial response in a similar fashion to synchronous machines (SM), by exercising the electro-static energy stored in DC shunt capacitors of the HVDC system. The proposed IEC scheme has been implemented in simulations and its performance is evaluated using Matlab/Simulink
AUT894824_Lay_Abstract – Supplemental material for Reliability and validity of teacher ratings on the Adapted Skillstreaming Checklist for children with autism spectrum disorder
No full textSupplemental material, AUT894824_Lay_Abstract for Reliability and validity of teacher ratings on the Adapted Skillstreaming Checklist for children with autism spectrum disorder by Christopher Lopata, James P Donnelly, Jonathan D Rodgers, Marcus L Thomeer and Adam J Booth in Autism</p
Andrew D. Booth – Britain’s Other “Fourth Man”
No full textInternational audienceAndrew Donald Booth (1918-2009) was the leader of a team of computer pioneers at Birkbeck College in the University of London, UK. Booth worked with limited resources, both human and financial, and concentrated on building smaller machines. This paper presents an outline of his career in the UK which, the author believes, has not received the attention it deserves in comparison to a number of his UK contemporaries
AUT868639_Lay_Abstract – Supplemental material for Exploratory factor analysis of the Adapted Skillstreaming Checklist for children with autism spectrum disorder
No full textSupplemental material, AUT868639_Lay_Abstract for Exploratory factor analysis of the Adapted Skillstreaming Checklist for children with autism spectrum disorder by Christopher Lopata, James P Donnelly, Marcus L Thomeer, Jonathan D Rodgers, Martin A Volker and Adam J Booth in Autism</p
#947 The Speaker's Role: Origin and Extent.
No full textParticipants include: Ron. Richard Bolling, Member of Congress (D) from Missouri and author of House Out of Order Mr. Booth Mooney, Author of Mr. Speaker Dr. Stephen Gilbert, Assoc. Professor of Government, Georgetown Universit
Quantitative analysis of faulting in the Danakil Depression Rift of Afar: the importance of faulting in the final stages of magma-rich rifting
No full textMagmatic intrusion and faulting both accommodate crustal extension in magma-rich rifts. However, quantitative constraints on the contribution of faulting to total extension and along-rift variations of faulting during the final stages of break-up are lacking. We targeted the Danakil Depression (Afar, Ethiopia) to conduct a quantitative, high-resolution study of fault activity and interaction in a magma-rich rift near break-up. Quantitative analysis of >500 rift axis faults, identified using remote sensing data (satellite imagery, DEMs), shows an increase in fault density, length and connectivity away from magmatic segments. Kinematic and earthquake focal mechanism data demonstrate a transition from transtensional opening in the northern and central sub-regions of the rift to oblique opening in the southern Giulietti Plain and Tat-Ali sub-regions. Oblique opening is attributed to the along-axis step between the Erta-Ale and Harak sub-regions. Integration of seismic reflection and borehole data with the mapped faults shows that extension is primarily accommodated by magmatism within the rift center, with faulting more significant towards the ends of the rift. ∼30% of crustal extension is accommodated by axial faulting in areas of low magmatism, highlighting the importance of faulting even in the final stages of magma-rich rifting. Comparing our findings with spreading ridge morphology and structure, relevant due to the rift maturity and extensive magmatism, we conclude that the Danakil Depression is in a transitional stage between continental rifting and seafloor spreading. Spatial changes in the importance of faulting and magmatism in accommodating extension, alongside rift morphology, resemble the relationships observed along spreading ridges
The construction of Karen Karnak: The multi-author-function
No full textThis thesis is situated within the comparatively recent developments of Web 2.0 and the emergence of interactive WikiMedia, and explores the mode of authorship within a Read/Write culture compared to that of a Read/Only tradition. The hypothesis of this study is that the role of the audience has become merged with the author, and as such, represents new functions and attributes, distinct from a more conventional concept of authorship, in which the roles of audience and author are more separate. Read/Write and participatory culture, as defined by this study, is focused on collaboration, and includes the influences of D.I.Y. culture, Open-Source practices and the production of text by multiple authors. Multi-authorship presents a re-thinking of several concepts which support the notion of the individual author, since the focus of multi-authorship is not on attribution and ownership of a finished text, but on the continued malleability of a text. Modes of multi-authorship, demonstrated in the use of the pseudonyms Alan Smithee and Karen Eliot, represent declarative authors whose names signify multiple origins, whilst concurrently indicating a distinct body of work. The function of these names form an important context to this study, since primary research involves the construction of an experimental mode of multi-authorship utilising WikiMedia technology and the interaction of thirty nine participants, who are invited to create a body of work under the collective pseudonym Karen Karnak. The data generated by this experiment is analysed using aspects of Michel Foucault's author-function to identify and determine power structures inherent in the WikiMedia context. The interplay of power structures, including concepts such as identity, ownership and the body of work, affect the resulting mode of authorship and contribute to the construction of Karen Karnak, suggesting further areas of research into the emerging multi-author
Beyond Lesson Studies and Design Experiments: Using theoretical tools in practice and finding out how they work
No full textThis paper aims to illustrate how fruitful insights into the link between school teaching practice and student learning outcomes can be theoretically grounded by the variation theory from the field of phenomenography; and from this framework demonstrate how a 'pedagogy of awareness' can be implemented in the classroom. In this study, five teachers and 162 students at Primary Four level of school education in Hong Kong participated and the practice of the 'learning study' was adopted. By comparing the results of pre- and posttests, a significant gain was observed in the students learning outcomes.
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