57 research outputs found
L’information dans le domaine de la santé sur INTERNET
No full textL’auteur propose un survol des ressources du réseau Internet dans le domaine de la santé. Il offre un aperçu des deux modes de diffusion disponibles, les « listservs » ou listes de distribution et les « newsgroups » ou forums de discussion. Il décrit brièvement les logiciels d’accès et de navigation et, à l’aide d’exemples, identifie des sources d’information médicale.The author surveys health-related information available on INTERNET. Information is shared and exchanged on Listservs and Newsgroups. He also describes the software used to sign-on and to navigate on INTERNET and, with the help of several examples, he identifies the sources of medical information.El autor propone un resumen de los recursos de la red internet en el campo de la salud. Ofrece un resumen de los dos modos de difusión disponibles, los "listservs" o listas de distribución y los "newsgroups" o forums de discusión. Describe brevemente los programas de acceso y de navegación y, con la ayuda de ejemplos, identifica las fuentes de información médica
The Naval Postgraduate School’s Small Robotics Technology Initiative: Initial Platform Integration and Testing 6. AUTHOR(S)
No full textPublic reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instruction, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washingto
Acute fasting regulates retrograde synaptic enhancement through a 4E-BP-dependent mechanism
No full textWhile beneficial effects of fasting on organismal function and health are well appreciated, we know little about the molecular details of how fasting influences synaptic function and plasticity. Our genetic and electrophysiological experiments demonstrate that acute fasting blocks retrograde synaptic enhancement that is normally triggered as a result of reduction in postsynaptic receptor function at the Drosophila larval neuromuscular junction (NMJ). This negative regulation critically depends on transcriptional enhancement of eukaryotic initiation factor 4E binding protein (4E-BP) under the control of the transcription factor Forkhead box O (Foxo). Furthermore, our findings indicate that postsynaptic 4E-BP exerts a constitutive negative input, which is counteracted by a positive regulatory input from the Target of Rapamycin (TOR). This combinatorial retrograde signaling plays a key role in regulating synaptic strength. Our results provide a mechanistic insight into how cellular stress and nutritional scarcity could acutely influence synaptic homeostasis and functional stability in neural circuits
Efficiency Measurement in the Local Public Sector: Econometric and Mathematical Programming Frontier Techniques
No full textLocal government in advanced economies is undergoing a period of rapid reform aimed at enhancing its efficiency and effectiveness. Accordingly, the definition, measurement and improvement of organisational performance is crucial. Despite the importance of efficiency measurement in local government it is only relatively recently that econometric and mathematical frontier techniques have been applied to local public services. This paper attempts to provide a synoptic survey of the comparatively few empirical analyses of efficiency measurement in local government. We examine both the measurement of inefficiency in local public services and the determinants of local public sector efficiency. The implications of efficiency measurement for practitioners in local government are examined by way of conclusion.
Journal of the National Collegiate Honors Council, Volume 16, Number 2, Fall/Winter 2015 (complete issue)
No full text50th Anniversary Issue
Forum on the Value of Honors
with essays by James Herbert and by 39 college and university presidents:
Paul W. Ferguson, President of Ball State University; Honors Dean: James S. Ruebel
J. David Armstrong, Jr., President of Broward College; Honors Director: Sheila Jones
Soraya M. Coley, President of Cal Poly Pomona; Honors Director: Suketu P. Bhavsar
Elizabeth A. Dinndorf, President of Columbia College; Honors Director: John Zubizarreta
Quintin B. Bullock, President of Community College of Allegheny County; Honors Director: Julia Fennell
Michael T. Benson, President of Eastern Kentucky University; Interim Honors Director: David Coleman
Jake B. Schrum, President of Emory & Henry College; Honors Director: Joe Lane
Mark P. Becker, President of Georgia State University; Honors Dean: Larry Berman
Thomas J. Haas, President of Grand Valley State University; Honors Director: Jeff Chamberlain
Jerry Corcoran, President of Illinois Valley Community College; Honors Director: Adam Oldaker
Joseph E. Nyre, President of Iona College; Honors Director: Kim Paffenroth
Jonathan Alger, President of James Madison University; Honors Director: Bradley Newcomer
Gail O. Mellow, President of LaGuardia Community College/CUNY; Honors Director: Karlyn Koh
Kimberly R. Cline, President of LIU; Honors Director: Joan Digby, LIU Post; Honors Director: James P. Clarke, LIU Brooklyn
Kevin Wm. Wildes, President of Loyola University New Orleans; Honors Director: Naomi Yavneh Klos
Stephen J. Jerome, President of Monroe College; Honors Coordinator: Kathryn M. MacDonald
Harold L. Martin, Sr., Chancellor of North Carolina A&T State University; Honors Director: Michael K. Cundall, Jr.
Geoffrey S. Mearns, President of Northern Kentucky University; Interim Honors Director: Belle Zembrodt
George L. Hanbury II, President of Nova Southeastern University; Honors Dean: Don Rosenblum
William M. Wilson, President of Oral Roberts University; Honors Director: John Korstad
Dennis R. Harkins, President of Orange Coast College; Honors Coordinator: Karen Baker
Larry Rice, President of Rogers State University; Honors Director: Jim Ford
Ron Bormans, President of Rotterdam University of Applied Sciences (the Netherlands); Honors Dean: Ron Weerheijm
Tashni-Ann Dubroy, President of Shaw University; Honors Director: Kim Q. B. Leathers
David L. Chicoine, President of South Dakota State University; Honors Director: Timothy J. Nichols
Sean Burrage, President of Southeastern Oklahoma State University; Honors Director: Lisa L. Coleman
Baker Pattillo, President of Stephen F. Austin State University; Honors Director: Michael Tkacik
Dan R. Jones, President of Texas A&M University – Commerce; Honors Dean: Raymond J. Green
James R. Johnsen, President of University of Alaska; Interim Honors Dean: John Mouracade (Anchorage); Honors Coordinator: Sol Neely (Southeast); Honors Director: Marsha Sousa (Fairbanks)
Susan J. Koch, Chancellor of University of Illinois at Springfield; Honors Director: Marc Klingshirn
Marc A. Johnson, President of University of Nevada, Reno; Honors Director: Tamara M. Valentine
Bonita C. Jacobs, President of University of North Georgia; Honors Director: Stephen Smith
Mark A. Heckler, President of Valparaiso University; Honors Dean: Peter Kanelos
Michael Rao, President of Virginia Commonwealth University; Honors Dean: Barry Falk
M. Roy Wilson, President of Wayne State University; Honors Dean: Jerry Herron
E. Gordon Gee, President of West Virginia University; Honors Dean: Kenneth P. Blemings
Gary A. Ransdell, President of Western Kentucky University; Honors Director: Craig T. Cobane
Steve Morgan, President of Westminster College; Honors Director: Richard Badenhausen
Albert Cornelissen, President of Windesheim University of Applied Sciences (the Netherlands); Honors Dean: Josephine Woltman Elper
Ets-1 Maintains IL-7 Receptor Expression in Peripheral T Cells
No full textAbstract
The expression of CD127, the IL-7–binding subunit of the IL-7 R, is tightly regulated during the development and activation of T cells and is reduced during chronic viral infection. However, the molecular mechanism regulating the dynamic expression of CD127 is still poorly understood. In this study, we report that the transcription factor Ets-1 is required for maintaining the expression of CD127 in murine peripheral T cells. Ets-1 binds to and activates the CD127 promoter, and its absence leads to reduced CD127 expression, attenuated IL-7 signaling, and impaired IL-7–dependent homeostatic proliferation of T cells. The expression of CD127 and Ets-1 is strongly correlated in human T cells. Both CD127 and Ets-1 expression are decreased in CD8+ T cells during HIV infection. In addition, HIV-associated loss of CD127 is only observed in Ets-1low effector memory and central memory but not in Ets-1high naive CD8+ T cells. Taken together, our data identify Ets-1 as a critical regulator of CD127 expression in T cells.</jats:p
Internal dose escalation is associated with increased local control for non-small cell lung cancer (NSCLC) brain metastases treated with stereotactic radiosurgery (SRS)
No full textHow do people with learning disabilities experience and make sense of the ageing process?
No full textNot enough is currently known about how people with learning disabilities experience and understand the ageing process. This is particularly important as the population of older people with learning disabilities is growing due to increased life expectancy. This study aims to fill this gap in the literature by exploring how people with learning disabilities experience and make sense of the ageing process and old age.
Seven people with learning disabilities aged 60 or over were interviewed, and their accounts were analysed using Interpretative Phenomenological Analysis. An individual analysis of each participant’s account is presented, followed by the group analysis. The master themes arising from the group analysis were: quality of relationships is central to enjoyment of life, including sub-themes on the importance of affection and companionship, distress at lack of closeness, and anxiety about ability to satisfy others; powerlessness; needing a sense of purpose; and making sense of getting older, including sub-themes on reactions to changes with age, life review and looking to the future.
The findings of the study are discussed in relation to the existing literature. Clinical implications of the findings include the need for services to support older people with learning disabilities in maintaining friendships and meaningful activities. This study demonstrates that some older people with learning disabilities can engage in a process of life review and learning disability services could play a useful role in facilitating this process. Understanding of the ageing process varied between participants, and tended towards a negative, stereotypical view of ageing. The findings suggest that people with learning disabilities could benefit from psychoeducation on the ageing process to aid them in making sense of the changes they experience as they get older
Image_6_Distinct Injury Responsive Regulatory T Cells Identified by Multi-Dimensional Phenotyping.tif
No full textCD4+ regulatory T cells (Tregs) activate and expand in response to different types of injuries, suggesting that they play a critical role in controlling the immune response to tissue and cell damage. This project used multi-dimensional profiling techniques to comprehensively characterize injury responsive Tregs in mice. We show that CD44high Tregs expand in response to injury and were highly suppressive when compared to CD44low Tregs. T cell receptor (TCR) repertoire analysis revealed that the CD44high Treg population undergo TCRαβ clonal expansion as well as increased TCR CDR3 diversity. Bulk RNA sequencing and single-cell RNA sequencing with paired TCR clonotype analysis identified unique differences between CD44high and CD44low Tregs and specific upregulation of genes in Tregs with expanded TCR clonotypes. Gene ontology analysis for molecular function of RNA sequencing data identified chemokine receptors and cell division as the most enriched functional terms in CD44high Tregs versus CD44low Tregs. Mass cytometry (CyTOF) analysis of Tregs from injured and uninjured mice verified protein expression of these genes on CD44high Tregs, with injury-induced increases in Helios, Galectin-3 and PYCARD expression. Taken together, these data indicate that injury triggers the expansion of a highly suppressive CD44high Treg population that is transcriptionally and phenotypically distinct from CD44low Tregs suggesting that they actively participate in controlling immune responses to injury and tissue damage.</p
Image_5_Distinct Injury Responsive Regulatory T Cells Identified by Multi-Dimensional Phenotyping.tif
No full textCD4+ regulatory T cells (Tregs) activate and expand in response to different types of injuries, suggesting that they play a critical role in controlling the immune response to tissue and cell damage. This project used multi-dimensional profiling techniques to comprehensively characterize injury responsive Tregs in mice. We show that CD44high Tregs expand in response to injury and were highly suppressive when compared to CD44low Tregs. T cell receptor (TCR) repertoire analysis revealed that the CD44high Treg population undergo TCRαβ clonal expansion as well as increased TCR CDR3 diversity. Bulk RNA sequencing and single-cell RNA sequencing with paired TCR clonotype analysis identified unique differences between CD44high and CD44low Tregs and specific upregulation of genes in Tregs with expanded TCR clonotypes. Gene ontology analysis for molecular function of RNA sequencing data identified chemokine receptors and cell division as the most enriched functional terms in CD44high Tregs versus CD44low Tregs. Mass cytometry (CyTOF) analysis of Tregs from injured and uninjured mice verified protein expression of these genes on CD44high Tregs, with injury-induced increases in Helios, Galectin-3 and PYCARD expression. Taken together, these data indicate that injury triggers the expansion of a highly suppressive CD44high Treg population that is transcriptionally and phenotypically distinct from CD44low Tregs suggesting that they actively participate in controlling immune responses to injury and tissue damage.</p
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