1,354,607 research outputs found
Influence of Pyramidal M20 (M =Cu, Ag and Au) Clusters on SERS and Noncovalent Interactions toward Tuberculosis Drug Pretomanid (PTD): DFT Study
No full textThe study of interaction and adsorption of drug molecules on the active surface of noble metal nanocluster is of particular interest due to effective change in the properties of the drug molecules. Surface-enhanced Raman scattering (SERS) theoretical calculations were performed to investigate the adsorption properties of pretomanid (PTD) on pyramidal Ag20/Au20/Cu20 metal clusters. The charge transfer process from the M20 pyramids is revealed by MEP and electronic analysis. The frequencies of PTD are enhanced in the PTD–metal complexes due to the noticeable SERS effect, and the binding energies were calculated to be −36.2 kcal/mol, −46.3 kcal/mol and −43.6 kcal/mol with Ag, Au and Cu structures, respectively. For the PTD–metal clusters, there is an entire potential rearrangement due to adsorption process which is due to charge transfer and adsorptions as chemisorption. The polarizability variations are predicted in the order PTD–Au > PTD–Cu > PTD–Ag which contribute the SERS enhancement due to adsorption. Changes in thermodynamic parameters reveal that adsorption is exothermic and at the same time spontaneous with ordered interactions due to the negative values. There is a redshift for the ultraviolet–visible (UV–vis) absorption of PTD–metal complexes with a lowering intensity in comparison with that of PTD, more likely indicating a chemisorption process. SERS enhancement factors are remarkable due to adsorption of conformationally flexible PTD on metal clusters. The noncovalent interactions between PTD and the metal pyramids were also determined. The study provided key information on designing a molecular structure with a good pharmacological profile by calculating bioactivity and drug similarity parameters for bioactive drug molecules
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Morphotectonic study of the Brahmaputra basin using geoinformatics
No full textThe Brahmaputra river basin occupies an area of 580,000 km2 lying in Tibet (China), Bhutan, India and Bangladesh. It is bounded on the north by the Nyen-Chen-Tanghla mountains, on the east by the Salween river basin and Patkai range of hills, on the south by Nepal Himalayas and the Naga hills and on the west by the Ganga sub-basin. Brahmaputra river originates at an elevation of about 5150 m in southwest Tibet and flows for about 2900 km through Tibet (China), India and Bangladesh to its mouth in the Bay of Bengal. The Brahmaputra river basin is investigated to examine the influence of active structures by applying an integrated study on morphotectonics, SRTM, and seismic data. The indices for morphotectonic analysis, viz. basin elongation ratio (Re) indicated tectonically active, transverse topographic symmetry (T = 0.018–0.664) indicated asymmetric nature, asymmetric factor (AF=33) suggested tilt, valley floor width to valley height ratio (Vf = 0.0013–2.945) indicated active incision and mountain-front sinuosity (Smf = 1.11-1.68) values indicated active tectonics in the area. Two prominent knicks on the long profile at distances of about 1600 km and 1900 km closely correlate to the two prominent peaks on the SL index. The first one represents the Indus - Tsangpo suture zone after crossing which the Brahmaputra (Tsangpo) enters the Himalayas and the second one represents the zone where the Dihang (Brahmaputra) comes out of the Himalayas after crossing the Main Boundary Thrust. A great or major earthquake in the modern times, in this region may create havoc with huge loss of life and property due to high population density and rapidly developing infrastructure.
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Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Understanding Trimipraminium Maleate (TPM) through Spectroscopic, Hirshfeld surface and reactivity analysis: Experimental, DFT and MD studies in different solvents at different temperatures
No full textDispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
No full textThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
The Thursday Murder Club: Launching a megabrand author - a publishing case study
No full textIn 2020, the Christmas book charts in the UK made headlines: Barack Obama’s eagerly awaited autobiography, The Promised Land, was beaten to the top spot by The Thursday Murder Club by Richard Osman, a debut cosy crime novel set in a retirement village. Not only did Osman’s book beat the former US president’s expected bestseller, it also broke records, becoming the fastest-selling debut crime novel of all time. Although Osman has a certain level of fame in the UK from his TV appearances on shows such as Pointless, his celebrity status does not entirely explain the novel’s huge sales. This article tracks the acquisition, publication, and promotion journey of The Thursday Murder Club in order to understand the industry and cultural context of its success and to interrogate the role of celebrity in the creation of author brands. The findings suggest that the unexpected scale of the success of the book owed to a number of factors, including in-depth editing by the novel’s agent, editor, and author to tighten up the plot, an extensive and strategic promotional campaign, the pandemic (which drove interest in the book’s genre and themes), and the quality of the writing. We find that the book’s success was accentuated by Osman’s celebrity status rather than being entirely reliant on it. This research adds to the growing scholarship on celebrity authorship by means of an in-depth case study and provides insight into the processes behind publishing a ‘celebrity’ book and launching a megabrand author
Effect of Geometric-Based Coronary Calcium Volume as a Feature Along with its Shape-Based Attributes for Cardiological Risk Prediction from Low Contrast Intravascular Ultrasound
No full textThe assessment and study of sensitivity analysis of cardiological risk using coronary calcium quantification in patients with increased neurovascular risk is considerably enhanced by taking normalized calcium volume and shape-based coronary lesion characteristics as features. Intravascular ultrasound images were acquired from 92 patients with stable angina pectoris. The risk quantification of each patient was performed by computing different shape-based features of the coronary calcium lesions, namely: (i) mean lesion thickness, (ii) mean standard deviation of lesion thickness, (iii) mean centreline lesion length, (iv) mean length of all lesion branches, (v) mean span (arc angle) of the detected lesion, (vi) mean lesion irregularity, and (vii) lesion distance to catheter center. For normalized calcium volume in IVUS coronary arteries, we adapted a geometric-based segmentation strategy by suppressing the non-calcium region thereby isolating the calcium lesion. Our results demonstrate that the area under the curve (AUC) was 0.616 when combining volume feature with shape-based features in comparison to 0.58 when using shape-based features alone. Receiver operating characteristic (ROC) curve analysis shows that the statistical significance of the established association helps in analysing the sensitivity of coronary calcium quantification in neurological risk patients. The analysis reports show an improvement in AUC by 6.2% when using the combination of volume and shape-based features compared to shape-based features alon
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