86,591 research outputs found
Effects of Propionyl-Carnitine in Patients with type2 diabetes and peripheral vascular disease
No full textEffects of propionyl-carnitine in patients with type 2 diabetes and peripheral vascular disease: results of a pilot trial.
Ragozzino G, Mattera E, Madrid E, Salomone P, Fasano C, Gioia F, Acerra G, del Guercio R, Federico P.
SourceDepartment of Internal Medicine, Clinical Methodology and Medical Angiology, Second University of Naples, Italy. [email protected]
Abstract
OBJECTIVE: To assess the efficacy of propionyl-carnitine (PC) in patients with type 2 diabetes and peripheral arterial disease (PAD).
PATIENTS AND METHODS: This was an open pharmacodynamic study. Twenty-four obese patients with type 2 diabetes and PAD (stage IIb) were enrolled in the study. After an initial run-in period of 7 days on a low-calorie diet (1600 +/- 150 kcal/day), patients received intravenous PC (600mg in 100mL saline solution Na/K 0.9%) twice daily for 10 days (T1).
RESULTS: Treatment with PC produced statistically significant increases in maximal walking distance (30%; p < 0.05) and initial claudication distance (15%; p < 0.05) in 15 and eight patients, respectively. In addition, a decrease in dosage of oral antihyperglycaemic agents was observed in 21 patients at T1. No PC-related adverse effects were reported.
CONCLUSIONS: This study showed that acute intravenous administration of PC in patients with type 2 diabetes with PAD improved PAD-related symptoms as well as glycaemic control
LBW of Similar and Dissimilar Skin-Stringer Joints. Part 1: Process optimization and Mechanical Characterisation.
No full textLaser beam welding of light alloys has always represented a big challenge for both designers and technologists due to the large number of process parameters to take into account and the variable responses of the different materials to be welded. In this paper the results of experimental research on laser beam welds of innovative heat treatable aluminum alloys is reported. The well known T geometry (a stringer welded to a skin) has been considered. Two different skins have been analyzed: AA 2139 and AA 6156, both in form of rolled sheets. Two different stringer have been analyzed: AA 2139 and PA 765, both in form of extruded parts. AA 4047 has been used as filler wire. In the first part of the paper, all the steps leading to the realization of sound welds will be described. The criteria used in order to assess the soundness of a weld was the absence of defects, such as cracks or large pores, verified by means of NDE. In the second part of study, both micro structural analysis and mechanical characterization of welds will be described and discussed. Conclusions will demonstrate the importance of the influence of chemical composition of the parts, above all stringer. The performance of the best welds, however, were very close to those of parent materials
Surgical extrusion: state of the art and literature review
No full textAim Surgical extrusion, also known as intra-alveolar transplantation or intra-alveolar repositioning, is instead defined as the procedure in which the remaining tooth structure is repositioned in a more coronal/supragingival position in the same socket where the element was originally located. Therefore, the present systematic review aimed to describe the indications and results obtained by surgical extrusion technique, analyzing the recent literature.Materials and Methods To perform this review articles were electronically searched in PubMed/MEDLINE, the COCHRANE library and Google Scholar by two independent reviewers, and those that met the eligibility criteria were included.Results 26 articles were included in the qualitative analysis, 14 case reports and 12 case series. The survival rate reported was 100% with documented follow-up from one year to 10 years.Discussion Surgical extrusion technique is a valid therapeutic alternative in cases of fractured teeth and intruders due to trauma or in cases of teeth with coronal-root fracture, surgical extrusion was an effective and predictable technique.Conclusions This surgical technique combined, with modern adhesive techniques and the latest generation materials, allows for highly predictable results from the functional and aesthetic aspects, especially in the anterior region
Resistenza meccanica ed a corrosione di giunti simili a sovrapposizione saldati mediante FSW
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Effects of air pollution on production of essential oil in Feijoa Sellowiana Berg. grown in the "Italian triangle of death"
No full textThe composition of the essential oils of fruits from Feijoa sellowiana grown in the district of Acerra is compared with those collected from unpolluted sites. Essential oils from the fruits of F. sellowiana were analysed by GC/MS. Sixty compounds, representing 96.6% and 97.8% (unpolluted site and Acerra site, respectively) of the oils, were identified. The major constituents were β-caryophyllene (12.4% and 16.8%), ledene (9.6% and 11.1%), α-humulene (6.3% and 8.2%), β-elemene (4.9% and 5.3%) and δ-cadinene (4.7% and 5.2%) in the control site and Acerra site, respectively. The antioxidant components were increased in response to polluted condition. The acetonic extracts of F. sellowiana from both sites were purified to obtain flavone, the compound responsible for antitumoral and antioxidant activity. The amount of the antioxidant flavone was higher in the Acerra site than the control site. Measuring the amounts of these metabolites could represent a new methodology for monitoring air pollution
REDESIGN OF AN AERONAUTICAL COMPOSITE STIFFENED PANEL WITH THE DOUBLE-DOUBLE DESIGN APPROACH
No full textThe tailor ability of composite structures represents a fundamental aspect of their appeal and utility across a spectrum of industries, as unlike traditional materials, they offer unparalleled flexibility in design and manufacturing, allowing engineers to precisely tailor material properties to meet specific performance requirements. The heart of composite tailor ability lies in the ability to control material composition, fiber orientation, stacking sequences, and resin systems during the manufacturing process. Such customization level enables engineers to optimize structures for several applications, balancing factors such as strength, stiffness, weight, durability, and cost-effectiveness. The concept of Double-Double laminates makes it possible to introduce an alternative approach to the design of composite laminate structures, for which to carry out a proper and effective optimization in terms of laminate thickness and plies orientation. The aim is to minimize the use of plies to the minimum required to provide strength to the structure, while ensuring a reduction in the total mass of the component. In this paper, the Double-Double design and the feasibility study of a composite stiffened panel, typically adopted in aircraft structures, has been investigated. This investigation has delved deeper into the implementation of the Double-Double approach in the aviation field and its potential impact on component performance. The findings of the study revealed promising results, demonstrating that the new Double-Double design, optimized to meet the material strength requirements, yielded a remarkable reduction in total mass. Specifically, the optimized design achieved a mass reduction of up to 26.48% compared to the initial design configuration. This substantial decrease in weight not only contributes to improved fuel efficiency and operational performance but also aligns with the aerospace industry's ongoing efforts to enhance sustainability and reduce environmental impact
Retrospective Radiographic Analysis of Peri-Implant Bone Loss in Mandibular Full-Arch Implant Rehabilitations
No full textObjectives: Can the type of implant rehabilitation influence peri-implant bone loss in case of full-arch mandibular prosthesis? The purpose of the study was to assess, using orthopantomograms (OPGs), the bone loss around implants in different types of implant-supported prosthetic rehabilitations and identify potential risk factors, associated with the number and location of implants, that may have an association with bone defects. Methods: A radiographic study was conducted on 22,317 OPGs from 2010 to 2024. All OPGs with implant-supported prosthetic mandibular rehabilitations were included in the study. Results: A total of 155 OPGs were evaluated, with peri-implant bone loss identified in 64 (41.3%). Distal implants (furthest from the center) across various positioning patterns were most susceptible to bone loss, with positions 3.6 and 4.6 demonstrating the most frequent occurrence (25 and 26 cases, respectively). The χ2 test revealed significant associations between both the implant positioning pattern (p < 0.001) and number of implants (p < 0.001) with peri-implant bone loss. Also, by updating the sample of OPGs, increased susceptibility to bone resorption was found for implants placed distal to the mental foramen compared to mesial ones in full-arch-implant-supported fixed prostheses. Conclusions: Prospective clinical studies will therefore be useful in investigating this finding further
The outcome of tilted distal implants immediately loaded under screw-retained cross-arch prostheses. A 5-year retrospective cohort study
No full textAim The aim of this retrospective cohort study was to evaluate the clinical outcome of tilted distal implants immediately loaded with metal-resin screw-retained cross-arch fixed prostheses 5 years after loading. Material and Methods One-hundred-seventy-six consecutive patients received four to six implants to be placed with a torque superior 35 Ncm. Two-hundred-nineteen metal-resin screw-retained fixed prostheses (120 mandibular and 98 maxillary) were to be delivered within 3 days. Implant failures and biological complications were evaluated by the treating clinician. Results A total of 922 implants were placed, 407 of which were tilted distal implants. Two patients dropped-out (died). Five years after loading all patients were wearing fixed prostheses. Ten tilted distal implants failed in 9 (5.17%) patients versus six non-distal implants in five patients (2.87%). Fifty-one biological complications occurred at tilted distal implants in 42 patients (24.14%) versus 37 complications occurred at non-distal implants in 24 patients (13.79%). Conclusions In conclusion, tilted distal implants have a double chance of failing or having biological complications when compared to mesial implants
On the Accuracy of Dielectric Characterization of Solid Materials by Open-Ended Coaxial Cable
No full textIn the field of electromagnetic characterization of solid materials, waveguides have long been regarded as the gold standard. However, when dealing with high-technology epoxy resins, this method can be inefficient as it may require a large amount of material resulting in a huge expense in manufacturing the prototype under test and associated additional costs. Alternatively, a method employing an in-house open-ended coaxial probe technology is presented in this work. Specifically, the proposed technique can be applied to broadband assess the dielectric properties of resins in a more cost-effective and non-destructive manner, utilizing a small amount of material. In the literature, it is well stated that the main drawback in the dielectric characterization of solid material by using open coaxial probe is the formation of air gaps at the probe tip-to-material interface. To overcome these limitations, we have designed an appropriate mechanical support. To evaluate the reliability of the method, experimental measurements were performed in the 6.4 GHz-8.2 GHz frequency range and then compared with standard waveguide measurements. This study demonstrates that the proposed system is a valid alternative for preliminary dielectric characterization of hard materials such as epoxy resins
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