32 research outputs found
Kronik böbrek yetmezlikli hastalarda aterosklerotik kardiyovasküler hastalığın erken belirleyicisi olarak asimetrik dimetil arjininin rolü
No full textBu çalışma Pamukkale Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi'nin 12.11.2009 tarih ve 2009 TPF013 nolu kararı ile desteklenmiştir.Kardiyovasküler hastalıklar patofizyolojisinde geleneksel ve geleneksel olmayan birçok risk faktörüne bağlı olarak kronik böbrek yetmezliğinde morbidite ve mortalitenin en önemli nedenidir. Asimetrik dimetil arjinin (ADMA), nitrik oksit sentazın endojen inhibitörü olup kardiyovasküler hastalıklar için önemli bir risk faktörüdür. Karotis intima media kalınlığı (karotis IMK) ve koroner arter kalsifikasyon skoru (KAKS) kardiyovasküler hastalığın erken belirleyicisi olarak kullanılmaktadır. Bu çalışmada erken aterosklerozun göstergesi olan karotis IMK ve KAKS ile asimetrik dimetil arjinin, Hs-CRP, lipoprotein (a), nitrit, nitrat düzeyleri ve diğer konvansiyonel risk faktörlerinin arasındaki ilişkinin araştırılması amaçlandı. Çalışmaya bilinen kardiyovasküler hastalığı ve diyabeti olmayan, yaş ve cinsiyeti uyumlu 38 prediyaliz hastası, 39 diyaliz hastası ve 46 kontrol alındı. ADMA, Hs-CRP, homosistein, nitrik oksit, lipoprotein(a), HOMA-IR düzeyleri ölçüldü. Ultrasonografiyle karotis İMK ve bilgisayarlı tomografiyle koroner arter kalsifikasyon skoru ölçümleri yapıldı. Karotis İMK hem prediyaliz (0,74±0,20 mm) hem de diyaliz hasta grubunda(0,78±0,16 mm) kontrol grubuna (0,56±0,11 mm) göre yüksek saptandı (p=0,001). Koroner arter kalsifikasyon skoru diyaliz hasta grubunda daha fazla olmak üzere hem prediyaliz (64,79±143,02) hem de diyaliz grubunda(701,97±1437,03) kontrol grubundan (28,95±158,65) yüksek saptandı( sırasıyla p=0,003, p0,001). ADMA düzeyleri diyaliz grubunda (1,44±0,58 ?mol/L) ve prediyaliz grubunda (1,04±0,43 ?mol/L) kontrol grubundan (0,69±0,56 ?mol/L), (p0,001) yüksek olarak saptandı. İnflamasyon belirteci olarak bakılan Hs-CRP böbrek yetmezliği olan hastalarda kontrol grubuna göre daha yüksek olmasına rağmen istatistiksel anlamlılık göstermedi. Homosistein düzeyleri tüm gruplarda benzer olarak saptandı. Aterosklerotik ve inflamatuvar bir belirteç olan Lp (a) diyaliz hastalarında (40,07±24,42 mg/dl) ve prediyaliz hastalarında (35,63±24,48mg/dl) kontrol grubuna (23,77±14,01mg/dl) göre anlamlı yüksek saptandı (sırasıyla p=0,002, p=0,035). Tüm hasta grubunda karotis İMK ile yaş, sigara maruziyet süresi, kreatinin, fibrinojen, ürik asit, CRP, P, Ca-P çarpımı, ALP, PTH, ADMA, nitrat ve KAKS ile pozitif ilişki; VKİ, albümin, total kolesterol, LDL ve HDL kolesterol ile negatif ilişki saptandı. KAKS ile tüm hasta grubunda yaş, sigara süre, ALP, PTH, Hs-CRP, Lp (a), ADMA, nitrit, karotis İMK arasında pozitif ilişki, VKİ, albümin, total kolesterol, LDL ve HDL kolesterol ile negatif ilişki saptandı. ADMA ile tüm hasta grubunda serum kreatinini, P,Ca-P çarpımı, PTH, ALP, trigliserid ve karotis İMK ile pozitif ilişki; VKİ, HDL kolesterol ve MDRD- GFR ile negatif ilişki saptandı. Diyaliz hastalarında diyaliz süresi ile KAKS, ADMA ve Hs-CRP arasında pozitif korelasyon saptandı. Tüm kronik böbrek yetmezliği hastalarında böbrek yetmezliği süresi ADMA ve KAKS ile pozitif ilişki saptandı. Tüm hasta grubu ve tüm kronik böbrek yetmezliği hastalarında HOMA-IR ile Lp (a) düzeyleri arasında pozitif ilişki saptandı. Bu çalışmada kronik böbrek yetmezliğinin erken evrelerinden itibaren aterosklerozun başladığı ve renal replasman tedavileri ile sürecin hızlanarak devam ettiği gösterilmiştir. ADMA ile karotis İMK ve koroner arter kalsifikasyon skoru yanında kalsifikasyon parametreleri ve dislipidemi arasında anlamlı korelasyon saptanması ADMA'nın aterosklerotik hastalığın ve kalsifikasyonun erken belirleyicisi olarak kullanılabileceğini düşündürmüştür.Cardiovascular diseases remain the main cause of morbidity and mortality in patients with chronic renal failure due to complexity of its pathophysiology including multiple traditional and non-traditional risk factors. Plasma asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is a potential risk factor for cardiovascular disease. The carotid intima-media thickness (IMT) and coronary artery calcification score (CACS) are used as early predictors of cardiovascular diseases. The study was performed to assess the relationship between premature atherosclerosis as determined by carotis IMT and CACS and plasma ADMA, high sensitive CRP (Hs-CRP), lipoprotein (a), nitrite, nitrate levels, as well as other conventional risk factors in uremic patients. The study was performed on 38 predialysis and 39 dialysis patients and 46 non-uremic controls which were nondiabetic and matched for age and sex. Plasma ADMA, Hs-CRP, homocysteine, nitric oksit, lipoprotein(a), HOMA-IR index were determined. Carotid IMT was measured by high resolution B-mode ultrasonography. CACS was measured by multislice computed tomography. Carotid IMT values were higher in dialysis (0,78±0,16 mm) and predialysis patients (0,74±0,20 mm) than control group (0,56±0,11 mm) ( p0,001). CACS were found to be higher in dialysis (701,97±1437,03) and predialysis patients (64,79±143,02 ) than controls (28,95±158,65) (p=0,003, p0,001 respectively,). Similarly, plasma ADMA levels were higher in dialysis (1,44±0,58 ?mol/L) and predialysis patients (1,04±0,43 ?mol/L) than controls(0,69±0,56 ?mol/L). (p0,001). The Hs-CRP levels as an inflammatory marker were higher in renal failure group than control group, but there was no statistical difference. Homocysteine levels were similar in both patient and control groups. Lipoprotein (a) levels as an atherosclerotic and inflammatory marker, were higher in dialysis (40,07±24,42 mg/dl) and predialysis patients (35,63±24,48 mg/dl) than control (23,77±14,01 mg/dl) group (p=0,002, p=0,035, respectively) . In the analysis of total cohort carotid IMT showed positie correlation with age, cigarette, creatinin, uric acit, fibrinogen, CRP, P, Ca-P product, ALP, PTH, ADMA, nitrate and CACS,and showed negative correlations with total, LDL and HDL cholesterol, BMI, serum albumine levels. In the analysis of total cohort CACS showed positive correlations with age, cigarette, ALP, PTH, Hs-CRP, Lp (a), ADMA, nitrite, carotid IMT, and showed negative correlations with total, LDL and HDL cholesterol, BMI, serum albumine levels. In the analysis of total cohort ADMA showed positive correlations with creatinin, P, Ca-P product, ALP, PTH, TG, carotid IMT, and showed negative correlation with BMI, MDRD- GFR and HDL cholesterol levels. In dialysis patients duration of dialysis showed positive correlations with CACS, ADMA and Hs-CRP. In all chronic renal failue patients there was a positive relationship between duration of renal failure and ADMA, CACS. In the analysis of total cohort and all renal failure patients HOMA-IR showed positive correlation with Lp (a) levels. The study showed that atherosclerosis started from the very early stages of chronic renal failure and continued progresively with the renal replacement therapy. Because of having significant correlations with calcification parameters and dyslipidemia, ADMA levels can be used as an early predictor of calcification and atherosclerotic diseases
6. ve 7. sınıf öğrencilerinin fen-teknoloji-toplum-çevre ilişkilendirmelerini geliştirmeye yönelik bir eylem araştırması: çevremi eğitiyorum
No full text06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması, Düzenlenmesi ve Erişime Açılmasına İlişkin Yönerge” gereğince tam metin erişime açılmıştır.Bu çalışma 6. ve 7. sınıf öğrencilerinin, ebeveynlerini ve yaĢadıkları çevre halkını Fen-Teknoloji-Toplum-Çevre iliĢkilendirmeleri hakkında bilgilendirmelerini konu edinen bir eylem araĢtırmasıdır. Bu kapsamda öğrencilerden 6. sınıf "Canlılarda Üreme, Büyüme ve GeliĢme" ve 7. sınıf "Vücudumuzdaki Sistemler" ünitesindeki Fen-Teknoloji-Toplum-Çevre iliĢkilendirmelerini içeren kazanımlar doğrultusunda afiĢ, poster, drama vb. öğretim materyalleri hazırlamaları istenmiĢ, araĢtırmanın sonunda öğrenciler ebeveynlerini bilgilendirecekleri bir bilim Ģenliği yaparak hazırladıkları materyalleri yaĢadıkları köy halkına sunmuĢlardır.AraĢtırmanın çalıĢma grubunu Sakarya Ġli, Adapazarı ilçesinde bulunan taĢımalı sistemle eğitim yapan bir okulun 6. sınıfında öğrenim gören 33 öğrenci ve 7. sınıfında öğrenim gören 28 öğrenci olmak üzere toplam 61 öğrenci, 11 veli, köy halkından 5 birey ve köy muhtarı oluĢturmaktadır. 2011-2012 eğitim-öğretim döneminde gerçekleĢtirilen bu çalıĢmada araĢtırmacı öğretmen, birincil veri kaynağı olarak açık uçlu soru formu, gözlem ve doküman (öğrencilerin hazırladıkları materyaller, öğrenci mektupları, alan notları) kullanmıĢ; ikincil veri kaynağı olarak da görüĢmelerden faydalanmıĢtır. ÇalıĢmada elde edilen veriler sonuçların analiz edilmesi ve yorumlanması için uygun bir biçimde kullanılmıĢtır. AraĢtırmada elde edilen veriler açık kodlama tekniği ile kodlanmıĢ ve temalaĢtırma yapılmıĢtır. Dokümanlardan örnekörnekler alınarak kodlar ve temalar detaylandırılmıĢtır. ixAraĢtırmanın baĢında öğrenciler organik tarım, ergenlik, canlılarda üreme, sindirim ve boĢaltım sistemi, duyu organları, engelli olmak, organ bağıĢı, bağımlılıktemalarında FTTÇ iliĢkilendirmeleri ile ilgili yeteri kadar bilgi sahibi olmadıkları fakat araĢtırmanın sonunda bu konulara iliĢkin biliĢsel düzeylerinde olumlu yönde farklılık sağlandığı tespit edilmiĢtir. AraĢtırmaya dâhil olan velilerin de çocukları aracılığıyla söz konusu konular hakkında bilinçlendikleri gözlemlenmiĢtir. AyrıcaaraĢtırmanın öğrencilere sorumluluk alma, empati kurma, özgüven, kariyer bilinci geliĢtirme, baĢarma hissi, derse yönelik olumlu tutum, duyarlılık gibi duyuĢsal geliĢim alanlarında katkı sağladığı gözlenmiĢtir. Fen ve Teknoloji dersi kapsamında öğrencilerin FTTÇ iliĢkilendirmelerini arttıracak yönde proje geliĢtirme ve öğrenme sorumluluğu alarak öğretmeye yönelik aktivitelerin farklı sınıf seviyelerinde ve farklı sosyo-ekonomik düzeydeki okullarda yapılması, halkın fen okuryazarlığını ve sosyobilimsel konularda farkındalıklarını geliĢtirmeye yönelik çalıĢmalar yapılması bu çalıĢmadan elde edilen sonuçlar doğrultusunda önerilmiĢtir.Anahtar Kelimeler: Fen Öğretimi, Fen-Teknoloji-Toplum-Çevre ĠliĢkilendirmeleriThis study is an action research that deals with 6th and 7th grade students‟ activities to keep informed their parents and their close environment about science, technology, society and environment associations. In this context, 6th grade students for the chapter in the name of "Procreation, Growth and Development of Creatures" and 7thgrade students for the chapter in the name of " System of Our Body" were asked to prepare posters, banners, role-plays suitable for educational attainments of science, technology, society and environment associations. At the end of the study, students displayed their materials to their close environment by organizing science-fest.The sample of the study consists of 33 students in 6th. grade and 28 students in 7thgrade from a mobile educating school and 11 parents, 5 people from the village and a local authority in Adapazarı which is a county of Sakarya. In the study which was conducted 2011-2012 academic year document analysis, observation and open-ended question form (materials prepared by students, students‟ letters and researcher‟s diary) as primary data source and interviewed as secondary data source were used. In the study data collected from the sources has been used properly to analyze and interpret the results. Collected data was coded with straight-line coding technique and created themes. Codes and themes were detailed by presenting samples from documents. At the initial stages students were found to have insufficient knowledge about organic agriculture, adolescence, reproductive in living being, digest and urinarysystem, sense organs, being handicapped, organ donation and dependency, but at theend of the study a positive difference has been found out in their cognitive level. It is seen that the parents have been informed about the issues via their children. At the same time the study has support students‟ affective progress in such as taking over responsibility, empathy, self-esteem, developing career consciousness, being achievement, positive attitude towards lesson and sensibility. It is suggested that students to make projects about STSE and to take over the responsibility of learning for teaching activities in different schools from different socio-economic levels, public to make more conscious about scientific literacy and to make studies for developing their awarenes
Anti-Nötrofil Sitoplazmik Antikor İlişkili Vaskülitlerde Hematolojik Parametrelerin Prognostik Değeri
No full textGiriş ve Amaç: Nötrofil-Lenfosit oranı (NLO), Platelet-Lenfosit oranı (PLO) ve Monosit-Lenfosit oranı (MLO) dahil olmak üzere hematolojik parametreler, çeşitli hastalıklarda prognoz ve aktivitenin yeni belirleyicileri olarak gösterilmiştir. Bu çalışmada, anti-nötrofil sitoplazmik antikor (ANCA) ilişkili vaskülit (AİV) tanısı olan hastalarda NLO, PLO ve MLO' nun hastalık şiddeti ve prognozu ile ilişkisini araştırmayı amaçladık.\rGereç ve Yöntemler: 92 AİV hastasının tıbbi kayıtları geriye dönük olarak incelendi. Klinik ve laboratuvar verileri ve hastalık sonuçları kaydedildi. Beş faktör skoru (FFS) ≥ 2 olan hastalar ağır hastalık olarak sınıflandırıldı.\rBulgular: Ortanca yaşı 60 olan 92 hasta dahil edildi. NLO≥4.8 (RR 1.83), PLO≥151.8 (RR 2.02) ve MLO≥0.38 (RR 1.85) olan hastalarda ciddi hastalık riski daha yüksekti. Korelasyon analizinde, NLO, PLO ve MLO, C reaktif protein düzeyi ve eritrosit sedimantasyon hızı (ESH) ile pozitif korelasyon gösterdi. NLO, PLO ve MLO remisyon ile ilişkilendirildi. Sadece PLO'su yüksek olan hastalarda nüks oranı daha yüksekti. MLO ayrıca son dönem böbrek hastalığının (SDBY) gelişimi ile de korele idi. NLO, PLO ve MLO düzeyleri yüksek olan hastalarda böbrek tutulumu daha sıktı.\rSonuç: Tanı anında NLO, PLO ve MLO'nun AİV şiddeti ve prognozu ile ilişkili olduğunu gösterdik. Bu çalışma AİV'li hastalarda MLO'nun hastalık şiddeti ve SDBY ile ilişkisini gösteren ilk çalışmadır
A Study on the Symbolic Language Used in Certain Depictions Portraying Suleyman the Magnificent's Last Military Campaign
No full textThis study is an analysis of the symbolic language observed in a number of miniatures depicting various events from the last years of Suleyman the Magnificent's reign (926-974/1520-1566) until the beginning of that of Selim II (974-982/1566-1574). I will focus especially on the tree stump motif seen in the miniature depicting the event of deploying Suleyman the Magnificent's corpse, attributed to Nakkas Osman (d. after 1001/1592), found in Feridun Ahmed Bey's (d. 991/1583) Nuzhet-i esraru'l-ahyar der-ahbar-i Sefer-i Sigetvar (Pleasures of the Secrets of Auspicious Men from the News of the Szigetvar Campaign, 976/1569), and in the senility portrait of Suleyman the Magnificent attributed to Nigari (d. 980/1572). The tree stump is recognized as a cult motif that heralds the genealogical continuity of religious and political authority. I will argue that in the above mentioned miniatures, it represents the continuity of the dynasty, and the transfer of dynastic power. The tree stump motif and the depictions of nature and of animals in these miniatures were selected to complement the theme depicted and added into the composition to enhance the narrative. There seems to be an obvious interaction among the painter, the poet and the author reflected in the document
FRAILTY AND RELATED FACTORS IN ELDERLY PATIENTS WITH CHRONIC KIDNEY DISEASE
No full textIntroduction: Chronic kidney disease and frailty are two crucial clinical conditions increasing in prevalence globally. Both lead to severe complications that increase mortality and morbidity in patients. Conditions that may potentiate frailty in chronic kidney disease patients may complicate the follow-up of chronic disease and complicate long-term survival in this patient group. In this study, we aimed to evaluate frailty and related factors in chronic kidney disease patients over 65 years of age who were on dialysis and who were not. Materials and Methods: This cross-sectional study was carried out in geriatric chronic kidney disease patients followed in nephrology outpatient clinics or undergoing routine hemodialysis. Frailty was assessed using a scoring scale. Laboratory findings and their relationship with demographic and epidemiological data were investigated. Results: One hundred eighty-eight patients aged 65 and over were included in our study. Of the patients, 92 were female, and 96 were male. The mean age was 72.86 years. We found frailty in 82 patients (43.6%). Female gender, over 75 years old, under dialysis treatment, low-income status, and low education level were parameters significantly associated with frailty. In the regression analysis, we found that economic status and dialysis were variables that independently affected frailty in chronic kidney disease patients. Conclusions: In our study, the frequency of frailty was found to be high. Practical management and early assessment of frailty seem rational with the basic nephrological approach in patients with chronic kidney disease. Considering the high mortality rate among frail patients, we think these patients should be followed up more closely
Kanûnî’nin Son Seferini Konu Alan Bazı Tasvirlerdeki Sembolik Dil üzerine
No full textThis study is an analysis of the symbolic language observed in a number of miniatures depicting various events from the last years of Suleyman the Magnificent’s reign (926-974/1520-1566) until the beginning of that of Selim II (974-982/1566-1574). I will focus especially on the “tree stump motif” seen in the miniature depicting the event of deploying Suleyman the Magnificent’s corpse, attributed to Nakkaş Osman (d. after 1001/1592), found in Feridun Ahmed Bey’s (d. 991/1583) Nüzhet-i esrârü’l-ahyâr der-ahbâr-ı Sefer-i Sigetvar (Pleasures of the Secrets of Auspicious Men from the News of the Szigetvár Campaign, 976/1569), and in the “senility” portrait of Suleyman the Magnificent attributed to Nigârî (d. 980/1572). The tree stump is recognized as a cult motif that heralds the genealogical continuity of religious and political authority. I will argue that in the above mentioned miniatures, it represents the continuity of the dynasty, and the transfer of dynastic power. The “tree stump motif” and the depictions of nature and of animals in these miniatures were selected to complement the theme depicted and added into the composition to enhance the narrative. There seems to be an obvious interaction among the painter, the poet and the author reflected in the document. © 2019 Osmanli Arastirmalari - Journal of Ottoman Studies. All rights reserved
The Effect of High Power Microwave Energy on the Grindability of Turkish Cayirhan Lignite
No full textIn this study, the effect of microwave radiation on grindability of Turkish lignite has been investigated. Turkish lignite (-15 mm, 500 g) was treated by microwave (at a frequency of 2.45 GHz) in a Te010 single mode cavity using a pneumatic system to control the residence time of each sample in the cavity with high-electric-field-strength microwave energy at different power settings (in the range of 5-20 kW) for a short residence time (2 sec). In order to determine the grinding resistance of Turkish lignite samples treated by microwave ovens, the Hardgrove Grindability Test was applied for each treated and untreated sample and also the amount of fine product (-74 m) was evaluated and compared with each other. Experimental results have shown that significant increases in grindability were achieved when the lignite samples were exposed to microwave radiation. The Hardgrove Grindability Index of samples and the amount of fine product increased up to 123 and 117%, respectively.TUBITAK (Turkish Scientific and Technologic Research Association)The author would like to express thanks to Professor Samuel Kingman of the School of Chemical and Environmental and Mining Engineering at the University of Nottingham for the use of equipment and technical assistance. The author is also partially supported by the TUBITAK (Turkish Scientific and Technologic Research Association) and wishes to thank its financial support
Effect of chemical additive on stirred bead milling of calcite powder
No full textThe effect of liquid additive on the dry ultrafine grinding of calcite powder (CaCO3) was investigated by using a stirred bead mill. The experiments were carried out by a batch operation, and the change in particle size distribution (PSD) and volumetric surface area (S-v) (m(2)/cm(3)) of calcite. The results show that the chemical additive promotes the fine grinding of calcite and that the maximum volumetric surface area of calcite obtained with additives 0.2%. (C) 2012 Elsevier B.V. All rights reserved.Nigde University Scientific Research Projects Directorate [FEB2010/01]The author would like to thank the Nigde University Scientific Research Projects Directorate (project no. FEB2010/01) for funding of this research work. And the author acknowledges Nidas Company for providing of sample and grinding aid
Dry Fine Grinding of Calcite Powder by Stirred Mill
No full textThe demand for fine powder is increasing in many fields such as chemical, pharmaceutical, and material industries. Therefore, research in fine grinding has gained in importance. In this study, the effects of various operating parameters, such as grinding time (min), stirrer speed (rpm), feed quantity (% of ball weight), and ball filling ratio (%) on fine grinding of calcite powder (CaCO3) (d(50)=34.04 mu m) were studied using a laboratory vertical stirred mill under dry conditions. A series of laboratory experiments using 2(4) full factorial designs was conducted to determine the optimum grinding parameters. The main and interaction effects on the volumetric surface area (S-v) (m(2)/cm(3)) of the ground product were evaluated using Yates' analysis. The grinding time, media filling ratio, and stirrer speed play distinct roles (positive) in product surface area and fineness.Nigde University Scientific Research Projects Directorate [FEB2010/01]The author would like to thank the Nigde University Scientific Research Projects Directorate (project no. FEB2010/01) for funding of this research work. And the author acknowledges Nidas Company (Nigde, Turkey) for providing of sample
