47,852 research outputs found

    Cross-Cultural Meta-Analyses

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    In the enormous collection of cross-cultural data that have been published during the last few decades it is difficult to perceive patterns. There is a clear need for systematizing the vast amount of cross-cultural studies and for developing models that explain cross-cultural differences in psychology. Two methods of cross-cultural meta-analysis can be distinguished. First, the instrument-based method of comparing data for one instrument across countries is suitable for instruments which have been administered in many countries. Second, a domain-based meta-analysis used a thematic domain from which culture-comparative studies are sampled instead of one specific instrument or method

    Cross-Border Cooperation: Subverting Sovereignty?

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    Work on European spatial planning has led me to criticise what I call territorialism.It conceives of the world in terms of a seamless cover of sovereign stateslooking after its territory each as if it were its property. In the European Unionthough, states are enveloped by a superstructure. Does this mean that there is aEuropean territory and, if so, how does it relate to the territories of its MemberStates? The issue becomes manifest in such efforts, as there have been undertaken,to arrive at a form of European spatial planning.Spatial Planning and Strateg

    First results of cross-correlation analysis of ambient seismic noise from the Hellenic Unified Seismic Network

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    In this study we present phase velocity maps that were obtained from the cross-correlation analysis of ambient seismic noise recorded in the region of Greece.We used one year (2013) of ambient seismic data obtained from the vertical component of 64 broadband permanent seismological stations that are part of the Hellenic Unified Seismic Network. Inter-station istances between these stations ranged from 60 to 840 km and the number of station pairs was 2054. All signals were corrected for instrument response, the trend was removed and the mean was subtracted. The data of each station was split in 4 hr time windows. Each window was systematically searched to remove earthquake signals and instrument problems and then the remaining 4 hr windows were spectrally whitened. For the last stage of the processing, the 4 hr data of each station pair were independently cross-correlated and then were stacked over the whole year into one time-series. This cross-correlation function contains the causal and acausal part of the Green’s function of the medium between these two stations. Because ambient noise sources are not uniformly distributed, these two parts of the Green’s function (causal and acausal) are not identical. In our analysis we used the part of Green’s function that has the strongest and cleanest amplitude. Then, the individual phase velocity dispersion curves are obtained for all the cross-correlation functions by using frequency time analysis. Finally, the phase velocity curves are used to create phase velocity maps in the period band of 8 to 30 sec. These maps in a later stage will be inverted for shear-velocity structure

    Holy Cross Magazine, Vol. 46, No. 1, Winter 2012

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    Syllabus: Multicultural Education with Associate Professor Ericka J. Fisher ’96 By Pam Reponen A Portrait of a Presidency Together with Fr. McFarland, the Holy Cross community reflects on and celebrates 12 years of change, growth and sustained commitment to mission By HCM, Ruth Ann Elias ’76, Timothy R. Austin and Fr. McFarland Photography by Patrick O’Connor Fr. Editor-in-Chief Noted religious history author, editor and Holy Cross professor, Rev. Thomas Worcester, S.J., takes on an impressive new challenge. By Rebecca Smith ’99 Living, Learning, Laughing The residence life experience at Holy Cross integrates opportunities to grow in academics, faith, spirituality and, of course, friendship. More than a place to hang a backpack at night, the College’s residence halls are designed to foster meaningful moments for students. By Mark C.N. Sullivan Photography by Matthew Atanian Service with Ignatian Spirituality Across the nation, Crusaders of a certain age are finding spiritual fulfillment as part of the Ignatian Volunteer Corps By Mike Cullity ’94 Ice in Their Veins Brother and sister Crusaders, Jeff Reppucci ’14 and Dara Reppucci ’04, share a love of the rink, but each came to the game on a unique path. By John W. Gearan ’65 Discovery of an Artist Crusader legend and Celtics great Tom Heinsohn ’56 is as comfortable at his easel as he is on the court. By Mark Murphy Profile: Marian Earls, M.D., ’76 and Naomi Earls Leslie, M.D., ’00 By Corrie Lisk-Hurst Your Turn: Coach, Remembered By Jay McGovern ’73 Also: Campus Notebook Book Notes Gifts at Work Sports Alumni News In Memoriamhttps://crossworks.holycross.edu/hcm/1051/thumbnail.jp

    Holy Cross Magazine, Vol. 58, No. 3, Fall 2024

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    How Holy Cross Is Creating a Community That’s Not Afraid To Speak UpIt’s a hard time to talk about tough topics, yet that’s exactly what the College wants its students to do.Story by Marybeth Reilly-McGreen ’89 How Maia Lee-Chin Went From Fenwick Scholar to Bestselling Author The classic major’s new book, “Et Cetera: An Illustrated Guide to Latin Phrases,” highlights shared human experience — even over several millennia. Story by Marybeth Reilly-McGreen ’89 Rust Spots, Broken Radio and a Door That Doesn’t Open: Inside the True Value of a Family Van Reflection by Ronan Flanagan ’28 Amplifying the Voices of Women in Jazz Vocalist Rhiannon Hurst ’25 is using Holy Cross’ highest academic honor to examine and spotlight the music of women and nonbinary jazz artists. Story by Billy McEntee Holy Cross History Reveals The Power of Hope Inside the vital tie between hope and education. Reflection by Rev. Paul F. Harman, S.J., Hon. ’24 Fitness For All: Inside Improvements Needed for Gym Accessibility “What I have found is that ADA compliance does not mean that it is accessible,” says William Schutte ’26. Story by Maura Sullivan Hill She Was Supposed to Go to Law School. Instead, She Opened a Dispensary. Payton Shubrick ’15 wants you to rethink cannabis — and a whole lot of other things, too. Story by Marybeth Reilly-McGreen ’89 Photography by Michael Ivins Divided Democracy — The Past is (Frighteningly) Never Dead Reflection by Thomas R. Martin Illustration by Stephen Albano “What Business Are You In … Really?” Reflection by Julie Halpin Anderson ’84 Also: Where in The Hill is This? Around The Hill My Bag: Jennifer Tefft ’93, Musician, Songwriter and Performer In Memoriam Can We Ask You Some Questions, Connor Zanini?https://crossworks.holycross.edu/hcm/1002/thumbnail.jp

    Holy Cross Magazine, Vol. 48, No. 3, Summer 2014

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    Syllabus: Book Projects with Associate Professor Susan Schmidt By Pamela Reponen The Writing Life In Holy Cross classrooms, critically acclaimed author Leah Hager Cohen engages students in questions that are integral to her teaching and work: the value of creativity and the abundant gifts that come from making art. By Julie Wittes Schlack Photos by Louie Despres Moonwalking in Mongolia Stephen A. Dutton ’08 discovers Jesuit principles in action on a chance visit to the outskirts of Mongolia’s capital city. Words and photos by Stephen A. Dutton ’08 The President’s Counselor As he steps down from a long and successful tenure with the Board of Trustees, P. Kevin Condron ’67 talks with HCM about his legacy, the future of Holy Cross and all he has seen in his many years on The Hill. By John Marchese Profile: Jim Speltz ’97 Leadership learned on The Hill has helped Jim Speltz ’97 shepherd the unique company he loves through troubled water. By Mike Cullity ’94 Flashback: The Costello Collection A dusty box, forgotten for decades in an attic, reveals ties to The Hill and a surprising family discovery. By John Gearan ’65 “Faith, Family and Friends” For Bill McMahon ’80, an avid golfer who happens to be blind, these three words have become a life mantra. And now, faith, family and friends are needed to help McMahon clear the latest in a long line of health hurdles. By John Gearan ’65 Ski, Fish, Bike … and Give Back Bill Maloney ’59\u27s dedication to Holy Cross comes full circle with his recent bequest By Rebecca Sullivan Delaney ’98 Your Turn: The Crusader By Aline (Doino) Weiller ’87 Also: Campus Notebook Book Notes Sports The Power of One Alumni News In Memoriamhttps://crossworks.holycross.edu/hcm/1041/thumbnail.jp

    High-resolution numerical analysis of turbulent flow in straight open ducts with rectangular cross-section

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    Turbulent secondary flow in straight open ducts with rectangular cross-section are studied numerically by means of pseudo- spectral direct numerical simulation (DNS). Similarly to the corresponding closed duct flows, the mean streamwise vorticity pattern in turbulent open duct flows were found to be the statistical footprint of the most probable locations of the quasi-streamwise vortices. A major difference between the two configurations was found in the vicinity of mixed-boundary corners where noticeably persistent vortical structures exist.Turbulent secondary flow in straight open ducts with rectangular cross-section are studied numerically by means of pseudo- spectral direct numerical simulation (DNS). Similarly to the corresponding closed duct flows, the mean streamwise vorticity pattern in turbulent open duct flows were found to be the statistical footprint of the most probable locations of the quasi-streamwise vortices. A major difference between the two configurations was found in the vicinity of mixed-boundary corners where noticeably persistent vortical structures exist

    Holy Cross Magazine, Vol. 55, No. 1, Winter 2021

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    Bring Kimball to Your Kitchen Recipes: Baked Buffalo Chicken; Sautéed Cabbage with Basil; Kimball bakery Magic Bars; Crossroads mac and Cheese Faculty Film Explores the Indigenous and Environmental History of Holy Cross Professors highlight the history of the Nipmuc, the Blackstone River, the College campus and its surrounding neighborhood By Mary Cunningham ’17 Faculty/Student Research Aims to Discover More About Breast Cancer Tumors By Maura Sullivan Hill Syllabus: Eating and Its Disorders with Jumi Hayaki, professor of psychology By Lori Ferguson “I Mean, Is This Really Happening? It is.” After a career fighting outbreaks from AIDS to Ebola, Anthony Fauci, M.D., ’62, Hon. ’87 became a household name, the medical face of a pandemic and a target. By Marybeth Reilly-McGreen ’89 Ode on a P.O. Box Holy Cross’ classic mailboxes may be gone, but their memory remains for generations of Crusaders. By Marybeth Reilly-McGreen ’89 The Long Intermission Despite a decades-long career as an actor and director, the most critical role for David Saint ’75 may be that of benefactor, helping the country’s live theaters in, literally, their darkest hour Billy McEntee Prolific Ukulele Songbook Writer Keeps Classic Tunes From Fading Out Forever Over the past nine years, Dick Sheridan ’56 has published close to 30 songbooks for a variety of stringed instruments. By Daniella Vollinger Vanecko Shows the World What It Means to “Fight Like A Girl” Inspired by her Fulbright experience in South Africa, Mary Kate Vanecko ’17 launches an international girls boxing and leadership development program By Meredith Fidrocki How Ignatian Tools Can Help You Cope With the Pandemic By Rev. James J. Martin, S.J., author and editor at large of America Magazine Also: Campus Notebook Faculty & Staff Creative Spaces Sports Alumni News Mystery Photo Creative Notes In Memoriamhttps://crossworks.holycross.edu/hcm/1014/thumbnail.jp

    Limited antigenic diversity of Plasmodium falciparumapical membrane antigen 1 supports the development of effective multi-allele vaccines

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    Background: Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism. However, knowledge on antigenic diversity of key antigens, the impact of polymorphism on potential vaccine escape, and how sequence polymorphism relates to antigenic differences is very limited, yet crucial for vaccine development. Plasmodium falciparum apical membrane antigen 1 (AMA1) is an important target of naturally-acquired antibodies in malaria immunity and a leading vaccine candidate. However, AMA1 has extensive allelic diversity with more than 60 polymorphic amino acid residues and more than 200 haplotypes in a single population. Therefore, AMA1 serves as an excellent model to assess antigenic diversity in malaria vaccine antigens and the feasibility of multi-allele vaccine approaches. While most previous research has focused on sequence diversity and antibody responses in laboratory animals, little has been done on the cross-reactivity of human antibodies. Methods: We aimed to determine the extent of antigenic diversity of AMA1, defined by reactivity with human antibodies, and to aid the identification of specific alleles for potential inclusion in a multi-allele vaccine. We developed an approach using a multiple-antigen-competition enzyme-linked immunosorbent assay (ELISA) to examine cross-reactivity of naturally-acquired antibodies in Papua New Guinea and Kenya, and related this to differences in AMA1 sequence. Results: We found that adults had greater cross-reactivity of antibodies than children, although the patterns of cross-reactivity to alleles were the same. Patterns of antibody cross-reactivity were very similar between populations (Papua New Guinea and Kenya), and over time. Further, our results show that antigenic diversity of AMA1 alleles is surprisingly restricted, despite extensive sequence polymorphism. Our findings suggest that a combination of three different alleles, if selected appropriately, may be sufficient to cover the majority of antigenic diversity in polymorphic AMA1 antigens. Antigenic properties were not strongly related to existing haplotype groupings based on sequence analysis. Conclusions: Antigenic diversity of AMA1 is limited and a vaccine including a small number of alleles might be sufficient for coverage against naturally-circulating strains, supporting a multi-allele approach for developing polymorphic antigens as malaria vaccines
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