1,796 research outputs found
RIC-HSCT for MF/SS
No full textAdvanced-stage mycosis fungoides and Sezary syndrome (MF/SS) have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (HSCT), particularly using a reduced-intensity conditioning (RIC) regimen, is a promising treatment for advanced-stage MF/SS. We performed RIC-HSCT in nine patients with advanced MF/SS. With a median follow-up period of 954days after HSCT, the estimated 3-year overall survival was 85.7% (95% confidence interval, 33.4-97.9%) with no non-relapse mortality. Five patients relapsed after RIC-HSCT; however, in four patients whose relapse was detected only from the skin, persistent complete response was achieved in one patient, and the disease was manageable in other three patients by the tapering of immunosuppressants and donor lymphocyte infusion, suggesting that graft-versus-lymphoma effect and "down-staging" effect from advanced stage to early stage by HSCT improve the prognosis of advanced-stage MF/SS. These results suggest that RIC-HSCT is an effective treatment for advanced MF/SS
Support For IP Mobility and Diversity in a Broadband Wireless Access Network
No full textBroadband wireless access (BWA) network working at millimetre bands possesses the advantages of quick deployment, more flexibility, wide service coverage and cost efficiency. The range of services to be provided via the system includes broadband digital television, Internet data, telephony and videoconference. Apart from broadcast digital television, all traffic is carried in Internetworking Protocol (IP) format.
Unfortunately the services of such a system are susceptible to impairment by buildings, vegetation, terrain and attenuation caused by rain, snow and sleet, etc. Accordingly the service availability and system performance can drop dramatically. In the worst case, the system will experience heavy packet loss and the services might be completely unavailable.
An extended multiprotocol label switching (MPLS) network architecture is proposed in this thesis, which allows fast mobile IP access and diversity routing for traffic under fade condition. This supports nomadic access, reduced packet loss and improved service availability in BWA network during system outage. Also developed herein is a Diversity and Shadow Flow Merging Mechanism, which, besides sending a packet on its normal path, also duplicates the packet and sends it on a separate, diverted labelled path. The shadow flow merging mechanism is responsible for merging the normal flow and shadow flow together and delivering the merged packet to its destination. It is anticipated that the packet can be successfully delivered to the destination even if one path fails completely during the system outage.
The protocol is tested on a general BWA network that is configured with Digital Video Broadcast (DVB) downlink and Multi-Frequency Time Division Multiplex Access (MF-TDMA) uplink equipments. The protocol’s ability of reducing packet loss and improving service availability, during the period of link failure, is verified. It is concluded that the protocol is effective in improving the service availability of BWA network
Preparation of mono-sized epoxy/MF microcapsulesin the appearance of polyvinyl alcohol as co-emulsifier
No full textFor epoxy microcapsules embedded in concrete as mechanic-triggered self-healing adhesive, globular shape with uniform size is the basic requirement to ensure the solid shell broken and the liquid core released at a designed stress. In this paper, monodispersed melamine\u96formaldehyde (MF) resin-walled epoxy E-51 microcapsules were successfully fabricated in an in situ polycondensation process, in which a certain amount of polyvinyl alcohol (PVA) solution was added as coemulsifier to control the microcapsules\u92 shape and size. Detail investigation shows, with the cooperation of PVA, the microcapsule morphologies and size distribution were ease to be adjusted by the parameters such as emulsifying agents, agitation rate, pH value and acidification time
ACT Family Violence Intervention Program review
No full textThis paper reports on a review of the Australian Capital Territory’s Family Violence Intervention Program, which provides an interagency response to family violence matters.
The scope of the review was to analyse the program’s activities and outcomes using 2007–08 data provided by participating agencies, supported by in-depth interviews with key stakeholders including victims whose matters had been finalised in court. After the completion of this report, additional data from 2008–09 and 2009–10 was made available by some Family Violence Intervention Program (FVIP) participating agencies. Although not within the scope of this evaluation, these data pointed to some preliminary improvements in the FVIP
NF membrane fouling by aluminum and iron coagulant residuals after coagulation-MF pretreatment
No full textThe effects of coagulant residuals on fouling of a nanofiltration (NF) membrane were investigated. Experiments were carried out with a laboratory-scale microfiltration (MF)-NF setup and a pilot MF-NF plant. In the laboratory-scale experiments, NF feed water was pretreated with poly-aluminum chloride (PACl) or alum followed by MF. NF membrane permeability declined when the feed water contained residual aluminum at 18 μg/L or more, but not when it was lower than 9 μg/L. When pretreated with ferric chloride, no substantial decline of NF membrane permeability was observed: residual iron did not affect the permeability. When SiO2 was added to the water before the pretreatment with PACl, the NF membrane permeability declined at about double the speed. Thermodynamic calculations and elemental analysis of foulants recovered from the membranes indicated that the majority of inorganic foulants were compounds composed of aluminum, silicate, and possibly potassium. In the pilot plant, NF feed was pretreated by PACl. Transmembrane pressure for NF doubled over 4.5 months of operation. Although the aluminum concentration in the NF feed was not high (30 μg/L), analysis of membrane foulants revealed excessive accumulation of aluminum and silicate, also suggesting that aluminum residuals caused the membrane fouling by alumino-silicates or aluminum hydroxide
Sources
No full textBibliothèque nationale de France, Paris Registres des privilèges accordés aux auteurs et aux librairesMs. Fr. 21 957 (Mf. 9371), 15 mars 1738-5 avril 1742.Ms. Fr. 21 958 (Mf. 8303), 7 avril 1742-26 mai 1748.Ms. Fr. 21 959 (Mf. 9372), 11 juin 1748-11 juillet 1752.Ms. Fr. 21 960 (Mf. 9373), 11 juillet 1752-30 décembre 1755.Ms. Fr. 21 961 (Mf. 9374), 9 juillet 1756-17 juillet 1759.Ms. Fr. 21 962 (Mf. 8304), 18 juillet 1759-28 septembre 1763.Ms. Fr. 21 963, 8 octobre 1763-15 juillet 1766.Ms. Fr. ..
Correction Factor on Dynamic Force in a Marsh Funnel Test for Tunneling
No full textThis paper presents an improvement on a previous model for predicting the Marsh funnel (MF) test that is used in slurry shield tunneling for evaluating the rheological properties of bentonite slurries. The improvement focuses on the prediction of the dynamic part for fluids with small MF times. The velocity profile of the Herschel-Bulkley fluid in a laminar pipe flow condition is first investigated and a correction factor is introduced in the improved model. Comparisons of results from experiments and calculations with the previous model confirm the improved performance over the existing model. The rheological parameters obtained from the improved model show good resemblance to those obtained from a laboratory viscometer. The work also provides a reference to similar applications such as fluid transportation through pipelines where dynamic pressure dominates and therefore should be correctly predicted considering its velocity profile in a laminar condition.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Offshore and Dredging Engineerin
Interactions médicamenteuses entre anti-inflammatoires non stéroïdiens et antihypertenseurs : approches pharmaco-épidémiologiques
No full textCe travail présente une approche conjointe de pharmacovigilance et de pharmaco-épidémiologie pour évaluer les interactions médicamenteuses (IM) entre Anti-Inflammatoires Non Stéroïdiens (AINS) et antihypertenseurs.
La base de données française de PharmacoVigilance et la base de remboursement de l'Assurance-Maladie ont été utilisées.
L'approche de pharmacovigilance a démontré que les patients exposés à ces IM avaient des caractéristiques proches des patients hypertendus en population générale. Cette étude a souligné le risque important de survenue d'insuffisance rénale aigüe par IM des AINS avec les Inhibiteurs de l'Enzyme de Conversion (IEC), les Antagonistes des Récepteurs de l'Angiotensine II (ARA II) et les Diurétiques (phénomène appelé triple whammy).
L'approche de pharmaco-épidémiologie a démontré que la majoration de la pression sanguine artérielle par interaction médicamenteuse des AINS avec les antihypertenseurs se traduisait en population générale par un risque augmenté d'intensification du traitement antihypertenseur (Risque Relatif ajusté pour l'exposition aux AINS : 1,34 [1,05-1,71]). Ce travail a souligné le risque spécifique des interactions entre les AINS et les IEC et/ou les ARA II.
La seconde étude pharmaco-épidémiologique a retrouvé une sécurisation insuffisante de l'initiation d'un traitement AINS chez les hypertendus traités. Le contrôle recommandé de la créatininémie et de la kaliémie chez les sujets traités par IEC, ARA II et diurétiques n'était effectué que dans 10,7% des cas. Ce manquement était plus marqué chez les prescripteurs de médecine générale que chez les autres spécialistes (cardiologues ou anesthésistes).
Les IM entre AINS et antihypertenseurs, bien que classiquement décrites, ont un impact majeur en population.This thesis consists of a mutual approach of pharmacovigilance and pharmacoepidemiology to assess the drug interactions between Non Steroidal Anti Inflammatory Drugs (NSAIDs) and antihypertensives, as close as possible of primary care.
The French pharmacovigilance database and the French health insurance system database have been used.
The pharmacovigilance approach has showed that patients exposed to these drug interactions had similar characteristics with hypertensive patients in general population. This study underlined the important risk of acute renal failure caused by drug interactions between NSAIDs and Angiotensin Converting Enzyme Inhibitors (ACEIs), Angiotensin Receptor Blockers (ARBs) and Diuretics (phenomenon called triple whammy).
The pharmacoepidemiological approach showed that increase in arterial blood pressure caused by drug interactions between NSAIDs and antihypertensives led to a greater risk of antihypertensive treatment intensification (Relative Risk for NSAIDs exposure: 1.34 [1,05-1,71]) in general population. This study underlined the specific risk of NSAIDs interactions with ACEis and/or ARBs.
The second pharmacoepidemiological study showed an insufficiently secure initiation of NSAIDs among treated hypertensive patients. Recommended laboratory monitoring of serum creatinine and potassium were only applied in 10.7% of cases. These insufficiencies were more frequent in general practitioners than other prescribers (cardiologists or anesthesiologists).
Drug interactions between NSAIDs and antihypertensives, although fully described, have a major impact in primary care
La Voix des cloches : bulletin mensuel des œuvres de la rue de la Villette 25
No full textavril 19051905/04 (N17).Note : 02 PI 0114 vues Réd. 22 x S117125 3 mf
Petite revue de la famille : consacrée à la femme et à l'enfant : hygiène, littérature, beaux-arts, théâtres, modes, conseils utiles, etc., etc. / gérant : Dr Kornhold
No full textavril 19031903/04 (A1,N1).Note : 02 PI 0145 vues Réd. 22 x S117127 3 mf
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