1,721,113 research outputs found
Testicular and thyroid function as survival predictors in the elderly patient candidate to surgery
No full textThe relationship between testosterone deficiency (TD) syndrome and surgical resilience has a great impact in the modern approach to male elderly patients. There is good evidence that low levels of T are a strong marker for cardiovascular risk; also, TD is frequently associated with increased cardiovascular and all-cause mortality especially in cardiac older frail men. Screening for low T should be mandatory in high risk groups candidate to surgery including those with diabetes, metabolic syndrome and obesity, even though benefits from T-treatment on survival rates are unclear.The low-T3 syndrome, named non-thyroidal illness (NTI) that occurs during critical illness refers to a syndrome with different faces in both sexes. The acute stress or critical illness-induced alterations within the thyroid axis occur in the first days of critical illness i.e. post-surgery and are brought about at least in part by the concomitant macronutrient deficit. The NTI that occurs in prolonged critically ill patients or in post-surgical resilience patients who continue to be dependent on intensive medical care for weeks or months, may have an impact on surgical outcomes because of frequent occurrence of cardiac arrhythmias. Future directions should better routinely investigate circulating thyroid hormones in population at risk before surgery after excluding iatrogenic drug interferences, and investigate the effect of possible treatments on survival rates after surgery
Idee e prospettive di ricerca. Dal vincolo archivistico al vincolo di integrità.
No full textIl volume, oltre ad affrontare la complessità propria della gestione della documentazione di stato civile, si caratterizza per la trattazione sistematica di temi di grande attualità: il continuo mutamento dello scenario legislativo in materia di procedimenti amministrativi e di informatizzazione della Pubblica amministrazione; la progressiva sostituzione del documento cartaceo con quello digitale e la trasformazione del concetto di "conservazione permanente" in quello di "conservazione a lungo termine"; l'esplorazione delle potenzialità e dei limiti connaturati alle nuove tecnologie come, ad esempio, nel passaggio dalla tradizionale forma cartacea a quella digitale, il mantenimento dei requisiti di affidabilità, autenticità, accessibilità del documento amministrativo, il trattamento e l'accesso ai dati individuali riservati, il rapporto fra costi e benefici nella gestione della documentazione digitale, la ridefinizione delle responsabilità e dei compiti di alcuni profili professionali, fra i quali l'ufficiale di stato civile, l'archivista e l'esperto informatico.
Lo studio è il risultato del lavoro di un gruppo scientifico a carattere multidisciplinare formato da esperti provenienti da differenti ambiti istituzionali pervenuti, attraverso l'impegno comune, alla formulazione di una proposta unitaria e globale, che consente di procedere alla automazione dei registri di stato civile tenendo conto degli aspetti amministrativi, legislativi, normativi, tecnologici ed archivistici del processo, dalla formazione dell'atto di stato civile alla sua conservazione illimitata nel tempo. L'originale proposta di automazione dei registri di stato civile e di conservazione degli atti qui formulata, prende le mosse dalle innovazioni introdotte dal d.p.r. 3 novembre 2000, n. 396, in materia di revisione e semplificazione dell'ordinamento di stato civile, e si struttura in due parti: l'analisi dello scenario esistente, del quadro normativo di riferimento e delle principali criticità del sistema; le proposte di superamento delle criticità e l'elaborazione di un nuovo modello di gestione automatizzato dei flussi, dei registri e dei servizi di stato civile in Italia
Lifestyle and Osteoporosis Risk in Men (Physical Activity, Diet, Alcohol Abuse)
No full textMale osteoporosis is a health problem of multifactorial origin. Bone mineral density evaluation (BMD) by X-ray densitometry allows diagnosis, while stratification of risk fracture is usually done through useful diagnostic tools (i.e., FRAXc). The risk of osteoporotic fracture results from a combination of modifiable and unmodifiable factors. Lifestyle factors are the modifiable factors that can greatly impact on overall health and well-being, including bone health. Many lifestyle factors such as physical activity, diet, alcohol abuse, and smoking can have substantial effects on bone metabolism. Nowadays, the crucial role that lifestyle factors play in the development of male osteoporosis has generated a growing interest in this field of study. Male osteoporosis prevention (or non-pharmacological intervention) should be based on the elimination of specific modifiable risk factors (alcohol abuse, smoking, environmental risk factors for falls, etc.) by means of regular physical activity and an adequate nutritional supply of calcium and vitamin D. Non-pharmacological interventions for the prevention and treatment of osteoporosis are recommended for all subjects
The therapeutic dilemma: how to use short-acting PDE5 inhibitor drugs
No full textIn the last few years, the clinical context of the diagnosis and treatment of erectile dysfunction (ED) has changed radically. In fact, oral drug treatment with phosphodiesterase type-5 inhibitors (PDE5-i), licensed in the past years, appeared to offer advantages over other medical approaches in terms of ease of administration and cost. PDE5-i are now widely advocated as first-line therapy for ED. PDE5-i represent a class of orally active drugs for ED, which inhibit PDE5 enzyme and in turn enhance smooth muscle relaxation via prolongation of cyclic GMP action within the cavernous smooth muscle. Although the various types of PDE5-i differ with respect to selectivity and pharmacokinetic profiles, efficacy and safety of these agents are mostly comparable in broad populations of men with erectile ED, including those with diabetes, cardiovascular disease or those taking multiple antihypertensive agents. Aim of this article will be to review the different efficacy and safety profiles of oral short-acting compounds and to give indication for treatment of special populations of men with ED
Special issue on materials development by additive manufacturing techniques
Full text linkAdditive manufacturing (AM) processes are steadily gaining attention from many industrial fields, as they are revolutionizing components' designs and production lines. However, the full application of these technologies to industrial manufacturing has to be supported by the study of the AM materials' properties and their correlations with the feedstock and the building conditions. Furthermore, nowadays, only a limited number of materials processable by AM are available on the market. It is, therefore, fundamental to widen the materials' portfolio and to study and develop new materials that can take advantage of these unique building processes. The present special issue collects recent research activities on these topics
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Edge piece on a lecture by Dr. Eugene Aversa, a veterinarian, about the healin
No full textEdge piece on a lecture by Dr. Eugene Aversa, a veterinarian, about the healing powers of raw pet food. The lecture is part of the series The Raw and the Cooked, and is being presented at Fetch in Portland May 23
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