100,324 research outputs found
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Urinary benzene and t,t-muconic acid as biomarkers of low level occupational exposure to benzene
No full textRischio dei principali sottotipi di linfoma associato all’uso di apparati di telefonia mobile
No full textINTRODUCTION: We explored the association between use of mobile phones and lymphoma risk in a case-control study. METHODS: We conducted unconditional logistic regression analysis in 322 lymphoma cases and 446 population controls, adjusting by age, gender and education.
RESULTS: Risk of lymphoma (all types; OR = 1.5; 95% CI 1.0 - 2.1), and chronic lymphocytic leukaemia (OR = 1.8; 95% CI 1.0 - 3.4) was elevated in subjects reporting use of mobile phones, but it decreased with duration of use, and years from first purchase.
CONCLUSIONS: Our contradictory findings would not support the aetiological nature of the observed associations
Is the persistence of isolated GH deficiency in adulthood predicted by anatomical hypothalamic-pituitary alterations?
No full textHandwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Urinary benzene and trans,trans-muconic acid excretion as biomakers of low level occupational exposure to benzene
No full textMisurament of urinary trans,trans muconic acid excretion is considered a reliable biomarker of occupational exposure to benzene.However at low level occupational and environmental exposure, an increased dietary intake of sorbic acid, a common anti-oxidant,can greatly reduce its specificity.Direct monitoring of urinary benzene requires technical prcautions and numerous non occipational sources of exposure might make it difficult using it as an indicator of low level occupational exposure.Within the Italian multicentre project on the " Effect of genetic polymorphisms and non occupational exposures on the inter-individual variability of biomarkers of exposure to benzene and PAH" cordinated nation-wide by the Clinica Devoto" of the University of Milan, we measured pre-shift and end-shift urinary excretion of benzene and t,t-MA in 33 oil refinery workers and 35 military fuel attendants of the Italian Air Forc
Urinary benzene and t,t-muconic acid excretion as biomarkers of low level occupational exposure to benzene
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