1,720,973 research outputs found
A Leydig Cell Tumour in a Cat: Histological and Immunohistochemical Findings
Full text linkA 13-year-old intact male cat was submitted to castration after the finding of the enlargement of the right testis during the clinical visit. Macroscopically, a nodule of 2 cm of diameter was observed on the cut surface of the enlarged testis. Histologically, the nodule was composed by polyhedral to elongated cells with a large, eosinophilic, and vacuolated cytoplasm and small, round, and dark nuclei. These cells were arranged in acinar structures and solid sheets. The tumour was diagnosed as a Leydig cell tumour. Immunohistochemical analysis revealed that neoplastic cells were vimentin, calretinin, and melan-A positive, whereas a lack of immunoreactivity to cytokeratins confirmed the diagnosis. To our knowledge, this is the first description of a feline Leydig cells tumour without any concurrent testicular neoplasm or in a nonretained testis
Immunohistochemical expression of COX-2, mPGES-1 and EP2 receptor in canine healthy and reactive bone tissues and in osteosarcomas.
No full textPTEN and E-Cadherin expression are associated in canine mammary tumours
Full text linklntroduction: PTEN is a tumor suppressor protein that negatively regulates tumor growth and invasiveness. Ecadherin
is a trans-membrane molecule known far its tumor invasion-suppressor role. In human medicine, it
has been hypnotized that the expression of these two proteins is correlated. The aim of this study is to
evaluate by immunohistochemistry if their expression is associated al so in canine mammary tumors.
Materials and Methods: Fifty-four canine mammary samples {15 hyperplasias, 7 adenomas and 32
carcinomas) were submitted to immunohistochemistry far the evaluation of PTEN and E-cadherin expression.
Subjects bearing mammary carcinoma were also submitted to a 2-year follow-up study to compare overall
survival with PTEN and E-cadherin expression.
Results: All the hyperplasias expressed both the markers, 100% of adenomas were positive far PTEN and 86%
far E-cadherin, and 69% and 34% of carcinomas were positive far PTEN and E-cadherin, respectively. PTEN and
E-cadherin expression was statistically correlated in ali the tumors (p <.01) and in the malignant ones (< .05).
The group positively-stained far the two markers correlated with a longer overall survival (< .05) and with the
absence of lymphatics invasion (<.05).Conclusions: Our results confirm the correlation between PTEN protein and E-cadherin expression and the
tu m or suppressor effect of this association in canine mammary tumors.
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
IMMUNOHISTOCHEMICAL EXPRESSION OF COX-2, MPGES-1 AND EP2 RECEPTOR IN HEALTHY AND REACTIVE CANINE BONE AND IN OSTEOSARCOMAS
No full textIntroduction: Accumulating evidence suggests that cyclooxygenase-2 (COX-2) is involved in growth, progression and metastasis of human osteosarcomas (OSs) and that its expression correlates with a poorer prognosis. The aim of this report was to study the expression of COX-2 in healthy, reactive, and neoplastic canine bone and to
investigate the events downstream to COX-2 that lead to PGE2 production by the evaluation of mPGES-1 and EP2 receptor expression.
Materials and Methods: COX-2, mPGES-1 and EP2 receptor expression were assessed by immunohistochemistry in 12 samples of normal bone, 14 reactive bones and 27 appendicular OSs. The
streptavidin-peroxidase method was used. The results were quantified according to previously described scores.
Results: In healthy tissues no immunoreactivity to COX-2, mPGES-1 and EP2 receptor was observed. Fifty percent of reactive bone samples
scored positive for COX-2 and 57% for mPGES-1 and EP2 receptor, although with a weak labelling intensity. Ninety-three percent of OSs expressed COX-2; mPGES-1 was expressed in 85% and EP2 receptor in 89% of tumours
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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