1,721,091 research outputs found
Response to Comments by Dr Gholami on “A Systematic Review of Iran’s Medicinal Plants With Anticancer Effects”
Get PDFAn overview of the most important medicinal plants affecting cardiac arrhythmia in Iran
Get PDFOxidative stress occur in several diseases such as cardiovascular disease, diabetes, cancer, aging and Alzheimer's disease. Cardiac arrhythmia is today a common clinical problem presenting with decrease, increase or mismatch in normal heart rhythm that cause reduction in cardiac output. Given the importance of heart diseases and noting that in many countries, cardiovascular diseases are among the top causes of death and the leading cause of disability and the fact that application of medicinal plants and herbal medicines is common in the treatment of hypertension, ischemic heart disease, congestive heart disease, arrhythmias and angina pectoralis, therefore, this review aimed to identify the anti-arrhythmic medicinal plants indigenous in Iran. Due to the proven anti-arrhythmic effects of medicinal herbs including grape, sour orange, olive, pokeweeds and nettle and regarding the obvious phytochemical agents in them, so hesperidin, naringin, deosepyn, apigenin, aloroporin and hydroxytyrosol, phytolactosin, catechins, betacianin, tannins and free phenolic acids can be used as anti-arrhythmic ingredients used for the production of bioactive agents
Hematopoietic medicinal plants based on ethnobotanical documents of Iran: A strategy to develop nature-based drugs effective on anemia
Get PDFAnemia is a very common public health problem which has recently been spread in both developed and developing countries. Anemia causes wanness, tachycardia, tinnitus, headache, irritability, weakness, and a number of nonspecific complaints. Many of the plants can be used as hematopoietic. This article is to report the medicinal plants that are used as hematopoietic according to the main references of the Iranian traditional medicine. For this purpose, the related articles were retrieved from the Web of Science, PubMed, Scopus, Islamic World Science Citation Center, and Magiran by the search terms consisting of anemia, hematopoietic, ethnobotany, medicinal plants, Iran, and traditional medicine. According to the findings of this study, Raphanus sativus, Oriyganum vulgare, Thymus vulgaris, Rosmarinus officinalis, Petroselinum crispum, Allium sativum, Foeniculum vulgare, Spinacia oleracea L., Phaseolus vulgaris, Prunus armeniaca, Matricaria chamomilla, Cucumis melo var.inodorus, Rheum officinale, Cucumis melo, Ficus carica, Citrus latifolia, Solanum tuberosum L., Ananas comosus, Solanum lycopersicum, Brassica rapa, Daucus carota, Urtica dioica, and Centaurea cyanus were found to be hematopoietic plants. These plants contain bioactive and antioxidant components that either have iron or affect the body's mechanisms and cause hematopoiesis
Atherosclerosis: Pathophysiology and promising herbal remedies in traditional Persian medicine
Get PDFAtherosclerosis is a progressive inflammatory disease and is considered as main reason of death and morbidity in worldwide. The common drugs which are used for treatment of atherosclerosis reveal side effects, therefore it is necessary to identify the natural sources. This study overviews the pathophysiology of atherosclerosis and effective medicinal plants present in Iran. In this study, 19 medical plants have been reported to be scientifically effective against atherosclerosis which are included Punica granatum L., Aloe vera, Amaranthus caudatus L., Artemisia sieberi Besser, Artemisia spp., Rhus coriaria, Nigella sativa L., Trifolium pratense L., Anethum graveolens, Glycyrrhiza glabra, Vaccinium myrtillus L, Gundelia tournefortii L, Hypericum perforatum, Curcuma longa, Crocus sativus L, Malus domestica, Silybum marianum, Berberis integerrima and Portulaca oleracea L. These plants have antioxidant and flavonoid compounds with unknown mechanisms serve to improve atherosclerosis. It seems that medicinal plants native to Iran, which have antioxidant and inhibit the oxidative stress, reduce inflammatory processes and ultimately improve atherosclerosis
The chemical composition, botanical characteristic and biological activities of Borago officinalis: a review
Get PDFAbstractBorage (Borago officinalis) is an annual herb which is cultivated for medicinal and culinary uses, although it is commercially cultivated for borage seed oil. Borage seed oil is the plant rich in the gamma-linolenic acid (26%-38%) which is used as dietary or food supplement. Other than seed oil it contains a lot of fatty acids such as linoleic acid (35%-38%), oleic acid (16%-20%), palmitic acid (10%-11%), stearic acid (3.5%-4.5%), eicosenoic acid (3.5%-5.5%) and erucic acid (1.5%-3.5%). It is used for the treatment of various diseases such as multiple sclerosis, diabetes, heart diseases, arthritis and eczema. In this study different aspects of borage such as plant characteristics, production, applications in traditional medicine, clinical considerations, its effects on patients' blood and urine biochemistry, and also the effect of the its products on liver and kidney performance tests are presented using published articles in scientific sites
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The effect of feeding with soybean on serum levels of TSH, T3 and T4 in male mice
Get PDFIntroduction: Soybean possesses isoflavones and might, therefore, cause problem in thyroid hormone synthesis. The purpose of this study was to study the effect of soybean on serum levels of Thyroid stimulating hormone (TSH), Triiodothyronine (T3), and Thyroxine (T4) in male mice. Methods: In this experimental study, 24 Balb/C male mice were randomly assigned to three groups of eight including control or base diet-fed group and treatment groups 1 and 2 receiving respectively 30 and 50 soybean-containing diet. After nine weeks, the blood sample was taken from the animals’ heart and serum levels of TSH, T3, and T4 were measured. The data were analyzed by SPSS software using one-way ANOVA and Duncan’s test. Results: In 50 soybean group, a significant decrease was observed in T4 serum level compared to the control group (p<0.05). On the other hand, this hormone level non-significantly decreased in the group fed by 30 soybean compared to the control group (p<0.05). TSH serum level increased significantly in 30 soybean group compared to the control group (p<0.05). But, serum level of T3 was not significantly different between 30 or 50 soybean groups and control group (p>0.05). Conclusion: In view of the findings, it is estimated that the effect of addition of soybean into meal on thyroid function is dose-dependent, so that the diet containing 30 and 50 soybean might cause increased TSH release in thyrotrope cells and hence variation in pituitary-thyroid axis function.</p
Antiepileptic activity of hydroalcoholic extract of basil in mice
Get PDFIntroduction: Epilepsy has been always considered as one of the most prevalent disorders of nervous system and despite various drugs available, there are still some patients who have drug resistance. In traditional medicine, basil (Ocimum basilicum) has been used in treating epilepsy. To achieve an effective antiepileptic drug with few side effects, the antiepileptic effect of O. basilicum was investigated in pentylenetetrazole (PTZ)-induced epilepsy model. Methods: In this experimental research, 48 laboratory female mice (for removing gender factor) were designated in 6 equal groups. The experimental groups comprised control, sham, and four treatment groups receiving the extract at 100, 250, 300, and 350 mg/kg doses (intraperitoneally; ip), 65 minutes before PTZ injection and the factors of epilepsy symptoms and the symptoms frequency were studied. Results: The obtained results of using different doses (100, 250, 300, 350 mg/kg) of the extract indicated that the mice in 100 mg/kg dose group exhibited the highest frequency of epileptic attacks. The samples receiving the extract at 100 and 250 mg/kg doses exhibited the highest and lowest frequency of myoclonic twitches, respectively. In the group treated with 250 mg/kg dose, the symptoms of epilepsy, frequency of epilepsy, and mortality rate respectively increased, decreased, and decreased (p<0.05). Conclusion: By the obtained results, the hydroalcoholic extract of O. basilicum at 250 mg/kg dose could be recommended as an effective drug for preventing epilepsy in the animal model.</p
Modulation of MicroRNAs by Euphorbia microsciadia Boiss in MDA-MB-231: New Possibilities in Breast Cancer Therapy
No full textBackground: A large number of Euphorbia species have been evaluated for anticancer effects; however, their anticancer mechanisms have not been established up to now.
Objective: The present study aimed to evaluate the effects of Euphorbia microsciadia (E. microsciadia) Boiss on the modulation of micro (mi) RNAs in MDA-MB-231 cell line.
Methods: As the first step, inhibitory concentration of hydroalcoholic extract of E. microsciadia on MDA-MB-231 cells was examined using the MTT assay, by passing 24 and 48h from seeding. The real-time quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR) was also utilized to determine Let-7, miR-15, miR-16, miR-29, miR-151, miR-155, miR-21, miR-146b, miR-181b, miR-221, miR-222, miR-21, and miR-146b expressions in MDA-MB-231 cells, by passing 24 and 48h from treating with the extract of E. microsciadia.
Results: The results reveal the cytotoxic effects of E. microsciadia on MDA-MB-231 cell line in a dose-dependent manner. The half maximal Inhibitory Concentrations (IC50) were also equal to 275 and 240μg/ml for E. microsciadia, by passing 24 and 48h from the treatment, respectively. Furthermore, it was confirmed that, E. microsciadia had augmented the expression levels of Let-7, miR-15, miR-16, miR-29, and miR-34a, which lead to an increase in apoptosis.
Conclusion: E. microsciadia could modulate some miRNAs involved in cell cycle arrest and apoptosis in MDA-MB-231 cell line. Accordingly, targeting miRNAs by E. microsciadia can open some newer avenues for breast cancer therapy.
Keywords: Apoptosis; breast cancer; cell cycle; euphorbia; miR-34a; microRNA; tumor suppressor.
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