1,721,198 research outputs found
Sulle orme di Vincenzo de' Paoli. Jeanne-Antide Thouret e le Suore della Carità dalla Francia rivoluzionaria alla Napoli della Restaurazione
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Mitochondrial ferritin
No full textA novel ferritin type specifically targeted to mitochondria has been recently found in human and mouse. It is structurally and functionally similar to the cytosolic ferritins, well-characterized molecules found in most living systems which are designed to store and detoxify cellular iron. Cytosolic ferritins in mammals are ubiquitous while mitochondrial ferritin expression is restricted mainly to the testis, neuronal cells and islets of Langherans. In addition, it is abundant in the iron-loaded mitochondria of erythroblasts of patients with sideroblastic anaemia. The characterization of recombinant and transfected mitochondrial ferritin indicated that this protein has a role in protecting mitochondria from iron-induced damage. These data suggest that it is an interesting tool to study the iron metabolism in this organelle. In addition, it may be useful for the diagnosis of myelodysplastic syndromes and in protecting mitochondria from the toxic effects of excess iron. © 2003 Elsevier Ltd. All rights reserved
Mechanistic modelling of avascular tumor growth and pharmacokinetics influence—Part I
No full textA mechanistic model for the avascular tumor growth both for in “in vivo” and “in vitro” conditions is presented here. It involves the main
cell physiology, like the growth (by substrate uptake), the mitosis, the apoptosis and the necrosis, all with their corresponding kinetics. The
resulting population balance was solved through the moments’ method. Moreover, the model was combined with the classic equations of
pharmacokinetics to consider also the presence of active drugs affecting either the kinetics of cell necrosis or growth. The model was compared
with literature tumor growth data both for in vivo and in vitro conditions
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Manipulations of cellular iron metabolism for modulating normal and malignant cell proliferation: achievements and prospects.
No full textAnalysis of the role of iron in cell proliferation, and of manipulations of cellular iron metabolism for modulating normal and malignant cell proliferatio
Iron detoxifying activity of ferritin. Effects of H and L human apoferritins on lipid peroxidation in vitro.
No full textThe ancestral hemochromatosis haplotype is associated with a severe phenotype expression in italian patients
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