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Studio comparativo tra la cromatografia ad alta pressione e l'elettroforesi capillare per la simultanea determinazione di allantoina, acido urico, ipoxantina e xantina in placche ateromasiche. A comparative study of simultaneous determination by capillary zone electrophoresis and high performance liquid chromatography of allantoin, uric acid, hypoxanthine and xanthine in atherosclerotic plaque.
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Determinazione dell’acido urico nelle placche carotidee: possibile mediatore dell’ aterosclerosi? Determination of uric acid in carotid artery plaque:a possible mediator of atherosclerosis?
No full textBackground. In this work we determined uric acid (UA), an antioxidant that enhances in oxidative stress, in atheromatous plaque, characterized by this phenomenon, to improve our knowledge of oxidative stress and to show a possible correlation between biochemical and ultrasonographic plaque characterization. We have also analyzed UA in the plasma of the same subjects to show a possible correlation between plasma and plaque UA levels. This could help us to study plaque evolution. Methods. Surgical specimens and plasma were obtained from patients (symptomatic and asymptomatic) undergoing carotid endoarterectomy. Plaque was characterized by duplex scan. UA was determined by high performance liquid chromatography (HPLC). Results. Concentrations of UA were much lower in plaque (10.3±2.2 μg/g) than in plasma (48.7±2.4 μg/ml). There was no correlation between UA plasma levels and UA in plaque. There were no differences of UA in the different groups analyzed. Conclusions. UA seems to have a direct role in atherosclerosis. The absence of correlation between UA plasma level and UA in plaque should confirm that UA in plaque is not due to accumulation from plasma, but a local intrinsic phenomenon of intimal disease space. Actually, it is impossible, considering the restricted case number, to say that UA plasma levels can help in the study of plaque evolution
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Purine nucleotide catabolism in rat liver. Labelling of uric acid and allantoin after treatment with oxonic acid and allopurinol
No full textIn our previous experiments on rat liver we found that 15' after intraperitoneal administration of 14C-formate the specific radioactivity of allantoin was always higher than that of uric acid. The present experiments have been carried out to interpret this unexpected result, which was only observed in liver and we studied: a) the incorporation of 14C-glycine into uric acid and allantoin; b) the effects of two competitive inhibitors of xanthine oxidase and uricase, oxonic acid and allopurinol respectively, on levels of uric acid and allantoin in liver and on their specific radioactivity after administration of labelled precursor. The results suggested: a) that under normal conditions, the formation of allantoin is so fast that it exceedes export from liver to serum, and thus the radioactivity of labelled precursors accumulates in allantoin; b) that when allopurinol or oxonic acid are administered, the rate of export exceeds that of allantoin formation and the incorporation of radioactivity into allantoin is lower; c) that not all the data, however, could be interpreted on this basis, but seems to require the existence of different pools of uric acid, which are transformed separately into allantoi
Levels of folic acid in plasma and in blood cells of colorectal cancer patients
No full textThe levels of folic acid have been determined by radioimmunological method in the plasma and in the red blood cells of normal subjects and colorectal cancer patients. A decrease was evident both in the plasma and erythrocytes of cancer patients. The possible reasons and applications of this observation are discusse
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Determination of Vascular Endothelium Growth Factor by Elisa Test and comparison with Western Blot
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