1,721,051 research outputs found
The enzimatic oxidation products of spermine induce differential cytotoxic effect on wild type and drug-resistant colon carcinoma cells.
No full textDifferential cytotoxic effect of spermine enzymatic oxidation products on wild type and drug-resistant human colon carcinoma cell lines.
No full textThe enzymatic oxidation products of spermine induce cytotoxicity on human colon adenocarcinoma cells.
No full textStructural and functional alterations of cellular components as revealed by electron microscopy.
No full text"Scanning (SEM) and transmission electron microscopy (TEM) are two fundamental microscopic techniques widely applied in biological research for the study of ultrastructural cell components. With these methods, especially TEM, it is possible to detect and quantify the morphological and ultrastructural parameters of intracellular organelles (mitochondria, Golgi apparatus, lysosomes, peroxisomes, endosomes, endoplasmic reticulum, cytoskeleton, nucleus, etc.) in normal and pathological conditions. The study of intracellular vesicle compartmentalization is raising even more interest in the light of the importance of intracellular localization of mediators of the signaling in eliciting different biological responses. The study of the morphology of some intracellular organelles can supply information on the bio-energetic status of the cells. TEM has also a pivotal role in the determination of different types of programmed cell death. In fact, the visualization of autophagosomes and autophagolysosomes is essential to determine the occurrence of autophagy (and also to discriminate micro-autophagy from macro-autophagy), while the presence of fragmented nuclei and surface blebbing is characteristic of apoptosis. SEM is particularly useful for the study of the morphological features of the cells and, therefore, can shed light, for instance, on cell-cell interactions. After a brief introduction on the basic principles of the main electron microscopy methods, the article describes some cell components with the aim to demonstrate the huge role of the ultrastructural analysis played in the knowledge of the relationship between function and structure of the biological objects
Cytotoxicity induced by oxidation products of spermine in sensitive and drug-resistant colon adenocarcinoma cells.
No full textMDL 72527 POTENTIATES CELL DEATH INDUCED BY SPERMINE OXIDATION PRODUCTS ON HUMAN CANCER CELLS
No full textThe enzymatic oxidation products of spermine induce higher cytotoxic effects on multidrug resistant colon carcinoma cells (LoVo) than on their wild type counterparts
No full text2nd International joint meeting: "In vitro models and toxicity mechanism", Verona, May 30 - June 1, 200
A MODIFIED SPECTROSCOPIC METHOD FOR THE DETERMINATION OF THE TRANSBILAYER DISTRIBUTION OF PHOSPHATIDYLETHANOLAMINE IN SOYBEAN ASOLECTIN SMALL UNILAMELLAR VESICLES
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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