1,721,184 research outputs found
Le piante velenose della Sardegna
No full textIl volume vuole essere un presidio per coloro che si occupano di allevamento zootecnico ed in particolare una facile guida per il riconoscimento delle specie tossiche capaci di interferire sulla salute degli animal
Euphorbium: modern research on its active principle, resiniferatoxin, revives an ancient medicine
No full textResiniferatoxin, an ultrapotent capsaicin analog present in the latex of Euphorbia resinifera, interacts at a specific membrane recognition site (referred to as the vanilloid receptor), expressed by primary sensory neurons mediating pain perception as well as neurogenic inflammation. Desensitization to resiniferatoxin is a promising approach to mitigate neuropathic pain and other pathological conditions in which sensory neuropeptides released from capsaicin-sensitive neurons play a crucial role. Clinical trials to evaluate the potential of topical resiniferatoxin treatment to relieve pain associated with diabetic polyneuropathy and postherpetic neuralgia are in progress. Though resiniferatoxin was isolated only two decades ago, the dried latex of Euphorbia resinifera, called Euphorbium, has been in medicinal use since the time of recorded history. This review highlights the most important events in the history of this ancient medicine, from the first written record of the therapeutic potential of Euphorbium (at the time of the reign of the Roman Emperor Augustus) to the identification of its active principle as resiniferatoxin in 1975. A brief overview of the enormous contribution of resiniferatoxin to our current understanding of the anatomical localization, function, and pharmacology of vanilloid receptors is provided. Lastly, the mechanisms are summarized by which capsaicin and resiniferatoxin, despite sharing receptors, may have dissimilar biological actions
The chemistry and occurrence of taxane derivatives. XXXI. Unusual reactivity of taxine A in an oxidation-reduction protocol
No full textRecreational drug discovery: natural products as lead structures for the synthesis of smart drugs
No full textOver the past decade, there has been a growing transition in recreational drugs from natural materials (marijuana, hashish, opium), natural products (morphine, cocaine), or their simple derivatives (heroin), to synthetic agents more potent than natural prototypes, sometimes less harmful in the short term, or that combine properties from different classes of recreational prototypes. These agents have been named smart drugs, and have become popular both for personal consumption and for collective intoxication in rave parties. The reasons for this transition are various, but mainly regulatory and commercial. New analogues of known illegal intoxicants are invisible to most forensic detection techniques, while the alleged natural status and the lack of avert acute toxicity make them appealing to a wide range of users. On the other hand, the advent of internet has made it possible the quick dispersal of information among users and the on-line purchase of these agents and/or the precursors for their synthesis. Unlike their natural products chemotypes (ephedrine, mescaline, cathinone, psilocybin, THC), most new drugs of abuse are largely unfamiliar to the organic chemistry community as well as to the health care providers. To raise awareness in the growing plague of smart drugs we have surveyed, in a medicinal chemistry fashion, their development from natural products leads, their current methods of production, and the role that clandestine home laboratories and underground chemists have played in the surge of popularity of these drugs
Resurrecting The Cornforth Model for Carbonyl Addition: Studies on the Origin of the 1,2-Asymmetric Induction in Enolate Addition to Heteroatom-Substituted Aldehydes.
No full textMacrocyclic diterpenoids from Euphorbia hyberna L. subsp insularis and their reaction with oxyphilic reagents
No full textRETRACTED: Cannabidiol (CBD) From Non-Cannabis Plants: Myth or Reality?
No full textReports on the occurrence of cannabidiol (CBD, 1) in non-cannabis plants are critically reviewed. The isolation of 1 from Humulus Kriya (sic) was fraudulent and from Trema orientalis and stevia dubious, while the occurrence of traces of 1 in flax needs additional confirmation. The presence of high concentration of cannabigerol (CBG, 3a) and its corresponding acidic precursor (GBGA, 3b) in Helichrysum umbraculigerum could not be confirmed, but this plant deserves additional attention due to the possible phytocannabinoids accumulation in selected chemotypes
Polyoxygenated eudesmanes and chrysanthemanes from the aerial parts of Santolina insularis
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