1,721,257 research outputs found
The Y682ENPTY687 motif of APP: Progress and insights toward a targeted therapy for Alzheimer's disease patients
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Human ether-a-gogo related gene (HERG) K+ channels as pharmacological targets: present and future implications.
No full textModulation of the K(+) channels encoded by the human ether-a-gogo-related gene-1 (hERG1) by nitric oxide
Full text linkInhibition of HERG1 K(+) channels by the novel second-generation antihistamine mizolastine.
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Inhibition of HERG1 K(+) channels by the novel second-generation antihistamine mizolastine.
No full textNew perspectives for selective NCX activators in neurodegenerative diseases
No full textThe Na+/Ca2+ exchanger plays a relevant role in several neurological disorders, thus the pharmacological modulation of its isoforms might represent a promising strategy to ameliorate the course of some neurological pathologies including stroke, neonatal hypoxia, multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer Disease (AD), and spinal muscular atrophy (SMA). This review will summarize heterocyclic, peptidergic, genetic and epigenetic compounds activating or inhibiting the expression/activity of each NCX isoform. In addition, we will focus our attention on the development of new strategies aimed to ameliorate the pathophysiological conditions in which NCX isoform changes are found
Human ether-a-gogo related gene (HERG) K+ channels as pharmacological targets: present and future implications.
No full textHistidines 578 and 587 in the S5-S6 linker of the human Ether-a-gogo Related Gene-1 K+ channels confer sensitivity to reactive oxygen species
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