1,701 research outputs found
Trasmissible Spongiform Encephalopathies
No full textProtein folding and misfolding, relevance to disease and function / Massimi Stefani --
Alzheimer's disease / Charlotte E. Teunissen and Tischa M. van der Cammen --
Improving Cholinergic Transmission --
Cholinergic transmission and acetylcholine release enhancers / Pierre Francotte, Pascal de Tullio and Bernard Pirotte --
AChE and its inhibition / Jure Stojan --
AChE inhibitors and their clinical assessment / Pierre Francotte, Pascal de Tullio and Bernard Pirotte --
Reduction in plaque formation / Christian Czech, Helmut Jacobsen and Celine Adessi --
Non-steroidal anti-inflammatory drugs (NSAIDs) / Bruno P. Imbimbo and Francesca Speroni --
3-hydroxy-3-methyl-glutaryl-coenzyme reductase inhibitors / Dario Cattaneo --
A' polymerization reduction / Harry LeVine III and Corrine E. Augelli-Szafran --
Carbonic anhydrase activators as potential anti-Alzheimer's disease agents / Claudiu T. Supuran and Andrea Scozzafava --
Detection and reduction of neurofibrillary lesions / Jeff Kuret --
Protein misfolding in Alzheimer disease : pathogenic or protective? / Rudy J. Castellani ... [et al.] --
Enhancement of brain retinoic acid levels / Ann B. Goodman ... [et al.] --
Parkinson's disease : what is it? what causes it? and how can it be cured? / Tom Foltynie, Andrew W. Michell and Roger A. Barker --
Restoring dopamine levels / Nuno Palma .. [et al.] --
Huntington's disease / Claire-Anne Gutekunst and Fran Norflus --
Amyotrophic lateral sclerosis (motor neuron disease) / Teresa Sanelli ... [et al.] --
Transmissible spongiform encephalopathies (TSEs) / Michael D. Geschwind and Giuseppe Legname --
Overview / H. John Smith, Claire Simons and Robert D.E. Sewell
Figure 3. A, B in Molecules, morphology, missing data and the phylogenetic position of a recently extinct madtom catfish (Actinopterygii: Ictaluridae)
No full textFigure 3. A, B, pectoral girdle, ventral view, anterior at top. A, Noturus munitus, JFBM 43107; B, N. funebris, JFBM 43002. C–E, posttemporo-supracleithrum, posterior view, anterior into page. C, N. munitus, JFBM 43107; D, N. eleutherus, JFBM 43055; E, N. funebris, JFBM 43002. cl = cleithrum; pr = pectoral radial; ps = pectoral fin spine; sco = scapulo-coracoid. Numbers refer to characters and states listed in Appendix S2. Cartilage shown by grey shading. Scale bar = 1 mm.Published as part of Egge, Jacob J. D. & Simons, Andrew M., 2009, Molecules, morphology, missing data and the phylogenetic position of a recently extinct madtom catfish (Actinopterygii: Ictaluridae), pp. 60-75 in Zoological Journal of the Linnean Society 155 (1) on page 65, DOI: 10.1111/j.1096-3642.2008.00432.x, http://zenodo.org/record/544580
Systematics of the combtooth blenny clade Omobranchus (Blenniidae: Omobranchini), with notes on early life history stages
No full textGibbs, Sean, Hundt, Peter J., Nelson, Andrea, Egan, Joshua P., Tongnunui, Prasert, Simons, Andrew M. (2018): Systematics of the combtooth blenny clade Omobranchus (Blenniidae: Omobranchini), with notes on early life history stages. Zootaxa 4369 (2): 270-280, DOI: 10.11646/zootaxa.4369.2.
Aspects of supersymmetry in multiple membrane theories
No full textPhDThis thesis consists of two parts. In the rst part we investigate the worldvolume
supersymmetry algebra of multiple membrane theories. We begin with a description
of M-theory branes and their intersections from the perspective of spacetime
and worldvolume supersymmetry algebras. We then provide an overview of the
recent work on multiple M2-branes focusing on the Bagger-Lambert theory and
its relation to the Nambu-Poisson M5-brane and the ABJM theory. The worldvolume
supersymmetry algebras of these theories are explicitly calculated and the
charges interpreted in terms of spacetime intersections of M-branes.
The second part of the thesis looks at l3
p corrections to the supersymmetry
transformations of the Bagger-Lambert theory. We begin with a review of the
dNS duality transformation which allows a gauge eld to be dualised to a scalar
eld in 2+1 dimensions. Applying this duality to 02 terms of the non-abelian
D2-brane theory gives rise to the l3
p corrections of the Lorentzian Bagger-Lambert
theory. We then apply this duality transformation to the 02 corrections of the
D2-brane supersymmetry transformations. For the `abelian' Bagger-Lambert theory
we are able to uniquely determine the l3
p corrections to the supersymmetry
transformations of the scalar and fermion elds. Generalising to the `non-abelian'
Bagger-Lambert theory we are able to determine the l3
p correction to the supersymmetry
transformation of the fermion eld. Along the way make a number of
observations relating to the implementation of the dNS duality transformation at
the level of supersymmetry transformations
UNUSUAL NEGATIVE MOLECULAR IONS AND DIANIONS AND CHEMICAL BONDS INVOLVING RYDBERG ORBITALS
No full text1. Maciej Gutowski, Piotr Skurski, Kenneth D. Jordan, Jack Simons; Int J. Quant. Chem.; 64, 183 (1997). 2. P. Skurski, M. Gutowski and J. Simons, Int J. Quant Chem. 76. 197 (2000). 3. Alexander I. Boldyrev, Maciej Gutowski, and Jack Simons; Acc. Chem. Res.; 29, 497 (1996). 4. Jack Simons and Maciej Gutowski, Chem. Rev. 91, 669 (1991). 5. A. I. Boldyrev and J. Simons; J. Phys. Chem. 96, 8840 (1992); A. I. Boldyrev and J. Simons. J. Phys. Chem., 103, 3575 (1999).Author Institution: Department of Chemistry and Henry Eyring Center for Theoretical Chemistry, University of UtahIn this presentation, our work and that of several other groups on the species listed in the title will be discussed. Particular emphasis will be given to: (a) dipole bound (which have also been the subject of numerous experimental studies), (b) dipole bound (which remain theoretical speculation), (c) resonance states of anions that can be made stable via ``solvation'', (d) dianions such as that have extremely high second electron binding (which occur in the solid state and in solution), (e) anions in which the ``extra'' electron occupies a Rydberg-like molecular (which have been seen experimentally), and (f) chemical bonds that arise when a Rydberg-like orbital is
ABJ(M) Chiral Primary Three-Point Function at Two-loops
No full textThis article is distributed under the terms of the Creative Commons
Attribution License (CC-BY 4.0), which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.archiveprefix: arXiv primaryclass: hep-th reportnumber: QMUL-PH-14-10 slaccitation: %%CITATION = ARXIV:1404.1117;%%archiveprefix: arXiv primaryclass: hep-th reportnumber: QMUL-PH-14-10 slaccitation: %%CITATION = ARXIV:1404.1117;%%archiveprefix: arXiv primaryclass: hep-th reportnumber: QMUL-PH-14-10 slaccitation: %%CITATION = ARXIV:1404.1117;%%Article funded by SCOAP
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A probabilistic assessment of sea level variations within the Last Interglacial stage
No full textThe Last Interglacial (LIG) stage (ca. 130–115 ka) provides a relatively recent example of a world with both poles characterized by greater-than- Holocene temperatures similar to those expected later in this century under a range of greenhouse gas emission scenarios. Previous analyses inferred that LIG mean global sea level (GSL) peaked 6–9 m higher than today (Kopp et al. 2009; Dutton & Lambeck 2012). Here, we extend our earlier work to perform a probabilistic assessment of sea level variability within the LIG highstand. Using the terminology for probability employed in the Intergovernmental Panel on Climate Change (IPCC) assessment reports, we find it extremely likely (95% probability) that the paleo-sea level record allows resolution of at least two intra-LIG sea level peaks and likely (67% probability) that the magnitude of low-to-high swings exceeded 4 m. Moreover, it is likely that there was a period during the LIG in which GSL rose at a 1000-year average rate exceeding 3 m/ky, but unlikely (33% probability) that the rate exceeded 7 m/ky and extremely unlikely (5% probability) that it exceeded 11 m/ky. These rate estimates can provide insight into rates of Greenland and/or Antarctic melt under climate conditions partially analogous to those expected in the twenty- first century.This is the authors’ preprint version of the manuscript: 23 January 2013. Originally submitted 18 September 2012. Accepted for publication in Geophysical Journal International, published by Oxford University Press.Peer reviewe
The Simons Observatory: Astro2020 Decadal Project Whitepaper
No full textInternational audienceThe Simons Observatory (SO) is a ground-based cosmic microwave background (CMB) experiment sited on Cerro Toco in the Atacama Desert in Chile that promises to provide breakthrough discoveries in fundamental physics, cosmology, and astrophysics. Supported by the Simons Foundation, the Heising-Simons Foundation, and with contributions from collaborating institutions, SO will see first light in 2021 and start a five year survey in 2022. SO has 287 collaborators from 12 countries and 53 institutions, including 85 students and 90 postdocs. The SO experiment in its currently funded form ('SO-Nominal') consists of three 0.4 m Small Aperture Telescopes (SATs) and one 6 m Large Aperture Telescope (LAT). Optimized for minimizing systematic errors in polarization measurements at large angular scales, the SATs will perform a deep, degree-scale survey of 10% of the sky to search for the signature of primordial gravitational waves. The LAT will survey 40% of the sky with arc-minute resolution. These observations will measure (or limit) the sum of neutrino masses, search for light relics, measure the early behavior of Dark Energy, and refine our understanding of the intergalactic medium, clusters and the role of feedback in galaxy formation. With up to ten times the sensitivity and five times the angular resolution of the Planck satellite, and roughly an order of magnitude increase in mapping speed over currently operating ("Stage 3") experiments, SO will measure the CMB temperature and polarization fluctuations to exquisite precision in six frequency bands from 27 to 280 GHz. SO will rapidly advance CMB science while informing the design of future observatories such as CMB-S4
Temperature Dependence on Domain Switching Behavior in Lead Zirconate Titanate Under Electrical Load via In Situ Neutron Diffraction
No full textThe influence of temperature on the kinetics of domain switching in lead zirconate titanate was investigated by using in situ neutron diffraction. Samples were electrically loaded to 1 kV/mm at 30°C, 125°C, and 175°C, after which the diffracted patterns in the on- and off-state were compared. The results demonstrated that the degree of domain switching increases with increased temperature. Corroboration with hysteresis measurements showed that while the coercive field decreases withincreasing temperature, the degree of saturation increased significantly. According to Merz’s model, it is therefore apparent that, due to increased switching rate at high temperature, domain switchability increases with temperature
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