1,721,052 research outputs found

    Effect of diphtheria toxin on isolated perfused liver in vitro: preliminary observations

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    The effect of diphtheria toxin on liver cell cytoplasm and mitochondria was evaluated by studying the release of malic dehydrogenase (MDH), glutamic pyruvic transaminase (GTP), and glutamic dehydrogenase (GLDH) enzyme activities from the isolated rat or guinea pig liver treated with toxin. Perfusions were prolonged for 6 hours after the addition of the toxin to the medium: 500 guinea pig MLD for rat liver perfusion, 1 guinea pig MLD for guinea pig liver perfusion. For both animal species MDH, GPT and GLDH values in perfusate samples of toxin experiments did not differ significantly from their control experiments. (25 references.

    Visceral leishmaniasis during pregnancy treated with meglumine antimoniate.

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    Data on the efficacy and safety of pentavalent antimony in the treatment of visceral leishmaniasis during pregnancy are scanty. A case of visceral leishmaniasis in a 39-year-old woman in the second trimester of pregnancy is reported here. The patient was hospitalized in poor condition with high fever and pancytopenia which had lasted for 6 weeks. A bone marrow aspirate revealed numerous amastigotes and serodiagnosis for Leishmania was positive at a high titer. The patient was successfully treated with meglumine antimoniate at a daily dose of 850 mg of antimony for 20 days. She delivered at term a healthy female baby who remains in good condition at 18 months of age. Thus a dose of 850 mg of antimony, which is lower than that presently recommended, seems to be effective and non toxic to the fetus when administered at the second trimester of pregnancy

    Visceral leishmaniasis during pregnancy treated with meglumine antimoniate

    No full text
    Data on the efficacy and safety of pentavalent antimony in the treatment of visceral leishmaniasis during pregnancy are scanty. A case of visceral leishmaniasis in a 39-year-old woman in the second trimester of pregnancy is reported here. The patient was hospitalized in poor condition with high fever and pancytopenia which had lasted for 6 weeks. A bone marrow aspirate revealed numerous amastigotes and serodiagnosis for Leishmania was positive at a high titer. The patient was successfully treated with meglumine anti-moniate at a daily dose of 850 mg of antimony for 20 days. She delivered at term a healthy female baby who remains in good condition at 18 months of age. Thus a dose of 850 mg of antimony, which is lower than that presently recommended, seems to be effective and non toxic to the fetus when administered at the second trimester of pregnancy. © 1995 MMV Medizin Verlag GmbH
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