1,721,030 research outputs found
Nicotinamide decreases MHC class II but not MHC class I expression and increases intercellular adhesion molecule-1 structures in non-obese diabetic mouse pancreas
No full text
Multiple low-dose and single high-dose treatments with streptozotocin do not generate nitric oxide
No full textIs heart rate variability a valid parameter to predict sudden death in patients with Becker's muscular dystrophy?
No full textCytokine regulatory effects on alpha-1 proteinase inhibitor expression in NOD mouse islet endothelial cells
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Clinical and electrodiagnostic follow-up of an adolescent poisoned with thallium.
No full textWe report a six-year clinical and electrodiagnos-tic follow-up of an adolescent patient with acute thallium
poisoning from attempted suicide. During the acute stage
the patient showed gastrointestinal disturbances, alopecia,
and clinical and electrodiagnostic signs of severe polyneu-ropathy. Three years after poisoning, his neurological
symptomatology was making progress, and electrophysio-logic signs of peripheral neuropathy were mainly confined
to lower limbs. Six years after intoxication, he was still
complaining of weakness and sensory disturbances at the
level of distal lower extremities; his neurologic and elec-trodiagnostic abnormalities affected mainly the feet. In this
case report we underline the importance of early diagnosis
and treatment to prevent neurological damage and the role
of serial electromyographic and nerve conduction studies
in thallium poisoning. These investigations allowed the
authors to depict the electrophysiologic course of peripher-al nervous system involvement over six years following
poisonin
Cytokine regulatory effects on α-1 proteinase inhibitor expression in NOD mouse islet endothelial cells
No full textHuman microvascular islet endothelial cells (IEC) exhibit specific morphological and functional characteristics that differ from endothelia derived from other organs. One of these characteristics is the expression of alpha-1 proteinase inhibitor (Api). In this study, we observed its expression in nonobese diabetic (NOD) mouse IEC, in relation to the occurrence of type 1 diabetes and in response to cytokines, namely IL-1beta and IL-10. In addition, IL-10-deficient NOD mice as well as IL-10 transgenic NODs were studied. Results have demonstrated that Api expression is: (i) highly specific for IEC in NOD mouse islets, as for humans; (ii) linked to the occurrence of early type 1 diabetes, and iii) strongly modulated by Th1 and Th2 cytokines. In fact, Api mRNA found in pre-diabetic NOD animals is significantly reduced when they become hyperglycemic and disappears by 25 weeks of age, when mice are diabetic. Moreover, Api mRNAs are never seen in nondiabetic controls. Furthermore, in cultured NOD IEC, Api expression is downregulated by the addition of IL-1beta and is upregulated by IL-10; it is always absent in IL-10-deficient NOD mice and overexpressed in IL-10 transgenic NODs, thus further supporting that this cytokine upregulates Api expression. (C) 2002 Wiley-Liss, Inc
Air entrapment as a cause of early inappropriate shocks after subcutaneous defibrillator implant: A case series
No full textInappropriate shock (IAS) is the most frequent device-related complication among patients with subcutaneous implantable cardioverter-defibrillator (S-ICD). Air entrapment (AE) has been described as an underdiagnosed cause of early postimplant IAS. We report 6 consecutive cases of early IAS after S-ICD implant, in whom the electrogram analysis (EGM) and/or chest radiography (CXR) were consistent with AE
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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