1,721,110 research outputs found

    Assessment of the risk of pollution from Arsenic on human health as a function of its speciation in intestinal fluids.

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    ABSTRACT Investigating the risk on human health arising from exposure to As-polluted drinking water is a very important task since many area of the world has to face with this problem. Actually, chronic poisoning by arsenic carried by water has been well documented in many European and extra-European countries. Pollution of water with arsenic develops generalized symptoms of poisoning and carcinogenesis. It is well known that inorganic As is rapidly absorbed after oral exposure, but little information is still available about the fate of arsenic after oral ingestion. In particular, the mechanism which affects the speciation of this element in the gastrointestinal tract is not clear, especially when other trace elements are present. In this paper we present an estimate of the health risk due to the ingestion of water containing micro-pollutants, such as As and B, using two computational codes: PHREEQC, which allowed us to determine the effect of boron on arsenic speciation in equilibrium with the fluids of the gastrointestinal tract; SADA software for assessing the risk of exposure to contaminated matrices. The use of software in the present case study is mandatory since it is quite impossible to obtain experimental data. We focused on a sample area, the geothermal field of Larderello (Italy), where anomalous concentrations of arsenic and boron were found in the drinking water. The results obtained in this study prove that the risk to human health depends on the speciation of As, which is strictly related to the pH values reached at equilibrium with intestinal fluids. The pH values change as a function of the concentration of boric acid in drinking water. In waters characterized by high contents of B, the risk factor is amplified by the increase of the species As3+ in intestinal fluids. Specifically, this study suggests that interactions between two elements in solution, such as boric acid and arsenic, both in solution in drinking water, can have a negative impact on human health when balanced with intestinal fluids, since the effects of one may magnify the toxicity of the other

    Antiarrhythmic Drug Therapy in the Treatment of Acute and Chronic Atrial Flutter

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    : In the present article, we will focus on the pharmacologic treatment of atrial flutter aimed either at restoring/maintaining sinus rhythm or controlling the ventricular response during tachyarrhythmia. To provide a comprehensive description we will start discussing the electroanatomic substrate underlying the development of atrial flutter and the complex relationship with atrial fibrillation. We will then describe the available drugs for the treatment of atrial flutter on the bases of their electrophysiological effects and data from available clinical studies. We will conclude by discussing the general principles of rhythm and rate control treatment during atrial flutter

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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