1,721,071 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Mapping P2X and P2Y receptor proteins in striatum and substantia nigra: An immunohistological study.
No full textMembrane compartments and purinergic signalling: P2X receptors in neurodegenerative and neuroinflammatory events
No full textFunctional microglia neurotransmitters in amyotrophic lateral sclerosis
No full textToday neuroscience is dominated by the perspective that microglia are essential elements in any integrated view of the nervous system. A number of different neuroinflammatory conditions affect the CNS where microglia involvement, and particularly microgliosis, is not only a prominent feature, but also a pathogenic key mechanism of disease. On the other side, microglia can also constitute an important trigger of neuronal protection during neurodegenerative disorders. For instance in ALS and other motor neuron diseases, available evidence suggests the coexistence of quite different roles for microglia, characterized by neuroprotective functions at early stages, and neurotoxic actions during disease progression. The scope of this review is a brief discussion about microglia being activated and functioning during ALS, and particularly about neurotransmitters participating to the pathological signature of ALS microglia. We will discuss that ALS microglia can express a variety of classical neurotransmitter receptors comprising those for extracellular ATP, glutamate and histamine. We will review data indicating that the modulation of these transmitter receptors may induce beneficial effects in ALS models, so that the protective properties of microglia can be emphasized at the expenses of their toxicity
La collazione delle liberalità
No full textIl saggio esamina la disciplina della Collazione delle liberalità, offrendo innanzitutto un excursus sulle varie teorie che si sono contese il campo in relazione alla identificazione del suo fondamento giuridico. Viene quindi riservata una particolare attenzione alle questioni che risultano di maggiore complessità o che sono ancor oggi oggetto di dibattito, fornendo così anche un ampio panorama delle soluzioni proposte dalla dottrina e dalla giurisprudenza in materia.
Specifica disamina ricevono pertanto il tema delle donazioni indirette, soprattutto in riferimento all’ipotesi della cd. intestazione di beni in nome altrui, la quale, come è noto, ha dato origine ad un’accesa querelle in relazione al quantum da conferire.
Altra fattispecie a cui viene riservata un’estesa trattazione è quella della donazione di usufrutto, sempre in ragione delle problematiche che essa solleva in sede di conferimento.
This assay surveys the discipline of Collazione and first gives us an excursus on manifold theories disputed on the subject, to identify its legal basis. Thus, special attention is paid to the more complex matters or points that are still subject of debate. A broad view of solutions, suggested from doctrine and law, is here provided.
Specific examination is granted to the topic of indirect donations, mostly concerning the hypothesis of the so-called registration of assets on behalf of others. This supposition, as well-known, have given rise to an heated querelle in relation to the quantum to confer on.
Moreover a large treatment is reserved to donation of usufruct, due to the problems that it can arise when is conferred
Drug Repurposing: A Network-based Approach to Amyotrophic Lateral Sclerosis
Full text linkThe continuous adherence to the conventional “one target, one drug” paradigm has failed so far to provide effective therapeutic solutions for heterogeneous and multifactorial diseases as amyotrophic lateral sclerosis (ALS), a rare progressive and chronic, debilitating neurological disease for which no cure is available. The present study is aimed at finding innovative solutions and paradigms for therapy in ALS pathogenesis, by exploiting new insights from Network Medicine and drug repurposing strategies. To identify new drug-ALS disease associations, we exploited SAveRUNNER, a recently developed network-based algorithm for drug repurposing, which quantifies the proximity of disease-associated genes to drug targets in the human interactome. We prioritized 403 SAveRUNNER-predicted drugs according to decreasing values of network similarity with ALS. Among catecholamine, dopamine, serotonin, histamine, and GABA receptor modulators, as well as angiotensin-converting enzymes, cyclooxygenase isozymes, and serotonin transporter inhibitors, we found some interesting no customary ALS drugs, including amoxapine, clomipramine, mianserin, and modafinil. Furthermore, we strengthened the SAveRUNNER predictions by a gene set enrichment analysis that confirmed modafinil as a drug with the highest score among the 121 identified drugs with a score > 0. Our results contribute to gathering further proofs of innovative solutions for therapy in ALS pathogenesis
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