1,720,968 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Evaluation of SLC6A2 and CYP2D6 Polymorphisms’ Effects on Atomoxetine Treatment in Attention Deficit and Hyperactivity Disorder
No full textBackground There is insufficient replicated data to establish a relationship between the polymorphisms of SLC6A2 and
CYP2D6 and the treatment responses of atomoxetine (ATX) in ADHD. We focused on evaluating the effect of top-line
single nucleotide polymorphisms (SNPs) in SLC6A2 and CYP2D6 on the ATX treatment response in attention deficit and
hyperactivity disorder (ADHD).
Methods Of 160 patient records, 34 patients who met the inclusion criteria were evaluated to determine the relationship
between genotypes of ten SNPs (six of SLC6A2 and four of CYP2D6) and ATX treatment response. Additionally, the connection
between SNPs of CYP2D6 and the severity of side effects associated with ATX was analyzed in 37 patients, including
the 34 study patients, and three patients discontinued because of ATX-dependent side effects.
Results All six polymorphisms we studied in SLC6A2 were associated with the treatment response of ATX. Clinical improvement
in oppositional defiant disorder symptoms of patients with ADHD was only observed in carriers of the homozygous
“C” allele of rs3785143 (podd = 0.026). We detected an association between higher CGI-side-effect severity scores and the
“TT” genotype of rs1065852 polymorphism in CYP2D6 (p = 0.043).
Conclusions The findings of this study suggest that genotypes of polymorphisms within the SLC6A2 and CYP2D6 may play
an influential role in treatment response or the severity of side effects associated with ATX in ADHD patients
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Investigation of effects of olea europaea leaf, rubus fruticosus and nigella CV extracts on microrna expression levels on colon cancer cell lines
No full textKolorektal kanser, dünyada en yaygın görülen kanserlerden biridir. Son 30 yılda gelişen cerrahi ve görüntüleme tekniklerine rağmen kemoterapatiklerin tedavide yeterince etkin sonuçlar veremediği görülmektedir. Biyoaktif ajanlar olarak adlandırılan bitki özütleri, son yıllarda yeni tedavilerin geliştirilmesi açısından yoğun olarak araştırılmaktadır. Epigenetik mekanizmalar üzerinden etkili olduğu anlaşılan bitkisel özütlerin yeni kanser tedavi modellerinin geliştirilmesinde faydalı olacağı düşünülmektedir. Tüm bu sebepler ile mevcut tez çalışmasında kolorektal kanser hücrelerinde bitkisel özütlerin etkilerinin, önemli bir epigenetik mekanizma olan mikroRNA (miRNA) ekspresyon seviyelerindeki değişimler ile değerlendirilmesi amaçlanmıştır. Gerçekleştirilen çalışmada, Nigella sativa (çörekotu) tohum özütü (NTE), Olea europeae (zeytin) yaprağı özütü (OLE) ve Rubus fruticosus (böğürtlen) kök özütü (RKE)'nün iki kolorektal kanser hücre hattındaki (HT-29 ve LoVo) anti kanser etkisi hücre proliferasyonu ve invazyonu açısından araştırıldı ve olası anti kanser etkinin moleküler mekanizması miRNA ekspresyon seviyesinde çalışılarak epigenetik olarak değerlendirildi. WST-1 analizi sonuçlarına göre değerlendirilen bitki özütlerinin hücre proliferasyonunu anlamlı düzeyde azaltıcı etkisinin (p<0.05) olduğu belirlendi. RKE ve NTE'nin her iki hücre hattında da istatistiki olarak anlamlı seviyede (p<0.05), OLE'nin ise LoVo hücre hattında istatistiki anlamlılığa yakın seviyede (p=0.0641) hücrelerin migrasyon özelliğini inhibe ettiği görüldü. Bitki özütlerinin RT-PCR yöntemi ile miRNA ekspresyon profillerine etkisi değerlendirildiğinde RKE'nin her iki hücre hattında da miR-140 ekspresyon artışına (p<0.05), NTE ve OLE'nin ise HT-29 hücrelerinde miR-182a ekspresyonunda istatistiki olarak anlamlı seviyede (p<0.05) düşüşe neden olduğu belirlendi. Mevcut çalışmada, RKE, NTE ve OLE'nin kolorektal kanser hücrelerinde epigenetik mekanizmalar aracılığı ile hücre proliferasyonu ve migrasyonunu azaltıcı yönde etkiye sahip olduğu literatürde ilk kez ortaya koyulmuştur. İleri çalışmalar gerekmekle birlikte her üç bitki özütünün de kolorektal kanserde yeni tedavilerin araştırılmasına yönelik çalışmalar için potansiyel birer aday olabileceğini düşünmekteyizColorectal cancer one of the most common cancers in the World. Although surgical and screening techniques have been improved a lot in last 30 years, chemotherapeutics have not advanced sufficiently for a successful treatment. New treatments options for many disease by the help of plant extracts, which are called bioactive agents, have been searching intensively. Plant extracts, also effective on epigenetic mechanisms, are thought to be efficious for developing new cancer therapy approaches. Aim of this dissertation study is to evaluate changes in one of the important epigenetic mechanisms microRNA (miRNA) expression levels due to effects of plant extracts on the colorectal cell lines. In present study, Nigella sativa (black cumin) seed extract (NTE), Olea europeae (olive) leaf extract (OLE) and Rubus fruticosus (blackberry) root extract (RKE) are investigated in two colorectal cell lines (HT-29 and LoVo) for their anti-proliferative and migration properties in means of effects on microRNA expressions. Anti-proliferative effects of plant extract are evaluated by WST-1 assay and cell proliferation is reduced significantly (p<0.05). In cell migration analysis RKE and NTE reduced migration in both cell line significantly (p<0.05). Migration properties of LoVo cell line is found to be inhibited by OLE with nearly significant values (p<0.06). Real time-PCR method is used for investigation of expression differences in miRNA after extract treatment. Statistically significant increases are observed in miR-140 expressions in both cell lines after RKE treatment, and in HT-29 cell line miR-182a expression is again significantly reduced after both OLE and NTE treatments (p<0.05). Our data show that NTE, OLE, RKE have capability to inhibit colorectal cancer cell proliferation and migration by the means of epigenetic mechanisms for the first time in the literature. Although further studies should be conducted in this topic, all three plant extracts are thought to be potential candidates for future researches on new therapy options for colorectal cancer
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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