1,720,959 research outputs found
A real-world single-centre analysis of the safety and efficacy of cladribine tablets for relapsing multiple sclerosis
No full textIntroduction: Damage of frontal cortico-subcortical networks contributes to fatigue and dual-task impairment in multiple sclerosis (MS). However, the mechanisms underlying these clinical deficits in progressive (P) MS still need to be fully explored. Objectives and Aims: In this study, we investigated the associations between structural and functional MRI abnormalities of frontal cortico-subcortical circuits and fatigue and dual-task performance in PMS. Methods: Brain structural and functional MRI scans, Modified Fatigue Impact Scale (MFIS) and dual-task performances were obtained from 57 PMS patients with impaired processing speed from 4 centers and 10 healthy controls (HC). The associations of thalamic, caudate nucleus and dorsolateral prefrontal cortex (DLPFC) atrophy, microstructural abnormalities of their connecting tracts and their resting state effective connectivity (RS EC) with fatigue, single-and dual-task performances were investigated. Results: Compared to HC, PMS patients had higher fatigue (p⩽0.027) and worse dual-task performance (p<0.001). Compared to non-fatigued (MFIS<38), PMS patients with fatigue (MFIS⩾38) had lower RS EC from left-caudate nucleus to left-DLPFC (p=0.007). In PMS, higher MFIS-physical and MFIS-psychosocial scores were predicted by lower RS EC from left-caudate nucleus to left-DLPFC (R 2 =0.112, p=0.027) and higher RS EC from right-thalamus to right-DLPFC (R 2 =0.102, p=0.046), respectively. Dual-task motor performances were predicted by lower RS EC from left-DLPFC to left-thalamus (R 2 ⩾0.137, p⩽0.032). Several structural MRI measures independently predicted dual-task correct response rates (R 2 =0.307, p⩽0.010) and dual-task cognitive cost (R 2 =0.188, p=0.002). Fatigue impact was not associated with single-and dual-task performances. Conclusions: Frontal cortico-subcortical structural and functional MRI abnormalities differently contribute to fatigue impact and single-and dual-task performance in PMS
A real-world single-centre analysis of the safety and efficacy of cladribine tablets for relapsing multiple sclerosis
No full textIntroduction: Damage of frontal cortico-subcortical networks contributes to fatigue and dual-task impairment in multiple sclerosis (MS). However, the mechanisms underlying these clinical deficits in progressive (P) MS still need to be fully explored. Objectives and Aims: In this study, we investigated the associations between structural and functional MRI abnormalities of frontal cortico-subcortical circuits and fatigue and dual-task performance in PMS. Methods: Brain structural and functional MRI scans, Modified Fatigue Impact Scale (MFIS) and dual-task performances were obtained from 57 PMS patients with impaired processing speed from 4 centers and 10 healthy controls (HC). The associations of thalamic, caudate nucleus and dorsolateral prefrontal cortex (DLPFC) atrophy, microstructural abnormalities of their connecting tracts and their resting state effective connectivity (RS EC) with fatigue, single-and dual-task performances were investigated. Results: Compared to HC, PMS patients had higher fatigue (p⩽0.027) and worse dual-task performance (p<0.001). Compared to non-fatigued (MFIS<38), PMS patients with fatigue (MFIS⩾38) had lower RS EC from left-caudate nucleus to left-DLPFC (p=0.007). In PMS, higher MFIS-physical and MFIS-psychosocial scores were predicted by lower RS EC from left-caudate nucleus to left-DLPFC (R 2 =0.112, p=0.027) and higher RS EC from right-thalamus to right-DLPFC (R 2 =0.102, p=0.046), respectively. Dual-task motor performances were predicted by lower RS EC from left-DLPFC to left-thalamus (R 2 ⩾0.137, p⩽0.032). Several structural MRI measures independently predicted dual-task correct response rates (R 2 =0.307, p⩽0.010) and dual-task cognitive cost (R 2 =0.188, p=0.002). Fatigue impact was not associated with single-and dual-task performances. Conclusions: Frontal cortico-subcortical structural and functional MRI abnormalities differently contribute to fatigue impact and single-and dual-task performance in PMS
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Safety and effectiveness of cladribine tablets for multiple sclerosis: Results from a single-center real-world cohort
No full textBackground: Cladribine tablets are a highly effective immune reconstitution therapy licensed for treating re-lapsing multiple sclerosis (RMS) in Europe since 2017. Currently, there is a high demand for real-world data from different clinical settings on the effectiveness and safety profile of cladribine in MS. Methods: Within this report, we retrospectively evaluated the outcomes of RMS patients who received cladribine between August 2018 and November 2021 at our Belgian institute. Patients with data for three effectiveness endpoints, more specifically, relapses, MRI observations, and confirmed disability worsening were incorporated into the analysis of 'no evidence of disease activity' (NEDA-3) re-baselined at 3 months. Safety endpoints included lymphopenia, liver transaminases, and adverse events (AEs) during follow-up. Descriptive statistics and time-to-event analysis were performed, including subgroup analysis by pre-treatment. Results: Of the 84 RMS patients included in this study (age 42 [33-50], 64.3% female, diagnosis duration 6 [2-11] years, baseline EDSS 2.5 [1.5-3.6]), 14 (16.7%) patients experienced relapses, while disability pro-gression and brain MRI activity occurred in 8.5% (6/71) and 6.3% (5/79). This resulted in 72.6% (n = 69, standard error 6%) retaining NEDA-3 status at the mean follow-up time of 22.6 +/- 11.5 months. During the first year after cladribine initiation, disease activity prevailed more in patients with >= 2 prior DMTs and those switching from fingolimod, although both trends were not statistically significant. In terms of safety, 67.9% reported at least one AE during follow-up, the most frequent being fatigue (64.9%) and skin-related problems (38.6%). Conclusion: Overall, our research results confirm cladribine's safety and effectiveness among RMS patients in real-world conditions. After the re-baseline, we observed high rates of NEDA-3-retention, and no new safety signals were noted
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