1,721,296 research outputs found
Progetto dal titolo “A double-blind randomized study on alcohol intake and craving reduction in alcohol-dependent patients comparing bacoflen 10mg, bacoflen 20 mg and placebo
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Treating Alcohol Use Disorder in Patients with Alcohol Associated Liver Disease
No full textAlcohol use disorder (AUD) is one of the main causes of global death and disability. The liver represents the main target of alcohol damage and alcohol associated liver disease (ALD) represents the first cause of liver cirrhosis in Western Countries. Alcohol abstinence is the main goal of treatment in AUD patients with ALD, because treatments for ALD are less effective when drinking continues. Moreover, the persistence of alcohol consumption is associated with higher mortality, increased need for liver transplantation and graft loss. The most effective treatment for AUD is the combination of psychosocial interventions, pharmacological therapy and medical management. However, the effectiveness of these treatments in patients with ALD are doubtful even because AUD patients with ALD are usually excluded from pharmacological trials due to concerns on liver safety. This narrative review will discuss the treatment options for AUD-ALD patients focusing on controversies in pharmacological therapy
Gamma-hydroxybutirric acid: efficacy, potential abuse and dependence in the treatment of alcohol addiction
No full textThe main objective in alcoholism therapy is to achieve and maintain abstinence and to prevent relapse. Pharmacotherapy may be necessary in treating persons who are not helped by group or psychosocial support alone. Among the substances experimented with in the past few years, gamma-hydroxybutyric acid has been effective in preventing alcohol withdrawal syndrome and in inducing a reduction in craving and an increase in the abstinence rate in treated alcoholics, in view of the alcohol-mimicking effects of the drug on the central nervous system. However, a possible development of craving for the drug and the risk of abuse and physical dependence have been reported in subjects who used gamma-hydroxybutyric acid for different reasons, including alcoholism therapy. The present review updates the existing differences in drug abuse behavior, side effects, and poisoning in the use of gamma-hydroxybutyric acid in a treatment alcoholism program and in self nonclinical illicit use
Treatment of alcoholic fatty liver: is the metabolic effect of metadoxine the only reason for improved liver function?
No full textL’acido gamma-idrossibutirrico nel trattamento dei pazienti alcol-dipendenti
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Gamma hydroxybutyric-acid in the treatment of alcohol dependence: possible craving development for the drug
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