177,439 research outputs found
The oral tyrosine kinase inhibitors lapatinib and sunitinib: new opportunities for the treatment of brain metastases from breast cancer?
No full textCombining temozolomide with other antitumor drugs and target-based agents in the treatment of brain metastases: an unending quest or chasing a chimera?
No full textINTRODUCTION: Medical treatment of brain metastases (BM) is still a controversial issue in cancer therapy being mainly limited by the existence of the BBB. Temozolomide (TMZ) can cross BBB and several clinical trials have been performed attempting to demonstrate the activity of TMZ in combination with whole brain radiotherapy (WBRT) in the treatment of BM. AREAS COVERED: This review summarizes TMZ-WBRT combination trials highlighting the confounding factors that limit the interpretation of the achieved results and describes the main clinical trials using TMZ in combination with other cytotoxic or biological agents. The main limitations of these trials are: i) patient selection for heterogenous primitive neoplasms and for heterogeneous neuro-functional score; ii) poor penetration across BBB of the other drugs; iii) cumulative toxicity and iv) poor control of extracranial tumor sites. EXPERT OPINION: Biotechnological, biological and biochemical advances in the management of BM could allow in short time the definition of new schedules based on the rational use of new anticancer weapons. The latter could be cytotoxic agents encapsulated in nanotechnological tools able to cross BBB, lipophilic small kinase inhibitors (lapatinib, sunitinib), mTOR inhibitors and PARP inhibitors combined with old drugs such as TMZ
Detection of pH 4.6 insoluble beta-lactoglobulin in heat-treated milk and Mozzarella cheese
No full textDifferent protein aggregates including beta-lactoglobulin (beta-lg) were detected in the pH 4.6 insoluble fraction recovered from actual heat-treated milk samples by gel electrophoresis and immunoblotting. A competitive enzyme-linked immunosorbent assay (ELISA) using anti-beta-lg polyclonal antibodies was developed to analyze the beta-lg partition in the protein fractions obtained upon acidification of both milk and Mozzarella cheese at pH 4.6. According to ELISA determinations, nearly 90% of the pH 4.6 soluble beta-lg included in raw milk was found in the pH 4.6 insoluble fraction of ultrahigh temperature (UHT)-treated milk. As concerns Mozzarella cheese analysis, ELISA results indicated that about 36% of the total beta-lg milk content was transferred from pasteurized milk to Mozzarella cheese, whereas less than 0.5% was transferred from raw milk. The pH 4.6 insoluble beta-lg proved to be a suitable indicator of the intensity of the heat treatment applied to milk. The ELISA-based detection of this parameter was suggested for quality control of both drinking milk and raw milk cheese
Antigenicity of the 139-149 alphas1-casein region in different species revealed by ELISA and immunoblotting using antipeptide antibodies
No full textLocal products as a key for economic development drive by tourism: a case study research in Irpinia
No full textPurpose - Literature on country of origin effect has mostly focused on the effect a country has on the consumers’ perceived quality of local products. However, there are many cases in which product image might be considered much stronger than Country image, that being a potential resource that could be exploited for economic growth. Thus our research tries to shed light on the potential influence of local products on the economic development of a territorial area. Finally our study shows that local products perceived as being of high quality, have a great impact on country image for tourism or business opportunities, above all when scarce information on the product area is available to consumers.
Design/methodology/approach - The conceptual framework above presented was tested in Irpinia, a little area in Southern Italy, well known for its local production of typical food and wines. Our research goals were to discover and analyze those factors that may influence country perception related to the consumption of local products. On this basis, our unit of analysis was composed by people hosted by tourist facilities (hotel, restaurants, etc,) located in Irpinia. Research method is mainly quantitative: data collection was performed by mean of a semi-structured questionnaire; interviewees were selected through not probability sampling procedure, whereas data analysis, performed through SPSS software, involved multivariate techniques.
Findings - By giving reasons why tourists chose Irpinia (area or products), the research shows that there could be a dyadic association between country of origin and product image.
Practical implications - The paper provides, through a literature review and an empirical study, an innovative marketing and communication tool regarding both product/brand tactics and the improvement of tourism and territorial business opportunities.
Originality/value - While most literature focuses on the effects of country of origin effect over perceived product quality, the study proposes to use local products as marketing and communication tools to promote the area. The paper also highlights the dyadic relationship between product/brand and country of origin. These considerations allow the paper, with an adaptation of the initial framework, to provide academic and practical suggestions in operative marketing and communication regarding product/brand and territorial touristic developmen
The aptitude of caprine milk to cheesemaking. Interrelationships between milk composition and rheological properties of curd and derived cheeses
No full textAntipeptide antibodies as analytical tools to discriminate among bovine alphas1-casein components
No full text
- …
