1,721,399 research outputs found
Blood pressure and metabolic phenotypes in relation to SAH gene variants and ADRB1 Arg389Gly and ADRAB2 I/D polymorphisms in white family-based population samples
Full text linkObjectives: Aim of the present doctoral dissertation is independent confirmation in family-based population samples, using strict appropriate statistical approach, of the associations, if any, between blood pressure (BP) and related metabolic phenotypes, analysed as continuous traits, and variations in candidate genes arising from experimental animal models [Spontaneously hypertensive rat-clone A-Hypertension-associated (SAH) gene], and from physiological cascades of the adrenergic system [alfa2B- (ADRAB2) and beta1- (ADRB1) adrenergic receptors].
Methods and Results: The SAH gene variants were evaluated in the frame of the European Project On Genes in Hypertension. In details, 2603 relatives from 560 families and 31 unrelated subjects (mean age 38.8?15.7 years; 52.1% women) were randomly recruited from six European populations. Systolic/diastolic BP, body mass index, triceps skinfold, waist-to-hip ratio, serum total and HDL cholesterol, serum triglycerides and blood glucose were measured. All subjects were genotyped for the G-1606A and -962 del/ins polymorphisms and the allele frequencies were 11.8% and 29.5% for -1606A and -962del, respectively. Lewontin’s D’ was 0.97 (p<0.0001). Haplotype frequencies were 58.8% for -1606G plus -962ins, 29.5% for -1606G plus -962del, and 11.7% for -1606A plus -962ins. Both before and after adjustment for covariates, none of the phenotype-genotype associations approached statistical significance. Family-based analyses did not reveal any population stratification (P?0.67) as a possible explanation of those negative results.
The association studies between ADRB1 Arg389Gly and ADRA2B I/D polymorphisms of the beta1- and alfa2B-adrenergic receptors with BP and metabolic phenotypes, were conducted in a subsample of the EPOGH cohort. 1802 relatives from 175 families and 79 unrelated subjects (mean age 45.5?15.7 years; 51.1% women) were randomly recruited from a Caucasian population living in Northern Belgium. Systolic/diastolic BP, body mass index, waist-to-hip ratio, serum total and HDL cholesterol were measured. All subjects were genotyped for the ADRA2B I/D and ADRB1 Arg389Gly polymorphisms. The ADRA2B genotypes (II 45.7%, ID 41.7%, and DD 12.5%; P=0.05) and the ADRB1 genotypes (ArgArg 56.2%, ArgGly 36.9%, and GlyGly 6.9%; P=0.66) did not deviate from Hardy–Weinberg proportions. ADRB1 ArgArg homozygotes, compared with Gly allele carriers, had higher diastolic BP (79.4 vs 78.4 mmHg; P=0.012), and higher serum HDL cholesterol (1.33 vs 1.29 mmol/l; P=0.020). None of the other cardiovascular or metabolic phenotypes in relation to the two polymorphisms reached significance. The family-based analyses did not reveal population stratification (P?0.23).
Conclusions: The present study gives evidence in favour of association of diastolic BP and HDL cholesterol with the ADRB1 Arg389Gly polymorphism in the absence of population stratification. However, the evidences supporting association of hypertension or hypertension-related phenotypes with the SAH gene remain equivocal in human studies
Zella Patterson Collection
No full textPhotograph of a Hawaiian Party in the William H. Hale Student Center, Langston University, Langston, OK, June 4, 1966. Photo by Achille C. Hebert, Langston, OK
Zella Patterson Collection
No full textPhotograph of Governor Henry Bellmon speaking at Langston University, Langston, OK. President William H. Hale, seated to Bellmon's right. Photo by Achille C. Hebert, Langston, OK
Achille C. Varzi, Claudio Calosi, Le tribolazioni del filosofare
Full text linkRecensione del volume "Le tribolazioni del Filosofare. Comedia Metaphysica ne la quale si tratta de li errori e de le pene de l’Infero" di Achille C. Varzi e Claudio Calos
Zella Patterson Collection
No full textPhotograph of Dr. M. B. Tolson presenting a copy of one of his books to a campus visitor during an assembly, Langston University, Langston, OK, c.1955-1959. Photo by Achille C. Hebert, Langston, OK
1948 Letter from Association des Ex-Presidents des Unions Canadienne et Americaine de Raquetteurs
Full text linkLetter from Achille C. Poulin, Secretary Treasurer of the Association des Ex-Presidents des Unions Canadienne et Americaine de Raquetteurs, to Louis-Philippe Gagné.https://digitalcommons.usm.maine.edu/fac-lpg-letters-1948-01-06/1063/thumbnail.jp
Achille C. Varzi, Il mondo messo a fuoco. Storie di allucinazioni e miopie filosofiche
No full textRecensione di "Achille C. Varzi, Il mondo messo a fuoco. Storie di allucinazioni e miopie filosofiche
Hylas e Philonous dieci anni dopo:
No full textTen years after the first, this is the second chapter of the dialogue between Hylas (aka Maurizio Ferraris) and Philonous (aka Achille C. Varzi), one of the decisive texts in the debate of new realism. There is, however, a small yet decisive shift in focus—from what is there to what could be there
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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