1,721,012 research outputs found
La leptina riduce l'effetto inibitorio di IL-beta sull'espressione genica di beta-caseina in cellule mammarie differenziate
No full textCharacterization of ipscs derived from bovine mammary epithelial cells and bovine skin fibroblasts
No full textSTAT-3 interfered mammary cells are irresponsive to beta-casein mRNA expression induced by leptin
No full textReprogramming of Bovine Mammary Epithelial Cells And Bovine Skin Fibroblasts With Pluripotency Factors, a New Perspective in Veterinary Science and Milk Production
No full textApplication studies of in-vitro bioactivity tests for the development of cell-based biosensors
No full textPreparazione di differenti resine di affinità per la purificazione del recettore del complemento di tipo 1 (CR1) da piastrine di coniglio e neutrofili polimorfonucleati.
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Hepatocyte growth factor exerts multiple biological functions on bovine mammary epithelial cells
No full textThe met proto-oncogene product Met is a member of the family of tyrosine kinase growth factor receptors, and hepatocyte growth factor/scatter factor (HGF/SF) has been identified as its only ligand. Bovine Met and HGF/SF have been recently cloned and their expression has been characterized in the mammary gland, but no data regarding the biological effects of this ligand/receptor
couple in bovine mammary cells are yet available. We examined the role of HGF/SF and its receptor in a bovine mammary epithelial cell line (BME-UV). Expression of Met at the mRNA level in BME-UV mammary epithelial cells evaluated by real-time PCR was similar to the expression in MDCK cells, a widely used
model for Met biology. Met expression in BME-UV at the protein level was confirmed by western blot. The analysis of some signal transductional pathways downstream from the Met receptor revealed that HGF/SF addition to BME-UV cells induced activation of the extracellular signal-regulated kinase 1⁄2 proliferative
pathway and the Akt antiapoptotic pathway. The BME-UV cells treated with HGF responded with increased proliferation, cell scatter, and motility. Met activation by HGFinduced degradation of the extracellular matrix and migration through matrigel coated transwells. Moreover, BME-UV cells included in a 3-dimensional
matrix of collagen and treated with HGF developed tubular structures, reminiscent of the mammary gland ducts. These data indicate that HGF and Met might be important regulators of mammary gland growth, morphogenesis, and development in the bovine
IL-12 induced IFN-g does not directly act on TSA and C26 tumor cells for its antitumoral activity
No full textIL-12 induced IFN-gamma does not directly act on TSA and C26 tumor cells for its antitumoral activity
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