1,721,199 research outputs found
Letter by Dixon et al regarding article, "Watching television and risk of mortality from pulmonary embolism among japanese men and women: the JACC study (Japan Collaborative Cohort)"
Full text linkInflammatory markers in STelevation acute myocardial infarction
No full textAfter acute myocardial infarction, ventricular remodeling is characterized by changes at the molecular, structural, geometrical and functional level that determine progression to heart failure. Inflammation plays a key role in wound healing and scar formation, affecting ventricular remodeling. Several, rather different, components of the inflammatory response were studied as biomarkers in ST-elevation acute myocardial infarction. Widely available and inexpensive tests, such as leukocyte count at admission, as well as more sophisticated immunoassays provide powerful predictors of adverse outcome in patients with ST-elevation acute myocardial infarction. We review the value of inflammatory markers in ST-elevation acute myocardial infarction and their association with ventricular remodeling, heart failure and sudden death. In conclusion, the use of these biomarkers may identify subjects at greater risk of adverse events and perhaps provide an insight into the mechanisms of disease progression
Comment on Hypoglycemia and hyperglycemia are risk factors for falls in the hospital population by Berra et al
No full textDual antiplatelet therapy after drug-eluting stent implantation: When is "enough" enough?
No full textWhat meta-analyses teach us: pros and cons
No full textThe exponential increase in publications focusing on important clinical issues represents a major challenge for patients, physicians, and decision-makers, despite the braggadocio of many experts. Meta-analysis, when conducted within the context of a systematic review, offers an efficient and potent tool to summarize the clinical evidence accrued on a specific clinical question. Despite their many strengths, which include statistical precision, external validity, and the opportunity to analyze subgroups and moderators, meta-analyses also have many limitations. In addition, they are criticized because potentially an exercise in "mega-silliness", mixing "apples and oranges", unable to improve the quality of primary studies (in keeping with the say "garbage in-garbage out"), and focusing on an "average patient" who is only hypothetical. Yet, it is evident that meta-analyses will continue to play a key role in informing decision making whenever the best approach is not self-evident. Thus, it is mandatory to know their main features in order to use them critically and constructively, without being dominated nor scared
Spontaneous rupture of coronary artery in human immunodeficiency virus-positive patient treated with highly active anti-retroviral therapy (HAART)
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Editorial: New Insights Into Oxidative Stress and Inflammation in the Pathophysiology and Treatment of Cardiovascular Diseases
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