14 research outputs found
Cadmium accumulation and physiological response of sunflower plants to Cd during the vegetative growing cycle
No full textThe effects of soil Cd contamination on Cd accumulation and distribution, growth and physiological responses of sunflower plants were investigated. Plants were subject to six levels of soil contamination (from 2.5 to 15 mg Cd kg/soil) with an untreated control, from the emergence of the cotyledon leaves until the harvest, when plants were at the flower bud stage. An overall increase of Cd concentration was found in all tissues of the plants (roots, stem, young, mature and old leaves) by increasing the Cd contamination in the soil. Regardless of treatments, Cd concentration in roots always exceeded those in the aboveground dry matter with a low translocation from roots to shoots. At early stage of growth, Cd concentration in plants was higher than at the flower bud stage. Soil Cd contamination did not affect plant growth, relative water content and gas exchange parameters. Negative and significant correlation was only found between Cd concentration in the young leaves and chlorophyll concentration at the end of vegetative growing stage. Roots and old leaves are the main metal sinks suggesting a defense or tolerance mechanism of the plants to avoid toxic levels in physiologically most active apical tissues.
These results should be tested in open field to verify the suitability of sunflower in the area of phytotechnologies
Variation of glucosinolates concentration and root growth of horseradish as affected by nitrogen and sulphur supply
No full textThe aim of the study was to evaluate total and individual glucosinolates concentration, root weight and diameters of horseradish accessions (Cor and Mon) grown by adding nitrogen (N) and sulphur (S) and harvested at the beginning (late autumn) and towards the end (early spring) of the harvest period. The concentration of the 9 glucosinolates (GLS) quantified in roots varied greatly between accessions (6-fold higher in Cor) and with fertilization
(N alone led to an increase of 64% of GLS with an additional enhancement of 65% when S was added to N). Root GLS concentration was significantly higher in early spring compared to the previous harvest in late autumn (12.5 vs 8.9 μmol/g DW (dry weight)); a drastic decline of GLS (2.7 μmol/g DW) occurred in root harvested in the following autumn from plants left ad hoc in the field. The aliphatic sinigrin was the most abundant (80% of total GLS), followed by the aromatic gluconasturtiin and the indolic glucobrassicin (5.8% and 4.7%, respectively). Root diameter and weight increased in plants treated with fertilizers (19% and 61%, respectively) and throughout the harvests with Cor showing values double with respect to Mon (925 vs 476 g/plant). Relationships between GLS concentration and root weight (R2 = 0.61) and diameter (R2 = 0.69) were improved by excluding the roots harvested from plants left ad hoc in the field that showed the worst performances
Lysimetric determination of muskmelon crop coefficients cultiveted under plastic mulches
No full textA trial was carried out at the lysimeter station in southern Italy on muskmelon crop cultivated with and without plastic mulch during spring–summer in 2001 and 2003. The objective of the experiment was to verify the reliability of the crop evapotranspiration (ETc) estimate by means of the most recent update of the FAO Irrigation and Drainage Paper 56, in comparison with ETc directly measured by two mechanical weighing lysimeters.
Crop coefficients (Kc) were determined during different development stages based on lysimetric measures of ETc and of the reference evapotranspiration (ET0) estimated through the Penman Monteith and the Hargreaves methods. On melon crop cultivated without plastic mulch, corrected crop coefficients (Kc) following the last FAO Irrigation and Drainage Paper 56 procedures were well correlated with those measured from lysimeter and were as reliable as the ETc estimate. In contrast, values of Kc proposed by FAO Irrigation and Drainage Paper 56 for crops grown with plastic mulch were meaningfully lowers than those measured from lysimeter, loading to an underestimation of water consumption. On muskmelon, cultivated with and without plastic mulch, it is necessary to adapt development phase duration, suggested by the FAO Irrigation and Drainage Paper 56, to the real phenology of the employed cultivar. An adaptation of the phenology to the real duration of the single phases is essential to avoid error in the estimate of ETc
Culturable bacteria from Zn- and Cd-accumulating Salix caprea with differential effects on plant growth and heavy metal availability.
No full textAims: To characterize bacteria associated with Zn ⁄ Cd-accumulating Salix
caprea regarding their potential to support heavy metal phytoextraction.
Methods and Results: Three different media allowed the isolation of 44 rhizosphere
strains and 44 endophytes, resistant to Zn ⁄Cd and mostly affiliated with
Proteobacteria, Actinobacteria and Bacteroidetes ⁄ Chlorobi. 1-Aminocyclopropane-
1-carboxylic acid deaminase (ACCD), indole acetic acid and siderophore
production were detected in 41, 23 and 50% of the rhizosphere isolates and in
9, 55 and 2% of the endophytes, respectively. Fifteen rhizosphere bacteria and
five endophytes were further tested for the production of metal-mobilizing
metabolites by extracting contaminated soil with filtrates from liquid cultures.
Four Actinobacteria mobilized Zn and ⁄ or Cd. The other strains immobilized
Cd or both metals. An ACCD- and siderophore-producing, Zn ⁄ Cd-immobilizing
rhizosphere isolate (Burkholderia sp.) and a Zn ⁄ Cd-mobilizing Actinobacterium
endophyte were inoculated onto S. caprea. The rhizosphere isolate
reduced metal uptake in roots, whereas the endophyte enhanced metal accumulation
in leaves. Plant growth was not promoted.
Conclusions: Metal mobilization experiments predicted bacterial effects on
S. caprea more reliably than standard tests for plant growth-promoting activities.
Significance and Impact of the Study: Bacteria, particularly Actinobacteria,
associated with heavy metal-accumulating Salix have the potential to increase
metal uptake, which can be predicted by mobilization experiments and may be
applicable in phytoremediation
Assessment of cadmium uptake and nutrient content in sunflower plants grown under Cd stress
No full textIt's a long way to the top: Plant species diversity in the transition from managed to old-growth forests
No full textQuestions: Do vascular plant species richness and beta-diversity differ between managed and structurally complex unmanaged stands? To what extent do species richness and beta-diversity relate to forest structural attributes and heterogeneity?. Location: Five national parks in central and southern Italy. Methods: We sampled vascular plant species composition and forest structural attributes in eight unmanaged temperate mesic forest stands dominated or co-dominated by beech, and in eight comparison stands managed as high forests with similar environmental features. We compared plant species richness, composition and beta-diversity across pairs of stands (unmanaged vs managed) using GLMMs. Beta-diversity was quantified both at the scale of each pair of stands using plot-to-plot dissimilarity matrices (species turnover), and across the whole data set, considering the distance in the multivariate species space of individual plots from their centroid within the same stand (compositional heterogeneity). We modelled the relationship between species diversity (richness and beta-diversity) and forest structural heterogeneity and individual structural variables using GLMMs and multiple regression on distance matrices. Results: Species composition differed significantly between managed and unmanaged stands, but not richness and beta-diversity. We found weak evidence that plant species richness increased with increasing levels of structural heterogeneity and canopy diversification. At the scale of individual stands, species turnover was explained by different variables in distinct stands, with variables related to deadwood quantity and quality being selected most often. We did not find support for the hypothesis that compositional heterogeneity varies as a function of forest structural characteristics at the scale of the whole data set. Conclusions: Structurally complex unmanaged stands have a distinct herb layer species composition from that of mature stands in similar environmental conditions. Nevertheless, we did not find significantly higher levels of vascular plant species richness and beta-diversity in unmanaged stands. Beta-diversity was related to patterns of deadwood accumulation, while for species richness the evidence that it increases with increasing levels of canopy diversification was weak. These results suggest that emulating natural disturbance, and favouring deadwood accumulation and canopy diversification may benefit some, but not all, facets of plant species diversity in Apennine beech forests
Water use assessment in muskmelon by the Penman-Monteith "one-step" approach
No full textThe use of the "one-step" approach of Penman-Monteith (P-M) to assess crop water use has its limit in the lack of user friendly methodologies for a daily assessment of crop canopy resistance, rc. The model proposed by Monteith [Monteith, J.L., 1965. Evaporation and environment. In: Fogg, G.E. (Ed.), The State and Movement of Water in Living Organism. Soc. Exp. Biol. Symp. 19, 205-234] to estimate rc (rc = 100/LAI), although it is simple, requires the knowledge of LAI value during growing cycle. This work aims to propose an easy-to-use methodology for irrigation scheduling, to assess the values LAI gets during the growing cycle and thus for canopy resistance assessment. In muskmelon crop, grown with and without plastic film mulching, canopy resistance was measured by P-M formula inversion, clarifying the unknown resistivity term, being crop evapotranspiration known by lysimeter-based measurements. Measured canopy resistance was compared with the one estimated by Monteith model (1965), both in its original version and in the form we simplified in terms of LAI value during crop cycle. Thus, we compared the evapotranspiration assessed by the "one-step" use of P-M equation, with those estimated by the classical "two-step" approach, using crop coefficients, and with that directly measured by lysimeters. In particular in the mulched crop the "one-step" approach of P-M overestimates water use only by 4%, while the "two steps" approach underestimates water use by 17%. Despite both the methodologies proposed for LAI calculation and the Monteith model to assess canopy resistance extremely simplify more complex processes, they were able to give a good accuracy to assess muskmelon water use by the P-M "one-step" equation. Comparing the "one-step" and the more used "two-step" approaches it came out that, despite the latter is better correlated to the data measured by a lysimeter, it does not achieve a more accurate assessment compared to the "one-step" approach; in particular, in the mulched crop, the "two-step" approach significantly underestimates water use, while its estimation is reliable with the "one-step" approach.Evapotranspiration Canopy resistance Aerodynamic resistance Crop coefficient
Development of Loop-Mediated Isothermal Amplification for the Detection of Prototheca bovis Directly from Milk Samples of Dairy Cattle
No full textapplication/pdfPrototheca bovis is an algal emerging pathogen in dairy farms causing refractory protothecal mastitis with increasing incidence worldwide and significant economic impact. P. bovis infects cows throughout the lactation cycle, including dry periods, and can persist in the udder and the environment for a long time. Since P. bovis does not respond to treatments with antibiotics, the suggested sanitary measure to restrict the spread is culling infected animals. A point-of-care test for early detection of the causative agent is critically needed to guide farm management and the appropriate treatment of mastitis. Loop-mediated isothermal amplification (LAMP) is a highly specific molecular method, time-saving, cost-effective and easy to perform in limited settings. This study aimed to develop a LAMP assay for P. bovis detection directly from milk samples; it was employed in conjunction with a commercial DNA extraction kit which was previously used to extract DNA from milk specimens containing microbes. The LAMP assay detected P. bovis DNA within 1 h in milk samples spiked with P. bovis at a concentration of 50 cells/μL, enabling on-farm disease monitoring and decision-making based on a reliable diagnosis. The LAMP method will contribute to the accurate and rapid identification of P. bovis in asymptomatic or recurrent mastitis cases and consequently aid the implementation of targeted control measures and the reduction of losses in milk production. © 2024, The Author(s), under exclusive licence to Springer Nature B.V.journal articl
Development of Loop-Mediated Isothermal Amplification for the Detection of Prototheca bovis Directly from Milk Samples of Dairy Cattle
No full textapplication/pdfPrototheca bovis is an algal emerging pathogen in dairy farms causing refractory protothecal mastitis with increasing incidence worldwide and significant economic impact. P. bovis infects cows throughout the lactation cycle, including dry periods, and can persist in the udder and the environment for a long time. Since P. bovis does not respond to treatments with antibiotics, the suggested sanitary measure to restrict the spread is culling infected animals. A point-of-care test for early detection of the causative agent is critically needed to guide farm management and the appropriate treatment of mastitis. Loop-mediated isothermal amplification (LAMP) is a highly specific molecular method, time-saving, cost-effective and easy to perform in limited settings. This study aimed to develop a LAMP assay for P. bovis detection directly from milk samples; it was employed in conjunction with a commercial DNA extraction kit which was previously used to extract DNA from milk specimens containing microbes. The LAMP assay detected P. bovis DNA within 1h in milk samples spiked with P. bovis at a concentration of 50 cells/μL, enabling on-farm disease monitoring and decision-making based on a reliable diagnosis. The LAMP method will contribute to the accurate and rapid identification of P. bovis in asymptomatic or recurrent mastitis cases and consequently aid the implementation of targeted control measures and the reduction of losses in milk production. © 2024, The Author(s), under exclusive licence to Springer Nature B.V
Genetics of schizophrenia and affective psychoses
No full textPART 1 - THE GENETICS OF SCHIZOPHRENIA AND AFFECTIVE PSYCHOSES (pages 4-
69)This comprises an overview and critique of the work that led to the publications
that form the thesis.PART 2 - THE REFERENCE LISTS OF THE PUBLICATIONS DISCUSSED, (pages 70-124)1987Kutcher, S.P., Blackwood, D.H.R., St. Clair, D.M., Gaskell, D.F., and Muir, W.J.
(1987) Major author
"Auditory P300 in borderline personality disorder and schizophrenia"
Archives of General Psychiatry, 44: 645-6501988Blackwood, D.H.R., St. Clair, D.M., Muir, W.J., Oliver, C.J., and Dickens, P.
(1988) Minor author
"The development of Alzheimer's diseases in Down's syndrome assessed by
auditory event-related potentials"
Journal of Mental Deficiency Research, 32: 439-453
Muir, W.J., Squire, I., Blackwood, D.H.R., Speight, M.D., St. Clair, D.M., Oliver,
C., and Dickens, P. (1988)
"Auditory P300 response in the assessment of Alzheimer's disease in Down's
syndrome: a two year follow-up study" Major author
Journal of Mental Deficiency Research, 32: 455-4631989Blackwood, D.H.R., Muir, W.J., St. Clair, D.M., and Evans, H.J. (1989) Major
author
"Schizophrenia and chromosomes" (Letter)
Lancet, ii: 1459
Kutcher, S.P., Blackwood, D.H.R., Gaskell, D.F., Muir, W.J., and St. Clair, D.M.
(1989) Major author
"Auditory P300 does not differentiate borderline personality disorder from
schizotypal personality disorder"
Biological Psychiatry, 26: 766-774
St. Clair, D.M., Blackwood, D.H.R., and Muir, W.J. (1989a) Major author
"P300 abnormality in schizophrenic subtypes"
Journal of Psychiatric Research, 23: 49-551990Blackburn, I.M., Roxborough, H.M., Muir, W.J., Glabus, M., and Blackwood,
D.H.R. (1990) Minor author
"Perceptual and physiological dysfunction in depression"
Psychological. Medicine, 20: 95-103
St. Clair, D., Blackwood, D., Muir, W., Carothers, A., Walker, M., Spowart, G.,
Gosden, C., and Evans, H.J. (1990) Major author
"Association within a family of a balanced autosomal translocation with major
mental illness"
Lancet, 336: 13-161991Blackwood, D., St. Clair, D., and Muir, W. (1991a) Major author
"DNA markers and biological vulnerability markers in families multiply affected
with schizophrenia"
European Archives of Psychiatry and Clinical Neuroscience, 240: 191-196
Blackwood, D.H.R., St. Clair, D.M., Muir, W.J., and Duffy, J. (1991b) Major
author
"Auditory P300 and eye tracking dysfunction in schizophrenic pedigrees"
Archives of General Psychiatry, 48: 899-909
Blackwood, D.H.R., Young, A.H., McQueen, J.K., Martin, M.J., Roxborough,
H.M., Muir, W.J., St Clair, D.M., and Kean, D.M. (1991) Major author
"Magnetic resonance imaging in schizophrenia: altered brain morphology
associated with P300 abnormalities and eye tracking dysfunction"
Biological Psychiatry, 30: 753-769
Morris, S.W., Muir, W., and St. Clair, D. (1991) Major author
"Dinucleotide repeat polymorphism at the human tyrosinase gene"
Nucleic Acids Research, 19: 69681993Evans, K.L., Fantes, J., Simpson, C., Arvelier, B., Muir, W., Fletcher, J., Van
Heyningen, V., Steel, K.P., Brown, K.A., Brown, S.D.M., St. Clair, D., and
Porteous, D. (1993) Minor author
"Fluman olfactory marker protein maps close to tyrosinase and is a candidate
gene for Usher syndrome type I"
Human Molecular Genetics, 2: 115-118
Fletcher, J.M., Evans, K., Baillie, D., Byrd, P., Hanratty, D., Leach, S., Julier, C.,
Gosden, J.R., Muir, W., Porteous, D.J., St. Clair, D., and Van Heyningen, V.
(1993) Minor author
"Schizophrenia-associated chromosome 11 q21 translocation: identification of
flanking markers and development of chromosome 11 q fragment hybrids as
cloning and mapping resources"
American Journal of Human Genetics, 52: 478-490
Roxborough, H.M., Muir, W.J., Blackwood, D.H.R., Walker, M.T. and Blackburn,
I.M. (1993) Major author
"Neuropsychological and P300 abnormalities in schizophrenics and their
relatives"
Psychological Medicine, 23: 305-3141994Blackwood, D.H.R., Ebmeier, K.P., Muir, W.J., Sharp, C.W., Glabus, M., Walker,
M., Souza, V., Dunan, J.R., Murray, C., Dougall, N., and Goodwin, G.M. (1994)
Major author
"Correlation of regional cerebral blood flow measured by single photon emission
tomography with P300 latency and eye movement abnormalities in
schizophrenia"
Acta Psychiatrica Scandinavica, 90: 157-166
Blackwood D.H.R., Muir, W.J., Roxborough, H.M., Walker, M.T., Townshend, R.,
Glabus, M., and Wolff, S. (1994) Major author
"Schizoid personality in childhood: auditory P300 and eye tracking responses at
follow up in adult life"
Journal of Autism and Developmental Disorders, 24: 487-500
Dr Walter J Muir, Doctor of Science Thesis, the University of Edinburgh 75
Glabus, M.F., Blackwood, D.H.R., Ebmeier, K.P., Walker, M.T., Souza, V.,
Dunan, J.R., Sharp, C.W. and Muir, W.J. (1994) Major author
"Methodological considerations in measurement of the P300 component of the
auditory ERP in schizophrenia"
Electroencephalography Clinical Neurophysiology, 90: 123-134
Morris, S., Leung, J., Sharp, C., Blackwood, D., Muir, W., and St. Clair, D. (1994)
Major author
"Screening schizophrenic patients for mutations in the amyloid precursor protein
gene"
Psychiatric Genetics, 4: 23-27
Sham, P.C., Morton, N.E., Muir, W.J., Walker, M., Collins, A., Shields, D.C., St.
Clair, D.M., and Blackwood, D.H.R. (1994) Major author
"Segregation analysis of complex phenotypes: an application to schizophrenia
and auditory P300 latency"
Psychiatric Genetics, 4: 29-38
Sharp, C.W., Muir, W.J., Blackwood, D.H.R., Walker, M., Gosden, C., St. Clair,
D.M. (1994) Major author
"Schizophrenia and mental retardation associated in a pedigree with retinitis
pigmentosa and sensorineural deafness"
American Journal of Medical Genetics, (Neuropsychiatric Genetics), 54: 354-3601995Brookes, A.J., Slorach, E.M., Evans, K.L., Thomson, M.L., Gosden, C.M., Muir,
W.J., and Porteous DJ. (1995) Major author
"Identifying genes within microdissected genomic DNA: Isolation of brain
expressed genes from a translocation region associated with inherited mental
illness"
Mammalian Genome, 6: 257-262
de Souza, V.B.N., Muir, W.J., Walker, M.T., Glabus, M., Roxborough, H.M.,
Sharp, C.W., Dunan, J.R., and Blackwood, D.H.R. (1995) Major author
"Auditory P300 event-related potentials and neuropsychological performance in
schizophrenia and bipolar affective disorder"
Biological Psychiatry, 37: 300-310
Evans, K.L., Brown, J., Shibasaki, Y., Devon, R.S., Arvelier, B., Christie, S.,
Maule, J.C., Baillie, D., Slorach, E.M., Anderson, S.M., Gosden, J.R., He, L.,
Petit, J., Weith, A., Gosden, C.M., Blackwood, D.H.R., St. Clair, D.M., Muir, W.J.,
Brookes, A.J., and Porteous, D.J. (1995) Minor author
"A three megabase contiguous clone map on the long arm of chromosome 11
across a balanced translocation associated with schizophrenia"
Genomics, 28: 420-428
He, L., Mansfield, D.C., Brown, A.F., Green, D.K., St. Clair, D.M., Muir, W.J.,
Morris, S.W., Wright, A.F., and Blackwood, D.H.R. (1995) Minor author
"Automated linkage analysis in psychiatric disorders"
American Journal of Medical Genetics, (Neuropsychiatric Genetics) 60: 192-198
Petit, J., Bosseau, P., Evans, K., Gosden, C., Muir, W., St. Clair, D., Porteous,
D., and Arvelier, B. (1995) Minor author
Seeding of YAC's over regions 1 q41 -42,3 and 11 q14.3-q23 with microdissection
clones"
European Journal of Human Genetics, 3: 351-3561996Battersby, S., Ogilvie, A.D., Smith, C.A.D., Blackwood, D.H.R., Muir, W.J.,
Quinn, J., Fink, G., Goodwin, G.M., and Harmar, A.J. (1996) Minor author
"Structure of a variable number tandem repeat of the serotonin transporter gene
and association with affective disorder"
Psychiatric Genetics, 6: 177-181
Blackwood, D.H.R. Muir, W.J., Stevenson, A., Wentzel, J., Ad'hiah, A., Walker,
M.T., Papiha, S.S., St. Clair, D.M., and Roberts, D.F., (1996) Major author
"Reduced expression of HLA B35 in schizophrenia"
Psychiatric Genetics, 6: 51-59
Harmar A.J., Ogilvie, A.D., Battersby S., Smith, C.A.D., Blackwood, D.H.R, Muir,
W.J., Fink, G., and Goodwin, F.M. (1996) Minor author
"The serotonin transporter gene and affective disorder"
Cold Spring Harbor Symposia on Quantitative Biology, LXI: 791-795
He, L., Carothers, A., Blackwood, D.H.R., Teague, P., Maclean, A.W., Brown, J.,
Wright, A.W., Muir, W.J., Porteous, D.J., and St. Clair, D.M. (1996) Minor author
"Recombination patterns around the breakpoint of a balanced 1:11 autosomal
translocation associated with major mental illness"
Psychiatric Genetics, 6: 201-208
He, L., Morris, S., Lennon, A., St. Clair, D.M., Porteous, D.J., Wright, A.F., Muir,
W.J., and Blackwood, D.H.R. (1996) Major author
"A genome-wide search for linkage in a large bipolar family: comparison of
genotyping accuracy using di- and tetra-nucleotide repeat microsatellite markers"
Psychiatric Genetics, 6: 123-129
Schizophrenia Linkage Collaborative Group For Chromosomes 3, 6, and 8:
Levinson, D.F., Wildenauer, D.B., Schwab, S.G., Albus, M., Hallmayer, J., Lerer,
B., Maier, W., Blackwood, D., Muir, W., StClair, D., Morris, S., Moises, H.W.,
Yang, L., Kristbjarnarson, H., Helgason, T., Wiese, C., Collier, D.A., Holmans, P.,
Daniels, J., Rees, M., Asherson, P., Roberts, Q., Cardno, A., Arranz, M.J.,
Vallada, H., McGuffin, D., Owen, M.J., Pulver, A.E., Antonarakis, S.E., Babb, R.,
Blouin, J.L., Demarchi, N., Dombroski, B., Housman, D., Karayiorgou, M., Ott, J.,
Kasch, L., Kazazian, H., Lasseter, V.K., Loetscher, E., Luebbert, H., Nestadt, G.,
Ton, C., Wolyniec, P.S., Laurent, C., Dechaldee, M., Thibaut, F., Jay, M.,
Samolyk, D., Petit, M., Campion, D., Mallet, J., Straub, R.E., Maclean, C.J.,
Easter, S.M., Oneill, F.A., Walsh, D., Kendler, K.S., Gejman, P.V., Cao, Q.H.,
Gershon, E., Badner, J., Beshah, E., Zhang, J., Riley, B.P., Rajagopalan, S.,
Mogudicarter, M., Jenkins, T., Williamson, R., DeLisi, L.E., Garner, C., Kelly, M.,
Leduc, C., Cardon, L., Lichter, J., Harris, T., Loftus, J., Shields, G., Comasi, M.,
Vita, A., Smith, A., Dann, J., Joslyn, G., Gurling, H., Kalsi, G., Brynjolfsson, J.,
Curtis, D., Sigmundsson, T., Butler, R., Read, T., Murphy, P., Chen, A.C.H.,
Petursson, H., Byerley, B., Hoff, M., Holik, J., Coon, H., Nancarrow, D.J., Crowe,
R.R., Andreasen, N., Silverman, J.M., Mohs, R.C., Siever, L.J., Endicott, J.,
Sharpe, L., Walters, M.K., Lennon, D.P., Hayward, N.K., Sandkuijl, L.A., Mowry,
B.J., Aschauer, H.N., Meszaros, K., Lenzinger, E., Fuchs, K., Heiden, A.M.,
Kruglyak, L., Daly, M.J., and Matise, T.C. (1996) Minor author
"Additional support for schizophrenia linkage on chromosomes 6 and 8: a
multicenter study"
American Journal of Medical Genetics 67: 580-594
Schizophrenia Collaborative Linkage Group for Chromosome 22 (1996) - Gill, M.,
Vallada, H., Collier, D., Sham, P., Holmans, P., Murray, R., McGuffin, P., Nanko,
S., Owen, M., Lasseter, V.K., Pulver, A.E., Meyers, D., Nestadt, G., Antonarkis,
S., Housman, D, Childs, B., Straub, R., Su, Y., MacLean, C., Murphy, B., Wang,
S., Walsh, D., Kendler, K., Polymeropoulos, M., Coon, H., Byerley, W., Gershon,
E., Golden, L., Crow, T., DeLisi, L., Freedman, R., Reimherr, F., Wnder, P.,
Larent, C., Dumas, J-B., D'Amato, T., Jay, M., Martinez, M., Campion, D., Mallet,
J., Wildenauer, D., Flallmayer, J., Lerer, B., Maier, W., Schwab, S., Ebstein, R.,
Gurling, H, Curtis, D., Blackwood, D., Muir, W., St. Clair, D., Fie, L., Maguire, S.,
Moises, Ft., Yang, L., Wiese, C., Kristbjarnson, Ft., Levinson, D., and Mowry, B.
(1996) Minor author
"A combined analysis of D22S278 marker alleles in affected sib-pairs: support for
a susceptibility locus for schizophrenia at 22q12"
American Journal of Medical Genetics (Neuropsychiatric Genetics) 67: 40-451997Lindholm, E., Cavelier, L., Ffowell, M., Eriksson, I., Jalonen, P., Adolfsson, R.,
Blackwood, D.FI.R., Muir, W.J., Brookes, A.J., Gyllensten, U., and Jazin, E.E.
(1997) Minor author
"Mitochondrial sequence variants in patients with schizophrenia"
European Journal of Fluman Genetics, 5: 406-412
Mors, O., Ewald, FL, Blackwood, D., and Muir, W. (1997) Major author
"Cytogenetic abnormalities on chromosome 18 associated with bipolar affective
disorder or schizophrenia"
British Journal of Psychiatry, 170: 278-280
Wilson-Annan, J.C., Blackwood, D.FI.R., Muir, W., Millar, J.K., and Porteous, D.J.
(1997) Major author
"An allelic association study of two polymorphic markers in close proximity to a
balanced translocation breakpoint t(1 ;11) which co-segregates with mental
illness"
Psychiatric Genetics 7: 171-1741998Asherson, P., Mant, R., Williams, N., Cardno, A., Jones, L., Murphy, K., Collier,
D.A., Nanko, S., Craddock, N., Morris, S., Muir, W., Blackwood, D., McGuffin, P.,
and Owen, M.J. (1998) Minor author
"A study of chromosome 4p markers and dopamine D5 receptor gene in
schizophrenia and bipolar disorder"
Molecular Psychiatry, 3: 310-320
Doris, A.B., Wahle, K., MacDonald, A., Morris, S., Coffey, I., Muir, W., and
Blackwood, D. (1998) Major author
"Red cell membrane fatty acids, cytosolic phospholipase-A2 and schizophrenia"
Schizophrenia Research, 31: 185-196
Millar, J.K., Brown, J., Maule, J.C., Shibasaki, Y., Christie, S., Lawson, D.,
Anderson, S., Wilson-Annan, J.C., Devon, R.S., St. Clair, D.M., Blackwood,
D.H.R., Muir, W.J., and Porteous, D.J. (1998) Major author
"A long-range restriction map across 3 Mb of the chromosome 11 breakpoint of a
translocation linked to schizophrenia: Localisation of the breakpoint and the
search for neighbouring genes."
Psychiatric Genetics, 8: 175-182
Souery, D., Lipp, O., Serretti, A., Mahieu, B., Rivelli, S.K., Cavallini, C.,
Ackenheil, M., Adolfsson, R., Aschauer, H., Blackwood, D., Dam, H., Delcoigne,
B., Demartelaer, V., Dikeos, D., Fuchshuber, S., Heiden, M., Jablensky, A.,
Jakovljevic, M., Kessing, L., Lerer B., Macedo, A., Mellerup, T., Milanova, V.,
Muir, W., Nylander, P.O., Oruc, L., Papadimitriou, G.N., Pekkarinen, P.,
Peltonen, L., Pinto De Azevedo, M.H., Pull, C., Shapira, R., Smeraldi, E., Staner,
L., Stefanis, C., and Verga, M. (1998) Minor author
"European collaborative project on affective disorders: interactions between
genetic and psychosocial vulnerability factors" Minor author
Psychiatric Genetics, 8: 197-205
Williams, J., Spurlock, G., Holmans, P., Mant, R., Murphy, K., Jones, L., Cardno,
A., Asherson, P., Blackwood, D., Muir, W., Meszaros, K., Aschauer, H., Mallet,
J., Laurent, C., Pekkarinen, P., Seppala, J., Stefanis, C.N., Papadimitriou, G.N.,
Macciardi, F., Verga, M., Pato, C., Azevedo, H., Crocq, M-A., Gurling, H., Kalsi,
G., Curtis, D., McGuffin, P., and Owen, M.J. (1998) Minor author
"A meta-analysis and transmission disequilibrium study of association between
the dopamine D3 receptor gene and schizophrenia"
Molecular Psychiatry, 3: 141-149
Vallada, H., Curtis, D., Sham, P., Kunugi, H., Zhao, J.H., Murray, R., McGuffin,
P., Nanko, S., Owen, M., Gill, M., Collier, D.A., Antonarakis, S., Housman, D.,
Kazazian, H., Nestadt, G., Pulver, A.E., Straub, R.E., MacLean, C.J., Walsh, D.,
Kendler, K.S., DeLisi, L., Polymeropoulos, M., Coon, H., Byerley, W., Lofthouse,
R., Gershon, E., Goldin, L., Freedman, R., Laurent, C., Bodeau-Pean, S.,
d'Amato, T., Jay, M., Campion, D., Mallet, J., Wildenauer, D.B., Lerer, B., Albus,
M., Ackenheil, M., Ebstein, R.P., Hallmayer, J., Maier, W., Gurling, H., Curtis, D.,
Kalsi, G., Brynjolfsson, J., Sigmundson, T., Petursson, H., Blackwood D., Muir,
W., St Clair, D., He, L., Maguire, S., Moises, H.W., Hwu, H.G., Yang, L., Wiese,
C., Kristbjarnarson, H., Levinson, D.F., Mowry, B.J., Donis-Keller, H., Hayward,
N.K., Crowe, R.R., Silverman, J.M., Nancarrow, D.J., Read, C.M. (1998) Minor
author
"A transmission disequilibrium and linkage analysis of D22S278 marker alleles in
574 families: further support for a susceptibility locus for schizophrenia at 22q12"
Schizophrenia Research 32: 115-1211999Battersby, S., Ogilvie, A.D., Blackwood, D.H., Shen, S., Muqit, M.M., Muir, W.J.,
Teague P., Goodwin, G.M., and Harmar, A.J. (1999) Minor author
"Presence of multiple functional polyadenylation signals and a single nucleotide
polymorphism in the 3' untranslated region of the human serotonin transporter
gene"
Journal of Neurochemistry, 72: 1384-1388
Blackwood, D.H.R., Glabus, M.F., Dunan, J., O'Carroll, R.E., Muir, W.J., and
Ebmeier, K.P. (1999)
"Altered cerebral perfusion measured by SPET in relatives of schizophrenic
patients: correlations with memory and P300" Major author
British Journal of Psychiatry, 175: 357-366
Craddock, N., Lendon, C., Cichon, S., Culverhouse, R., Detera-Wadleigh, S.,
Devon, R., Faraone, S., Foroud, T., Gejman, P., Leonard, S., Mclnnis, M., Owen,
M.J., Riley, B., Armstrong, C., Barden, N., van Broeckhoven, C., Ewald, H.,
Folstein, S., Gerhard, D., Goldman, D., Gurling, H., Kelsoe, J., Levinson, D.,
Muir, W., Philippe, A., Pulver, A., Wildenauer, D. (1999) Minor author
"Chromosome Workshop: Chromosomes 11, 14, and 15"
American Journal of Medical Genetics; Neuropsychiatric Genetics 88:244-254
Furlong, R.A., Rubinsztein, J.S., Ho L, Walsh, C., Coleman, T.A., Muir, W.J.,
Paykel, E.S., Blackwood, D.H.R., and Rubinsztein, D.C. (1999) Minor author
"Analysis and meta-analysis of two polymorphisms within the tyrosine
hydroxylase gene in bipolar and unipolar affective disorders"
American Journal of Medical Genetics: Neuropsychiatric Genetics 88: 88-94
Hampson, R.M., Malloy, M.P., Mors, O., Ewald, H., Flannery, A.V., Morten, J.,
Porteous, D.J., Muir, W.J., and Blackwood, D.H.R. (1999) Major author
"Mapping studies on a pericentric inversion (18) (p11.31 q21.1) in a family with
both schizophrenia and learning disability"
Psychiatric Genetics, 9: 161-163
Souery, D., Lipp, O, Mahieu, B., Rivelli, S.K., Massat, I., Seretti, A., Cavallini, C.,
Ackenheil, M., Adolfsson, R., Aschauer, H., Blackwood, D., Dam, H., Dikeos, D.,
Fuchshuber, S., Heiden, M., Jakovljevic, M., Kaneva, R., Kessing, L., Lerer, B.,
Lonnqvist, J., Mellerup, T., Milanova, V., Muir, W., Nylander, P.O., Oruc, L.,
Papadimitriou, G.N., Pekkarinen, P., Peltonen, L., Pull, C., Raeymaekers, P.,
Shapira, B., Smeraldi, E., Staner, L., Stefanis, C., Verga, M., Verheyen, G.,
Macciardi, F., Van Broeckhoven, C., and Mendelwicz, J. (1999) Minor author
"Tyrosine hydroxylase polymorphism and phenotypic heterogeneity in bipolar
affective disorder: a multicenter association study"
American Journal of Medical Genetics (Neuropsychiatric Genetics), 88: 527-532
Visscher, P.M., Haley, C.S., Heath, S.C., Muir, W.J., and Blackwood, D.FI.R.
(1999) Major author
"Detecting QTLs for uni and bipolar disorder using a variance component
method"
Psychiatric Genetics, 9: 75-84.2000Serretti, A., Macciardi, F., Cusin, C., Lattuada, E., Souery, D., Lipp, O., Mahieu,
B., Van Broeckhoven, C., Blackwood, D., Muir, W„, Aschauer, H.N., Heiden,
A.M., Ackenheil, M., Fuchshuber, S., Raeymaekers, P., Verheyen, G., Kaneva,
R., Jablensky, A., Papadimitriou, G.N., Dikeos, D.G., Stefanis, C.N., Smeraldi, E.,
and Mendlewicz, J. (2000) Minor author
"Linkage of mood disorders with D2, D3 and TH genes: a multicenter study"
Journal of Affective Disorders 58: 51-612001Borglum, A.D., Hampson, M., Kjeldsen, T.E., Muir, W., Murray, V., Ewald, H.,
Mors, O., Blackwood, D., and Kruse, T.A. (2001) Minor author
"Dopa decarboxylase genotypes may influence age at onset in schizophrenia"
Molecular Psychiatry, 6: 712-717
Devon, R.S., Anderson, S., Teague, P.W., Muir, W.J., Murray, V., Pelosi A.J.,
Blackwood, D.H.R and Porteous, D.J. (2001a) Minor author
"The genomic organisation of the metabotropic glutamate receptor subtype 5
gene and its association with schizophrenia"
Molecular Psychiatry 6: 311-314
Devon, R.S., Anderson, S., Teague, P.W., Burgess, P., Kipari, T.M.J., Semple,
C.A.M., Millar, J.K., Muir, W.J., Murray, V., Pelosi, A.J., Blackwood, D.H.R., and
Porteous, D.J. (2001b) Minor author
"Identification of polymorphisms within disrupted in schizophrenia 1 and disrupted
in schizophrenia 2, and an investigation of their association with schizophrenia
and bipolar disorder"
Psychiatric Genetics, 11: 71-78
Evans, K.L., Le Hellard, S., Morris, S.W., Lawson, D., Whitton, C., Semple,
C.A.M., Fantes, J.A., Malloy, M.P., Maule, J.C., Humphray, S.J., Ross, M.T.,
Bentley, D.R., Muir, W.J., Blackwood, D.H.R., and Porteous, D.J. (2001) Major
author
"A 6Mb high-resolution BAC/PAC contig of human 4p15.3-16.1, a candidate
region for bipolar affective disorder"
Genomics 71: 315-323
Millar, J.K., Christie, S., Anderson, S., Lawson, D., Loh, D. H-W., Devon, R.S.,
Arveiler, B., Muir, W.J., Blackwood, D.H.R., and Porteous, D.J. (2001) Minor
author
"Genomic structure and localisation within a linkage hotspot of Disrupted in
Schizophrenia 1, a gene disrupted by a translocation segregating with
schizophrenia"
Molecular Psychiatry 6: 173-178
Muir, W.J., Thomson, M.L., McKeon P, Mynett-Johnson L, Evans, K.L., Porteous
DJ and Blackwood, D.H.R. (2001) Major author
"Markers close to the dopamine D5 receptor gene (DRD5) show significant
association with schizophrenia but not bipolar disorder."
American Journal of Medical Genetics 105:152-158
Lerer, B., Macciardi, F., Segman, R.H., Adolfsson, R., Blackwood, D., Blairy, S.,
Del Favero, J., Dikeos, D.G., Kaneva, R., Lilli, R., Massat, I., Milanova, V., Muir,
W., Noethen, M., Oruc, L., Petrova, T., Papadimitriou, G.N., Rietschel, M.,
Serretti, A., Souery, D., Van Gestel, S., Van Broeckhoven, C., and Menlewicz, J.
(2001) Minor author
"Variability of 5-FIT2C receptor cys23ser polymorphism among European
populations and vulnerability to affective disorder"
Molecular Psychiatry, 6: 579-585
Souery, D., Van Gestel, S., Massa
