5 research outputs found
Enzyme immobilization: an update
No full textCompared to free enzymes in solution, immobilized enzymes are more robust and more resistant to environmental changes. More importantly, the heterogeneity of the immo-bilized enzyme systems allows an easy recovery of both enzymes and products, multiple re-use of enzymes, continuous operation of enzymatic processes, rapid termination of reactions, and greater variety of bioreactor designs. This paper is a review of the recent literatures on enzyme immobilization by various techniques, the need for immobilization and different applications in industry, covering the last two decades. The most recent papers, patents, and reviews on immobilization strategies and application are reviewed
Purification and characterization of a novel thermostable luciferase from Benthosema pterotum
No full textInvestigating the effects of inelastic soil–foundation interface response on the seismic demand of soil–structure systems
No full textThe effect of inelastic response of the soil–foundation interface is explored on the seismic demand of structures attached on top of shallow foundations. An ensemble of 20 strong ground motions recorded on National Earthquake Hazards Reduction Program site class D was employed for analyzing soil–structure systems with the Winkler foundation model and an equivalent single-degree-of-freedom system as the superstructure. Results show that there are key parameters that control the amount of difference between the elastic and inelastic modeling of the soil at the soil–foundation interface. Depending on the structural aspect ratio, the elastic modeling leads to an overestimated result for the total lateral displacement demands. Also, more than 50% reduction in the superstructure demands is desired when nonlinear soil modeling is considered and foundation sliding is allowed. The benefits from the “shrinking-dominated rocking motion” can be acquired with inelastic soil material that limits the transferred inertial force into the superstructure.The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
Lipoid congenital adrenal hyperplasia with cholestatic jaundice
No full textBACKGROUND AND OBJECTIVE: Lipoid congenital adrenal hyperplasia (LCAH) is the most severe form of adrenal hyperplasia and mutations in the StAR gene are the most common cause of the disease. Adrenal insufficiency and cholestasis are reported in few patients. The aim of this study was to report the results of treatment of two sisters with lipoid CAH and cholestatic jaundice. CASE REPORTS: Here, we present two sisters at the age of 30 and 60 days with conjugated hyperbilirubinemia and elevated liver enzymes and adrenal insufficiency. They had a 46,XY karyotype with external female genitalia without uterus and ovaries. LCAH was detected through electrolyte abnormalities, increased ACTH, decreased levels of cortisol and sex hormones and was confirmed by determination of exome sequencing and Sanger sequencing. In these patients, a homozygous mutation (c.653C>T) in exon 6 of STAR gene was identified. The patients were treated with 10 mg of hydrocortisone IV every 8 hours for 3 days; oral hydrocortisone was then administered at a dose of 2.5 mg every 8 hours and 0.2 mg fludrocortisone daily. One month after the therapy, levels of bilirubin and liver enzymes of these patients became normal. The first patient died 7 months after her mother stopped giving the drugs to the child. The other patient is now 9 years old. She is in good clinical condition as her treatment goes on. CONCLUSION: Considering the reported cases, adrenal lipoid hyperplasia should be considered as a rare cause of cholestasis with adrenal insufficiency in patients. © 2021, Babol University of Medical Sciences. All rights reserved.
Author keywords
Adrenal Insufficiency; Karyotype; Lipoid CAH; Neonatal Cholestasi
Energy performance of a university building for different air conditioning (AC) technologies: a case study
No full textThe study uses four AC technologies to assess the energy performance—this is a case study of an educational building in Barranquilla, Colombia. The building currently has split AC technology high-energy consumers. Therefore, it was necessary to assess a replacement with more efficient technology. Because of the non-seasonal climate in the building location, one month of monitoring of energy consumption was the reference for developing an energy model for the building using EnergyPlus and DesignBuilder software. The model was applied to forecast the building energy performance of our more efficient AC technologies available in the Colombian market, and valuable according to building specifications (Split, VRF, VAV, and Chiller). Results show a reduction in energy consumption of approximately 30% with the technology change and 15% savings in life cycle costs (LCCs), even though the building is already considered to have a low energy consumption according to national regulations. The findings of this study underscore the potential for widespread applicability across all types of buildings, regardless of their energy consumption profile, be it low, medium, or high. This extensive applicability not only highlights the adaptability and versatility of the technology but also underscores its significance in achieving substantial energy savings and cost reductions across the entire building industry, contributing to a more sustainable and economically efficient future
