1,976 research outputs found
Three-Dimensional Reconstruction of the Giant Mimivirus Particle with an X-Ray Free-Electron Laser
No full textCitation: Ekeberg, T., Svenda, M., Abergel, C., Maia, F., Seltzer, V., Claverie, J. M., . . . Hajdu, J. (2015). Three-Dimensional Reconstruction of the Giant Mimivirus Particle with an X-Ray Free-Electron Laser. Physical Review Letters, 114(9), 6. doi:10.1103/PhysRevLett.114.098102We present a proof-of-concept three-dimensional reconstruction of the giant mimivirus particle from experimentally measured diffraction patterns from an x-ray free-electron laser. Three-dimensional imaging requires the assembly of many two-dimensional patterns into an internally consistent Fourier volume. Since each particle is randomly oriented when exposed to the x-ray pulse, relative orientations have to be retrieved from the diffraction data alone. We achieve this with a modified version of the expand, maximize and compress algorithm and validate our result using new methods.Additional Authors: Andersson, I.;Loh, N. D.;Martin, A. V.;Chapman, H.;Bostedt, C.;Bozek, J. D.;Ferguson, K. R.;Krzywinski, J.;Epp, S. W.;Rolles, D.;Rudenko, A.;Hartmann, R.;Kimmel, N.;Hajdu, J
Imaging single cells in a beam of live cyanobacteria with an X-ray laser
No full textCitation: van der Schot, G., Svenda, M., Maia, F., Hantke, M., DePonte, D. P., Seibert, M. M., . . . Ekeberg, T. (2015). Imaging single cells in a beam of live cyanobacteria with an X-ray laser. Nature Communications, 6, 9. doi:10.1038/ncomms6704There exists a conspicuous gap of knowledge about the organization of life at mesoscopic levels. Ultra-fast coherent diffractive imaging with X-ray free-electron lasers can probe structures at the relevant length scales and may reach sub-nanometer resolution on micron-sized living cells. Here we show that we can introduce a beam of aerosolised cyanobacteria into the focus of the Linac Coherent Light Source and record diffraction patterns from individual living cells at very low noise levels and at high hit ratios. We obtain two-dimensional projection images directly from the diffraction patterns, and present the results as synthetic X-ray Nomarski images calculated from the complex-valued reconstructions. We further demonstrate that it is possible to record diffraction data to nanometer resolution on live cells with X-ray lasers. Extension to sub-nanometer resolution is within reach, although improvements in pulse parameters and X-ray area detectors will be necessary to unlock this potential.Additional Authors: Almeida, N. F.;Odic, D.;Hasse, D.;Carlsson, G. H.;Larsson, D. S. D.;Barty, A.;Martin, A. V.;Schorb, S.;Bostedt, C.;Bozek, J. D.;Rolles, D.;Rudenko, A.;Epp, S.;Foucar, L.;Rudek, B.;Hartmann, R.;Kimmel, N.;Holl, P.;Englert, L.;Loh, N. T. D.;Chapman, H. N.;Andersson, I.;Hajdu, J.;Ekeberg, T
Ochrana práv původního obyvatelstva v současném mezinárodním právu
No full textSlavomír Rudenko: Ochrana práv pôvodného obyvateľstva v súčasnom medzinárodnom práve (dizertačná práca). Právnická fakulta UK, Praha, 2012 Školiteľ: prof. JUDr. Pavel Šturma, DrSc. Kľúčové slová: pôvodné obyvateľstvo, menšiny, kolonializmus, autochtónny, medzinárodné obyčajové právo, ochrana ľudských práv, kolektívne práva, právo na sebaurčenie, zákaz diskriminácie, kultúrna integrita, práva k pôde a prírodným zdrojom, právo na zastúpenie, slobodný predchádzajúci informovaný súhlas, monitorovacie mechanizmy, medzinárodné procesné postupy podávania sťažností, uplatňovanie záväzkov, vnútroštátna jurisdikcia, multikulturalizmus Dizertačná práca adresuje pohľad na problematiku postavenia pôvodného obyvateľstva tak, ako je reflektovaná z hľadiska súčasnej úpravy medzinárodného práva. V zmysle tohto svojho zamerania si kladie za cieľ prezentovať charakteristiku príslušného medzinárodného normatívneho systému, analyzovať jeho univerzálne i regionálne nástroje a priblížiť skúmanú problematiku i z pohľadu aktuálnych diskusií, prebiehajúcich vo vede medzinárodného práva. Je zámerom autora prezentovať na podklade historických procesov degradovania, potláčania ľudských práv a diskriminácie pôvodných obyvateľov v kontexte súčasných štátov zvýšenú pozornosť medzinárodného spoločenstva potrebám a ochrane...Slavomir Rudenko: Protection of Indigenous Peoples' Rights under Contemporary International Law (Dissertation Thesis). Law Faculty of Charles University, Prague, 2012 Supervisor: prof. JUDr. Pavel Šturma, DrSc. Key words: indigenous peoples; minorities; colonialism; native; international customary law; protection of human rights; collective rights; right to self-determination; non-discrimination; cultural integrity; right to lands and natural resources; right to participation; free, prior and informed consent; monitoring mechanisms, international complaint procedures; implementation of obligations; national jurisdiction; pluriculturalism The dissertation thesis addresses the issues of the status of indigenous peoples as reflected by contemporary international law. In this scope, it aspires to present the characteristic features of the respective international order, to draw an analysis of both its universal and regional instruments and identify the subject matter in the light of the ongoing academic debate and the most current practice of international law. Against the background of historical processes of degradation, suppression, denial of human rights and discrimination of indigenous peoples it is the author's aim to highlight the rising interest of the international community, taking shape over...Department of Public International LawKatedra mezinárodního právaFaculty of LawPrávnická fakult
Geophysical noise in the virgo gravitational antenna
No full textThe possibility of obtaining geophysical information from the system for controlling the position of the mirrors of the VIRGO laser-interferometric gravitational antenna and from angular perturbations of the vertical mirror lines is examined. Results from a study of tidal horizontal deformations are analyzed. © 2009 Springer Science+Business Media, Inc
Reception frequency bandwidth of a gravitational resonant detector with optical readout
No full textA gravitational resonant bar detector with a large scale Fabry-Perot (FP) cavity as an optical readout and a mechanical displacement transformer is considered. We calculate, in a fully analytical way, the final receiver bandwidth in which the potential sensitivity, limited only by the bar thermal noise, is maintained despite the additional thermal noise of the transformer and the additive noise of the optical readout. We also discuss an application to the OGRAN project, where the bar is instrumented with a 2 m long FP cavity
1-Substituted Cyclopentylamines from Nitriles and Tetramethylenebismagnesium Dibromide in the Presence of Ti(OiPr)(4)
No full textVarious 1-substituted cyclopentylamines (25 examples, 10-89% yield) have been prepared according to a one-pot procedure by the addition of tetramethylenebismagnesium di-bromide in the presence of Ti(OiPr)(4) to aliphatic, aromatic and heteroaromatic nitriles, respectively.KAdemCustomChem GmbH; Land Niedersachse
Photo-induced plasma confinement in ultrashort laser-excited nanostructures
No full textInternational audienceIntense ultrashort lasers modify transient optical properties of transparent materials, converting them into cold plasma non-equilibrium state of matter. This electron-hole plasma can be confined to subwavelength nanoscale dimensions by tightly focused laser beams but remains challenging to control due to complexity of ultrashort pulse propagation in nonlinear medium and is mainly associated with laser material damage in laser processing [1]. Subwavelength nanostructures and their periodic planar arrangements (metasurfaces) enable not only plasma confinement on record nanoscales by ultrashort laser excitation [2] but also better control over the nonlinear optical response while resisting to material damage [3], which is promising for new-generation optical devices for light manipulation and modulation.Modeling of the involved physical processes remains challenging, as it requires coupling non-paraxial full-vector light propagation in nonlinear medium with a comprehensive model for electronic excitation and material ionization at high intensities. Laser interaction with subwavelength nanostructures is discussed in the frame of 3D plasma fluid model coupled with nonlinear Maxwell propagation solver. Simulation results elucidate the spatio-temporal aspects of the electron-hole plasmas and their influence on ultrashort pulse propagation and harmonic generation.Apart from numerous applications relying on transient optical properties, plasma nanoconfinement in nanostructured transparent materials opens new opportunities for controlling thermal gradients, melt flow, and ablation at the nanoscale, with the ultimate objective to develop new strategies for nanofabrication and adjustment of metasurfaces.Références[1] A. Rudenko, J. V. Moloney, and P. Polynkin, Phys. Rev. Appl., Vol. 20, 064035 (2023)[2] A. Rudenko, K. Ladutenko, S. Makarov, and T. E. Itina, Adv. Opt. Mater., Vol. 7, 12306 (2018)[3] A. Rudenko, A. Han, and J. V. Moloney, Adv. Opt. Mater., Vol. 11, 2, 2201654 (2023
Statistical analysis of the Explorer gravitational detector noise in time intervals corresponding to BATSE gamma ray events
No full textThe features of pathogenetically directed therapy for chronic pelvic pain syndrome in experimental condition
No full textRudenko A. V., Kostyev F. I. The features of pathogenetically directed therapy for chronic pelvic pain syndrome in experimental condition. Journal of Education, Health and Sport. 2015;5(8):55-63. ISSN 2391-8306. DOI 10.5281/zenodo.22824
http://dx.doi.org/10.5281/zenodo.22824
https://pbn.nauka.gov.pl/works/601988
POL-index https://pbn.nauka.gov.pl/polindex/browse/article/article-1b41c63c-c463-4013-bd18-684b35de96a0
http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%288%29%3A55-63
Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive
Deklaracja.
Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.
Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.
The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).
© The Author (s) 2015;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 20.06.2015. Revised 15.07.2015. Accepted: 25.07.2015.
UDC: 617.581-009.7-092.9-0.85+618.13-009.7-0.92.9-0.85
The features of pathogenetically directed therapy for chronic pelvic pain syndrome in experimental condition
A. V. Rudenko, F. I. Kostyev
Odessa National Medical University, Odessa
Keywords: pudendopathy, experiment, model, pathogenesis, muscle relaxants, adrenergic agonists, neurotrophic drugs.
Abstract
Experimental methods for investigation were performed on 120 four-month age white mongrel male rats, by the sacral plexus damage in animals through the ligating the largest nerve of the plexus - sciatic nerve, which can be considered as a predictor of pudendopathy and adequate clinical experimental modeling of the prototype method. The experimental animals after 1 month. of modeling were taken medications with muscle relaxant action of the central and peripheral activity and also neurotrophic effect. Comparative assessment of medicines was performed after 2.5 months. by morphological investigation of the pelvic floor and bladder, as well as biochemical analysis of blood, homogenates of the pelvic floor muscles and bladder, with assessment of the α2-macroglobulin, creatine kinase and lactate activity. The results showed that the pudendal nerve neuropathy in the experiment is accompanied by severe changes in the structure of the tissue of the bladder, pelvic floor muscles, nerve structures of the pelvis, as well as hypoxia, proteolysis and tissue destruction. The injection of drugs to experimental animals with reproduced pudendopathy revealed the different efficacy in restoring the structure of the detrusor muscle and the pelvic floor depending on effect of the drug
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