100 research outputs found
Vasa vasorum lumen narrowing in brain vascular hyalinosis in systemic hypertension patients who died of ischemic stroke
No full textIschemic stroke is a major cause of death among patients with systemic hypertension. The narrowing of the lumen of the brain vasculature contributes to the increased incidence of stroke. While hyalinosis represents the major pathological lesions contributing to vascular lumen narrowing and stroke, the pathogenic mechanism of brain vascular hyalinosis has not been well characterized. Thus, the present study examined the postmortem brain vasculature of human patients who died of ischemic stroke due to systemic hypertension. Hematoxylin and eosin staining and immunohistochemistry showed the occurrence of brain vascular hyalinosis with infiltrated plasma proteins along with the narrowing of the vasa vasorum and oxidative stress. Transmission electron microscopy revealed endothelial cell bulge protrusion into the vasa vasorum lumen and the occurrence of endocytosis in the vasa vasorum endothelium. The treatment of cultured microvascular endothelial cells with adrenaline also promoted the formation of the bulge as well as endocytic vesicles. The siRNA knockdown of sortin nexin-9 (a mediator of clathrin-mediated endocytosis) inhibited adrenaline-induced endothelial cell bulge formation. Adrenaline promoted protein-protein interactions between sortin nexin-9 and neural Wiskott–Aldrich syndrome protein (a regulator of actin polymerization). Spontaneously hypertensive stroke-prone rats also exhibited lesions indicative of brain vascular hyalinosis, the endothelial cell protrusion into the lumen of the vasa vasorum, and endocytosis in vasa vasorum endothelial cells. We propose that endocytosis-dependent endothelial cell bulge protrusion narrows the vasa vasorum, resulting in ischemic oxidative damage to cerebral vessels, the formation of hyalinosis, the occurrence of ischemic stroke, and death in systemic hypertension patients
Outlooks of therapy for genital herpes
No full textHerpesvirus infections are widespread in humans. Approximately 6–10% of adults suffer from genital herpes and 10–20% of them have recurrent disease. Herpesvirus infections (including asymptomatic and silent forms) were found to have a negative effect on human reproductive health. Herpes simplex virus can infect germ cells, impair spermatogenesis, and play a certain pathogenetic role in the development of infertility. Herpes is a serious medical and social problem. Patients with recurrent herpes often have imbalanced immune responses involving interferons and other cytokines, as well as inhibition of cellular and phagocytic reactions of the organism. Meglumine acridone acetate, an interferon inducer, demonstrated high clinical and immunological efficacy in the treatment and prevention of recurrent herpes. The drug can be combined with other medications and is well tolerated by patients
Testing of tomato hybrids of the breeding of the company "Gavrish" in JSC "Teplichnoye" of the Tambov region
No full textRelevance Currently, the requirements for modern tomato hybrids are increasing both from consumers and from producers. Modern tomato hybrids in extended circulation should yield at least 60 kg / m2, be distinguished by high quality of fruits, early ripeness, possess manufacturability, resistance to major diseases. Along with the traditional form of fruits, hybrids with original shape, color, taste and aroma are interesting for manufacturers. Methods The aim of the research was the variety study of indeterminant F1 hybrids of tomato breeding of the company "Gavrish" in JSC "Teplichnoye" of the Tambov region. Studies were conducted in 2017-2018 in the extended and summer-autumn turnover in the conditions of JSC "Teplichnoye" of the Tambov region in accordance with generally accepted recommendations for research with vegetable crops in greenhouses. The objects of the study in extended circulation were tomato hybrids: F1 Bao Bab, F1 Baloven, the F1 Torero hybrid was taken as a control. In the summerautumn turnover, a study was made of the rose hybrid – F1 Panthera; the Rosario F1 hybrid was used as a control; a hybrid with a plum-shaped fruit – F1 Armata, control – a hybrid F1 Lezghinka. Results According to the results of the study of tomato hybrids, the selection of the Gavrish company at the enterprise made the decision to grow it in extended circulation and increase the area under F1 Baloven, in the summer-autumn turnover under the F1 Panthera hybrid
Efficiency of the use for doubled haploids in onion breeding (<i>Allium cepa</i> L.)
No full textRelevance. In onion breeding, quickly obtain aligned material is an urgent target for create parent forms of heterosis hybrids. Using classical methods with helping of backcrosses, this is achieved in 10-12 years. Using the technology of doubled haploids, it is possible to reduce these terms several times, and also to avoid the manifestation of inbred depression when obtaining lines by self-pollination. At the same time, the most effective in the production of haploids is the use of whole flower buds as an explant, unlike ovules and ovaries, the production of which is more time-consuming and labor-intensive.Methods. The doubled onion haploids were obtained by the method of ovule culture on the basis of the biotechnology laboratory of the Gavrish Breeding Center using the technology that based on the methodological recommendations of Monakhos S.G. et al., 2014. DH–onion plants with a developed root system and leaf apparatus were planted in the open ground and grown according to the technology generally accepted for the zone at the sites of the Gavrish breeding center, Krymsk, Krasnodar Territory. The obtained commercial bulbs were evaluated according to the RTG/46/2 method.Results. It was obtain doubled haploids, which were tested for ploidness by flow cytometry. 40 digaploid onion plants have been created. As a result of further development after transplantation into the open ground, storage, springization and selection, 3 uterine bulbs were obtained for further reproduction and inclusion in the breeding process
Společenské postavení osob s mentálním postižením v románu a povídce Daniela Keyese Flowers for Algernon
No full textTato práce si bere za cíl prozkoumat sociální postavení lidí s duševními poruchami v povídce a následně vydaném románu Daniela Keyese Růže pro Algernon (1959, 1966). Zmíněné téma je stále aktuální, neboť i teď si moderní společnost není zcela jista, jak by měla přistupovat k lidem s duševní poruchou, a umožnit jim tak stabilní sociální postavení. Teoretická část se zabývá dějinami duševních poruch a jejich klasifikací, a nechybí v ní ani příklady dalších literárních děl, v nichž se objevuje podobné téma. Hlavní část práce je zaměřena na zkoumání textu samotného románu a pro lepší pochopení dané problematiky se zde také analyzuje struktura, lexika, gramatika a syntax románu. Výsledky výzkumu této práce jsou uvedeny v závěru.The aim of this thesis is investigation of social standing of people with mental disorders in society using the example of Daniel Keyes's novel and short story Flowers for Algernon (1966, 1959). This subject matter is important to the modern society owing to the existence of people with the mental disorder who are not stable in their social position, as society is not sure how to treat this problem. The theoretical part deals with history of mental disorder, its classification and other examples of literary works on the corresponding subjects. The main body is focused on exploration of the text of the novel itself. In this part also is discussed using of composition, structure, lexis, grammar and syntax to provide the better understanding of the subject The results of research, provided in this thesis are described in the conclusion.Katedra anglického jazyka a literaturyPedagogická fakultaFaculty of Educatio
Дослідження впровадження етичного кодексу фармацевтичних працівників України у практичну діяльність
No full textThe important condition for solving problems of unethical behavior of the subjects of the pharmaceutical market is introduction the Ethics Code of Pharmacists of Ukraine into the practical activity. The article presents the results of a questionnaire survey of employees in the pharmaceutical sector of health care in order to identify the current trends related to introduction problems and mechanism of functioning of the Code. The analysis of normative legal acts that regulate implementation of the Code has been determined the aspects leading to the inefficient functioning of the Ethics Code of Pharmacists of Ukraine. Based on the research findings the main problems of introduction and functioning of the Code have been found, and the priority steps for introduction of the Ethics Code of Pharmacists of Ukraine into the practical activity have been identified.Важным условием решения проблем неэтичного поведения субъектов фармацевтического рынка является внедрение в практическую деятельность Этического кодекса фармацевтических работников Украины. В статье представлены результаты анкетного опроса работников фармацевтического сектора отрасли здравоохранения с целью выявления современных тенденций, касающихся проблем внедрения и механизма функционирования Этического коде са. В ходе анализа нормативно-правовых актов, регулирующих имплементацию кодекса, установлены аспекты, которые приводят к его неэффективному функционированию. По результатам исследований выявлены основные проблемы внедрения и функционирования кодекса, а также определены первоочередные шаги для его внедрения в практическую деятельность.Важливою умовою вирішення проблем неетичної поведінки суб’єктів фармацевтичного ринку є введення у практичну діяльність Етичного кодексу фармацевтичних працівників України.У статі наведено результати анкетного опитування працівників фармацевтичного секторагалузі охорони здоров’я з метою з’ясування сучасних тенденцій щодо проблем упровадження та механізму функціонування етичного кодексу. У ході аналізу нормативно-правових актів, що регулюють імплементацію кодексу, встановлено аспекти, які призводять до його неефективногофункціонування. За результатами дослідження встановлено основні проблеми впровадження та функціонування кодексу, а також визначено першочергові кроки в його упровадженні у практичну діяльність
Аналіз основних факторів, що обумовлюють виникнення моббінгу у фармацевтичних організаціях
No full textThe results of the sociological study on the occurrence of mobbing in the pharmaceutical companies and the factors that cause it are presented. The foreign experience of the legal regulation for protecting the rights of a worker to maintain his honor and dignity at work has been analyzed. For the purpose of preventive measures in order to avoid mobbing in organizations of the pharmaceutical branch a set of strategic and tactical actions has developed and defined to prevent mobbing manifestations and manage them in a pharmaceutical company.Приведены результаты социологического исследования по вопросу возникновения в фармацевтических организациях моббинга и определены факторы, которые его обусловливают.Проанализирован зарубежный опыт правового регулирования защиты права работника на сохранение его чести и достоинства во время трудовой деятельности. С целью превентивных мер по недопущению моббинга в организациях фармацевтического профиля разработана и определена совокупность стратегических и тактических действий, направленных на предотвращение моббинг-проявлений и противодействия им в фармацевтической организации.Наведено результати соціологічного дослідження з питання виникнення у фармацевтичних організаціях моббінгу та визначено фактори, що його обумовлюють. Проаналізовано зарубіжний досвід правового регулювання захисту права на гідність працівника під час трудової діяльності. З метою превентивних заходів із недопущення моббінгу в організаціях фармацевтичного профілю розроблено та визначено сукупність стратегічних і тактичних дій, спрямованих на запобігання моббінг-проявів і протидії їм у фармацевтичній організації
Strategy of energy raw material use
No full textThe article deals with the economic
study to determine the efficiency of
processing of agricultural products for export
is the biodiesel. The strategy of production and
export of biodiesel is a promising direction
New, promising, domestic hybrids smooth-fruited cucumber for light culture
No full textRelevance. Innovations in modern greenhouse complexes necessitate the creation of new technological cucumber hybrids for them, an important component of which is their comprehensive assessment in production conditions.Materials and methods. In 2023, experiments were conducted in the Krymsk (Krasnodar Territory) SC “Gavrish” with 9 new parthenocarpic hybrids of cucumber F1 smooth type in 2 repetitions of 10 plants each. Hybrids were grown in a winter greenhouse under light culture conditions in winter-spring and summer-autumn rotations. The technology of growing the crop is maintained in accordance with the requirements adopted in the V light zone. The assessment of economically valuable features was carried out according to generally accepted methods.Results. The early and total yields, marketability of the grown hybrids in two crop rotations, the degree of their resistance to real powdery mildew and adaptability of cultivation in crop rotations have been established. A comparative assessment of the potential of new hybrids with the generally accepted F1 analogue of Meva in the region has been carried out.Conclusions. The new parthenocarpic smooth-fruited cucumber hybrids of GC “Gavrish” F1 Metreng, Model 4560/19, Model 166/20 can act as an import substitution
The effect of structural flaws on the properties of the sapphire shell of a discharge radiation source
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