620 research outputs found
Portrait of Martha Strudwick Young
No full textThis is a circa 1880 portrait of author and poet, Martha Strudwick Young
Braidwood [music] /
No full textFor voice and piano.; Also available online http://nla.gov.au/nla.mus-an6492516; MUS: N, Snell.; Library's N copy inscribed and signed by the composer
Orthopaedic manifestations and management of Spondyloepimetaphyseal dysplasia Strudwick type
No full textSpondyloepimetaphyseal dysplasia (SEMD) Strudwick type is a rare autosomal dominant condition arising from defects in COL2A1 the genes responsible for the biosynthesis of procollagen type II. The orthopaedic manifestations of patients can be hypoplastic odontoid peg with atlantoaxial instability, severe kyphosis or lordosis of dorsal and lumbar spines, hip subluxation, coxa vara and early severe hip osteoarthritis, and malalignment of lower limbs like genu valgum or club foot. We report a mother and daughter with SEMD Strudwick Type and describe their orthopaedic problems, surgical management and clinical outcome after 30 years and 7 years of follow-up respectively.Spondyloepimetaphyseal dysplasia (SEMD) Strudwick type is a rare autosomal dominant condition arising from defects in COL2A1 the genes responsible for the biosynthesis of procollagen type II. The orthopaedic manifestations of patients can be hypoplastic odontoid peg with atlantoaxial instability, severe kyphosis or lordosis of dorsal and lumbar spines, hip subluxation, coxa vara and early severe hip osteoarthritis, and malalignment of lower limbs like genu valgum or club foot. We report a mother and daughter with SEMD Strudwick Type and describe their orthopaedic problems, surgical management and clinical outcome after 30 years and 7 years of follow-up respectively
Collagen loss and impaired wound healing is associated with c-Myb deficiency
No full textData source: Supporting information, http://onlinelibrary.wiley.com.access.library.unisa.edu.au/doi/10.1002/path.2113/abstract#footer-support-infoCollagen type I serves as an abundant structural and signalling component of skin. It is also an established target gene of the transcription factor, c-Myb. When c-myb-/- embryos were examined it was observed that their skin was markedly thinner than normal. Importantly, immunohistochemical investigation showed complete absence of collagen type I. Although these homozygous knock-out embryos fail to develop beyond day 15, fibroblasts established from these embryos (mouse embryonic fibroblasts [MEFs]) show defective proliferative responses. Furthermore, in vitro scratch wound assays demonstrated that these c-myb-/- MEFs also exhibit slower closure than their wild-type counterparts. Embryonic lethality has meant that examination of the role of c-Myb in adult mouse skin has not been reported to date. However, in view of the abundance of collagen type I in normal skin, its role in skin integrity and the in vitro data showing proliferative and migration defects in c-myb-/- MEFs, we investigated the consequences of heterozygous c-myb loss in adult mice on the complex process of skin repair in response to injury. Our studies clearly demonstrate that heterozygous c-myb deficiency has a functional effect on wound repair, collagen type I levels and, in response to wounding, transforming growth factor-β1 (an important collagen stimulating factor) induction expression is aberrantly high. Manipulation of c-Myb may therefore provide new therapeutic opportunities for improving wound repair while uncontrolled expression may underpin some fibrotic disorders.Z Kopecki, MM Luchetti, DH Adams, X Strudwick, T Mantamadiotis, A Stoppacciaro, A Gabrielli, RG Ramsay, AJ Cowi
The Value and Values of an Enterprise Culture
No full textRichard Strudwick, enterprise education specialist, has worked on various projects in training, youth support, development and facilitation in the UK, Australia and further afield. Through his work he has developed a real understanding of the needs of young people and the enormous benefits associated with understanding enterprise, investigating self-employment and cultivating an enterprising attitude. In this webinar Richard shares his experience with us.
Entropy network fusion
No full textThanks to the continual development of technology, a massive amount of data is now being produced on a daily basis. Because of this, new methods for analysis are needed, particularly ones that can analyse multiple datasets on the same set of objects. This is especially relevant in systems biology, where different datasets probe different aspects of the same underlying system. A popular and widely used method to analyse datasets is to transform the data into networks. Networks help visualise and quantify connections between samples, revealing structure and information that may not be visible at first, hence the popularity of their use, particularly in the analysis of biological systems. Entropy Network Fusion (ENF) is a new methodology for fusing, or combining, together multiple networks on the same set of objects (nodes) into one single output network. Itworks by finding a solution (network) whose clustering structure is as close as possible to the clustering structure of all the given input networks, using information-theoretic entropy as a guiding principle. ENF is designed with a level of generality, such that it is not restricted to any specific type of data, giving it a wide range of applications. We tested our methodology on five cancer sets and compared the performance to Similarity Network Fusion, a state-of-the-art network fusion algorithm. Whilst SNF may be a faster method, the output from ENF is significantly better in terms of performance. We then further developed an approximate version of our algorithm, approximate Entropy Network Fusion (aENF), which is significantly faster computationally for larger networks, further increasing its range of application
A Label for Opening of the Mouth Implements from the Burial of Senneferi (TT99) and Remarks on the Ritual
No full textIn 2009, Nigel Strudwick published a paper drawing attention to a number of objects found in TT99 which seem to have been used in the Opening of the Mouth ritual. In 2015 an hieratic label from the same burial was identified as possibly belonging to a bag or box in which these items were kept. This paper presents a full edition of the label, and offers further comments on the context where the objects were found, and also indicates lines of research for further study of the Opening of the Mouth ritual.In 2009, Nigel Strudwick published a paper drawing attention to a number of objects found in TT99 which seem to have been used in the Opening of the Mouth ritual. In 2015 an hieratic label from the same burial was identified as possibly belonging to a bag or box in which these items were kept. This paper presents a full edition of the label, and offers further comments on the context where the objects were found, and also indicates lines of research for further study of the Opening of the Mouth ritual
A Label for Opening of the Mouth Implements from the Burial of Senneferi (TT99) and Remarks on the Ritual
No full textIn 2009, Nigel Strudwick published a paper drawing attention to a number of objects found in TT99 which seem to have been used in the Opening of the Mouth ritual. In 2015 an hieratic label from the same burial was identified as possibly belonging to a bag or box in which these items were kept. This paper presents a full edition of the label, and offers further comments on the context where the objects were found, and also indicates lines of research for further study of the Opening of the Mouth ritual
From Farey Fractions to the Klein Quartic and beyond
No full textIn his 1878/79 paper "Ueber die transformation siebenter ordnung der elliptischen functionen", Klein produced his famous 14-sided polygon representing the Klein quartic, his Riemann surface of genus 3 which has PSL(2,7) as its automorphism group. The construction and method of side pairings are fairly complicated. By considering the Farey map modulo 7 we show how to obtain a fundamental polygon for Klein's surface using arithmetic. Now the side pairings are immediate and essentially the same as in Klein's paper. We also extend this idea from 7 to 11 as Klein attempted to do in his follow up paper "Ueber die transformation elfter ordnung der elliptischen functionen", in 1879
L'Usage de la 3D en Archéologie
No full textInternational audienceThe use of 3D medeling in archaeology has developed front the straightforwad production of images for illustrative purposes into becoming an effective tool to aid scientific archaeological research Virtual Reality allows not only the restoration of ancient structures which have now disappeared but also permits the testing of new hypotheses as ti how these structures worked. A particular use wuthin Egyptology has been the non-invasive studies of mummies with this new technology. However, in view of the importance of architectural remains along the Nile valley, there can be little doubt that the most significant potential lies in the virtual restoration of those structures. Although 3D images allow the public to understand better these processes, we should never lose sight of the fact that their production was driven by underbying scientific goals. A 3D technological ^platform specifically for work with our architectural heritage has been created in Bordeaux, it is especially adapted for 3D scanning, modelling and maintaining the persistence of 3D digital data
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